DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12219 and ZNF160

DIOPT Version :9

Sequence 1:	NP_572312.1	Gene:	CG12219 / 31572	FlyBaseID:	FBgn0043796	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	NP_001096073.1	Gene:	ZNF160 / 90338	HGNCID:	12948	Length:	818	Species:	Homo sapiens

Alignment Length:	535	Identity:	113/535 - (21%)
Similarity:	168/535 - (31%)	Gaps:	167/535 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 CTEC---CSQLESFHNFWKLVELKQTTLCSQFLAIDCDVNWSEDGS----ETQLDAQPQLLLEPA 124
            |.||   .:|.....:.|::...::...|:     :|...:|...|    :|         :...
Human   371 CNECGKLFTQNSHLISHWRIHTGEKPYKCN-----ECGKAFSVRSSLAIHQT---------IHTG 421

  Fly   125 EEPKVVTPTTANKFPCMFCEKSFKMRRYLEEHIATHTGDRPIACPYCEMAFRCRSNMYTHVKSKH 189
            |:|          :.|..|.|.|:...||..|...|||::|..|..|..||...||:.||.....
Human   422 EKP----------YKCNECGKVFRYNSYLGRHRRVHTGEKPYKCNECGKAFSMHSNLATHQVIHT 476

  Fly   190 TTQWLKAREERDAAKSNQ---NHT---TPEETAPAVLVPVPAPAPALASAPASSASPGNTVNPAA 248
            .|:..|..|.......|.   ||.   |.|:       |........|.:..||.:....::..
Human   477 GTKPFKCNECSKVFTQNSQLANHRRIHTGEK-------PYKCNECGKAFSVRSSLTTHQAIHSG- 533

  Fly   249 TATPASSATPTTNLAAAPLPSPPTVQQLPLSVIKSQPSEAMNLTITKTPPSGSRGSRNRSSRRKT 313
                                              .:|.:.:....:.|..|..|      |.|..
Human   534 ----------------------------------EKPYKCIECGKSFTQKSHLR------SHRGI 558

  Fly   314 HSPKK-VQHTEGSDVSDEDSP----------QKRLKENELILANYNAVAAAVVAAASLTGNPPGQ 367
            ||.:| .:..|...|..:.|.          :|..|.|:...| ::..::.....|..||..|
Human   559 HSGEKPYKCNECGKVFAQTSQLARHWRVHTGEKPYKCNDCGRA-FSDRSSLTFHQAIHTGEKP-- 620

  Fly   368 PDSLQQRLCASLLQQQHQEQLFAVMSATAAAAAAVGT-----------------SSATTTTTTTT 415
               .:...|..:.  :|...|        |....:.|                 |:.||.....|
Human   621 ---YKCHECGKVF--RHNSYL--------ATHRRIHTGEKPYKCNECGKAFSMHSNLTTHKVIHT 672

  Fly   416 G-------------TMMAHPYGNHPPSETDKRP--------------AAPLQAVIHAAPVSIICP 453
            |             |..:| ..||..:.|.::|              :......||.......|.
Human   673 GEKPYKCNQCGKVFTQNSH-LANHQRTHTGEKPYRCNECGKAFSVRSSLTTHQAIHTGKKPYKCN 736

  Fly   454 NCGELPGQ-----NHRCL---SKPKYACDVCGKSFKMKRYLEEHFATHTGVKLHTCAFCPTEFRS 510
            .||::..|     |||.:   .|| |.|..|||:|:::..|..|.|.|||.|.:.|..|...||.
Human   737 ECGKVFTQNAHLANHRRIHTGEKP-YRCTECGKAFRVRSSLTTHMAIHTGEKRYKCNECGKVFRQ 800

  Fly   511 KSNMYHHTKRKHKAE 525
            .||:..| .|.|..|
Human   801 SSNLASH-HRMHTGE 814

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12219	NP_572312.1	zf-AD	2..94	CDD:285071	6/29 (21%)
		C2H2 Zn finger	140..160	CDD:275368	7/19 (37%)
		COG4049	149..204	CDD:226535	18/54 (33%)
		C2H2 Zn finger	168..186	CDD:275368	8/17 (47%)
		C2H2 Zn finger	473..493	CDD:275370	8/19 (42%)
		C2H2 Zn finger	501..522	CDD:275370	8/20 (40%)
ZNF160	NP_001096073.1	KRAB	8..68	CDD:214630
		KRAB	8..47	CDD:279668
		zf-C2H2	257..279	CDD:278523
		C2H2 Zn finger	259..279	CDD:275368
		zf-H2C2_2	271..295	CDD:290200
		C2H2 Zn finger	287..307	CDD:275368
		zf-H2C2_2	299..324	CDD:290200
		C2H2 Zn finger	315..335	CDD:275368
		zf-H2C2_2	327..350	CDD:290200
		C2H2 Zn finger	343..363	CDD:275368
		zf-H2C2_2	355..380	CDD:290200	3/8 (38%)
		COG5048	367..810	CDD:227381	110/529 (21%)
		C2H2 Zn finger	371..391	CDD:275368	5/19 (26%)
		C2H2 Zn finger	399..419	CDD:275368	5/33 (15%)
		zf-H2C2_2	411..436	CDD:290200	8/43 (19%)
		C2H2 Zn finger	427..447	CDD:275368	7/19 (37%)
		zf-H2C2_2	439..463	CDD:290200	10/23 (43%)
		C2H2 Zn finger	455..475	CDD:275368	8/19 (42%)
		C2H2 Zn finger	483..503	CDD:275368	4/19 (21%)
		zf-H2C2_2	496..519	CDD:290200	6/29 (21%)
		C2H2 Zn finger	511..531	CDD:275368	3/19 (16%)
		zf-H2C2_2	523..548	CDD:290200	2/59 (3%)
		C2H2 Zn finger	539..559	CDD:275368	5/25 (20%)
		zf-H2C2_2	551..576	CDD:290200	8/30 (27%)
		C2H2 Zn finger	567..587	CDD:275368	3/19 (16%)
		C2H2 Zn finger	595..615	CDD:275368	3/20 (15%)
		zf-H2C2_2	607..632	CDD:290200	5/31 (16%)
		C2H2 Zn finger	623..643	CDD:275368	4/29 (14%)
		zf-H2C2_2	635..659	CDD:290200	3/31 (10%)
		C2H2 Zn finger	651..671	CDD:275368	3/19 (16%)
		zf-H2C2_2	663..688	CDD:290200	4/24 (17%)
		C2H2 Zn finger	679..699	CDD:275368	4/20 (20%)
		zf-H2C2_2	691..715	CDD:290200	5/24 (21%)
		C2H2 Zn finger	707..727	CDD:275368	0/19 (0%)
		zf-H2C2_2	719..744	CDD:290200	5/24 (21%)
		C2H2 Zn finger	735..755	CDD:275368	7/19 (37%)
		zf-H2C2_2	747..770	CDD:290200	10/23 (43%)
		C2H2 Zn finger	763..783	CDD:275368	8/19 (42%)
		zf-H2C2_2	775..800	CDD:290200	10/24 (42%)
		C2H2 Zn finger	791..811	CDD:275368	8/20 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142342
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930