DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3823 and TTPA

DIOPT Version :9

Sequence 1:	NP_572313.1	Gene:	CG3823 / 31573	FlyBaseID:	FBgn0029863	Length:	295	Species:	Drosophila melanogaster
Sequence 2:	NP_000361.1	Gene:	TTPA / 7274	HGNCID:	12404	Length:	278	Species:	Homo sapiens

Alignment Length:	241	Identity:	64/241 - (26%)
Similarity:	108/241 - (44%)	Gaps:	18/241 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 PQLPQNISRLLLRRFLHTTRGDLSAAQRLLELNYGLRNKHAHIFIDRDP------LDASSQQLLQ 86
            |..|..::...|.|||.....||..|.|||:..|..|.:...|..|..|      |.|....:|:
Human    41 PLAPLPLTDSFLLRFLRARDFDLDLAWRLLKNYYKWRAECPEISADLHPRSIIGLLKAGYHGVLR 105

  Fly    87 VADLVPLPGLTPENNKLLFYRLIDFDADKFNFTAAIKVFFMVADCRFATENEERLSDGEIPVFDM 151
            ..|        |..:|:|.||:..:|...|......:|..:.::  ...:..|...:|...:||:
Human   106 SRD--------PTGSKVLIYRIAHWDPKVFTAYDVFRVSLITSE--LIVQEVETQRNGIKAIFDL 160

  Fly   152 AGYTLRHLTKTALGALRVYMKFVQEAHPVRLKEIHVLNCPSYVDKVMAVVKPFIKGEVFKLIHFH 216
            .|:...|..:......:.....:.::.|::::.||::|.|.....|.:::|||:..::.:.||.|
Human   161 EGWQFSHAFQITPSVAKKIAAVLTDSFPLKVRGIHLINEPVIFHAVFSMIKPFLTEKIKERIHMH 225

  Fly   217 LPN-ADTPYRHFPRSMLPEEYGGEAGKMSDLKLQWMQLLKEQRDYL 261
            ..| ..:..:||| .:||.|||||...|.|:..:|...:.:..|||
Human   226 GNNYKQSLLQHFP-DILPLEYGGEEFSMEDICQEWTNFIMKSEDYL 270

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3823	NP_572313.1	SEC14	90..239	CDD:238099	35/149 (23%)
TTPA	NP_000361.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		CRAL_TRIO_N	<40..73	CDD:215024	12/31 (39%)
		CRAL_TRIO	99..248	CDD:395525	37/159 (23%)
		Phosphatidylinositol 3,4-bisphosphate binding. /evidence=ECO:0000250\|UniProtKB:Q8BWP5	190..192		0/1 (0%)
		Phosphatidylinositol 4,5-bisphosphate binding. /evidence=ECO:0000250\|UniProtKB:Q8BWP5	208..211		0/2 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1471
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1053004at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10174
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920