DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12219 and ZNF665

DIOPT Version :9

Sequence 1:	NP_572312.1	Gene:	CG12219 / 31572	FlyBaseID:	FBgn0043796	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	NP_001340387.1	Gene:	ZNF665 / 79788	HGNCID:	25885	Length:	706	Species:	Homo sapiens

Alignment Length:	469	Identity:	99/469 - (21%)
Similarity:	141/469 - (30%)	Gaps:	150/469 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   130 VTPTTANKFPCMFCEKSFKMRRYLEEHIATHTGDRPIACPYCEMAFRCRSNMYTHVKSKHTTQWL 194
            |..|....:.|..|.|.|....:|..|...|||::|..|..|..||..||::.|| ::.||.:
Human   310 VIHTGEKPYKCKECGKCFTQNSHLASHRRIHTGEKPYKCNECGKAFSVRSSLTTH-QTIHTGE-- 371

  Fly   195 KA----------REERDAAKSNQNHTTPEETAPAVLVPVPAPAPALASAPASSASPGNTVNPAAT 249
            |.          |.....||..:.||                    ...|......|...:..:.
Human   372 KPYKCNECGKVFRHNSYLAKHRRIHT--------------------GEKPYKCNECGKAFSMHSN 416

  Fly   250 ATPASSATPTTNLAAAPLPSPPTVQQLPLSVIKSQPSEAMNLTITKTPPSGSRGSRNRSSRRKTH 314
            .|...    ..:....|......|:      :.:|.|...|                   .|:.|
Human   417 LTKHQ----IIHTGEKPFKCNECVK------VFTQYSHLAN-------------------HRRIH 452

  Fly   315 SPKKVQHTE--GSDVSDEDS---------PQKRLKENEL--------ILANYNAVAAAVVAAASL 360
            :.:|....:  |...|...|         .:|..|.|:.        .||::..:.
Human   453 TGEKPYRCDECGKAFSVRSSLTTHQAIHTGEKPYKCNDCGKVFTQNSHLASHRGIH--------- 508

  Fly   361 TGNPPGQPDSLQQRLCASLLQQQHQ----------EQLFAVMSATAAAAAAVGTSSATTTTTTTT 415
            :|..|.:.|.     |.....|..|          |:.:.......|.:.   .||.|...|..|
Human   509 SGEKPYKCDE-----CGKAFSQTSQLARHWRVHTGEKPYKCNECGKAFSV---HSSLTIHQTIHT 565

  Fly   416 GTMMAHPY---------------GNHPPSETDKRP--------------AAPLQAVIHAAPVSII 451
            |   ..||               ..|....|.::|              ......|||.......
Human   566 G---QKPYKCNDCGKVFRHNSYLAIHQRIHTGEKPYKCNECGKAFSVHSNLATHQVIHTGEKPYK 627

  Fly   452 CPNCGELPGQ-----NHRCL---SKPKYACDVCGKSFKMKRYLEEHFATHTGVKLHTCAFCPTEF 508
            |..||::..|     |||.:   .|| |.|:.|||:|.::..|..|.|.|||.|.:.|..|...|
Human   628 CNECGKVFTQNSHLANHRRIHTGEKP-YRCNECGKAFSVRSTLTTHMAVHTGDKPYKCNQCGKVF 691

  Fly   509 RSKSNMYHHTKRKH 522
            ...||:..| :|.|
Human   692 TQNSNLAKH-RRIH 704

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12219	NP_572312.1	zf-AD	2..94	CDD:285071
		C2H2 Zn finger	140..160	CDD:275368	6/19 (32%)
		COG4049	149..204	CDD:226535	18/64 (28%)
		C2H2 Zn finger	168..186	CDD:275368	8/17 (47%)
		C2H2 Zn finger	473..493	CDD:275370	8/19 (42%)
		C2H2 Zn finger	501..522	CDD:275370	7/20 (35%)
ZNF665	NP_001340387.1	KRAB	37..76	CDD:307490
		COG5048	192..580	CDD:227381	63/341 (18%)
		C2H2 Zn finger	208..228	CDD:275368
		C2H2 Zn finger	236..256	CDD:275368
		C2H2 Zn finger	264..284	CDD:275368
		C2H2 Zn finger	292..312	CDD:275368	1/1 (100%)
		C2H2 Zn finger	320..340	CDD:275368	6/19 (32%)
		C2H2 Zn finger	348..368	CDD:275368	8/20 (40%)
		C2H2 Zn finger	376..396	CDD:275368	3/19 (16%)
		C2H2 Zn finger	404..424	CDD:275368	2/23 (9%)
		C2H2 Zn finger	432..452	CDD:275368	5/44 (11%)
		C2H2 Zn finger	460..480	CDD:275368	3/19 (16%)
		C2H2 Zn finger	488..508	CDD:275368	3/19 (16%)
		C2H2 Zn finger	516..536	CDD:275368	4/24 (17%)
		C2H2 Zn finger	544..564	CDD:275368	5/22 (23%)
		C2H2 Zn finger	572..592	CDD:275368	1/19 (5%)
		zf-H2C2_2	584..608	CDD:316026	3/23 (13%)
		C2H2 Zn finger	600..620	CDD:275368	1/19 (5%)
		zf-H2C2_2	612..637	CDD:316026	6/24 (25%)
		C2H2 Zn finger	628..648	CDD:275368	7/19 (37%)
		zf-H2C2_2	640..664	CDD:316026	10/24 (42%)
		C2H2 Zn finger	656..676	CDD:275368	8/19 (42%)
		zf-H2C2_2	669..693	CDD:316026	10/23 (43%)
		C2H2 Zn finger	684..704	CDD:275368	7/20 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142343
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930