DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12219 and ZNF99

DIOPT Version :9

Sequence 1:	NP_572312.1	Gene:	CG12219 / 31572	FlyBaseID:	FBgn0043796	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	NP_001073878.2	Gene:	ZNF99 / 7652	HGNCID:	13175	Length:	864	Species:	Homo sapiens

Alignment Length:	444	Identity:	90/444 - (20%)
Similarity:	132/444 - (29%)	Gaps:	150/444 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   133 TTANKFPCMFCEKSFKMRRYLEEHIATHTGDRPIACPYCEMAFRCRSNMYTHVKSKHTTQWLKAR 197
            |....:.|..|.|:||...:|..|.|.|||::|..|..|..||...|.:..| :..||.:.....
Human   280 TGKKPYKCEECGKAFKQSSHLTRHKAIHTGEKPYKCEECGKAFNHFSALRKH-QIIHTGKKPYKC 343

  Fly   198 EERDAAKSNQN--------HTTP-----EETAPAVLVPVPAPAPALASAPASSASPGNTVNPAAT 249
            ||...|.|..:        ||..     ||...|.
Human   344 EECGKAFSQSSTLRKHEIIHTEEKPYKYEECGKAF------------------------------ 378

  Fly   250 ATPASSATPTTNLAAAPLPSPPTVQQLPLSVIKSQPSEAM----NLTITKTPPSGSRGSR----- 305
                      :||:|..........|.|...  .:..:|.    .||:.|...:..:..:
Human   379 ----------SNLSALRKHEIIHTGQKPYKC--EECGKAFKWSSKLTVHKVIHTAEKPCKCEECG 431

  Fly   306 ---NRSSRRKTHSPKKVQHTEGSDVSDEDSPQKRLKENELILANYNAVAAAVVAAASLTGNPPGQ 367
               .|.|..:.|   |:.||       ...|.| .:|.....:|::|:....:..   ||..|.:
Human   432 KAFKRFSALRKH---KIIHT-------GKQPYK-CEECSKAFSNFSALRKHEIIH---TGEKPYK 482

  Fly   368 PDSLQQRLCASLLQQQHQEQLFAVMSATAAAAAAVGTSSATTTTTTTTGTMMAHPYGNHPPSETD 432
            .:.     |..                      |...||..|.               |.....:
Human   483 CEE-----CGK----------------------AFKWSSKLTV---------------HKVIHME 505

  Fly   433 KRP--------------AAPLQAVIHAAPVSIICPNCGELPGQN-----HRCL--SKPKYACDVC 476
            ::|              |.....:||.......|..||:....:     |:.:  .|..|.|:.|
Human   506 EKPCKCEECGKAFKHFSALRKHKIIHTGKKPYKCEECGKAFNNSSTLMKHKIIHTGKKPYKCEEC 570

  Fly   477 GKSFKMKRYLEEHFATHTGVKLHTCAFCPTEFR-----SKSNMYHHTKRKHKAE 525
            ||:||...:|..|.|.|||.|.:.|..|...|.     .|..:.|..|:.:|.|
Human   571 GKAFKQSSHLTRHKAIHTGEKPYKCEECGKAFNHFSALRKHQIIHTGKKPYKCE 624

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12219	NP_572312.1	zf-AD	2..94	CDD:285071
		C2H2 Zn finger	140..160	CDD:275368	8/19 (42%)
		COG4049	149..204	CDD:226535	17/54 (31%)
		C2H2 Zn finger	168..186	CDD:275368	6/17 (35%)
		C2H2 Zn finger	473..493	CDD:275370	9/19 (47%)
		C2H2 Zn finger	501..522	CDD:275370	6/25 (24%)
ZNF99	NP_001073878.2	KRAB	4..64	CDD:214630
		KRAB	4..43	CDD:279668
		C2H2 Zn finger	147..167	CDD:275368
		C2H2 Zn finger	175..195	CDD:275368
		C2H2 Zn finger	203..223	CDD:275368
		C2H2 Zn finger	232..251	CDD:275368
		C2H2 Zn finger	259..279	CDD:275368
		COG5048	267..684	CDD:227381	90/444 (20%)
		zf-H2C2_2	272..296	CDD:290200	5/15 (33%)
		C2H2 Zn finger	287..307	CDD:275368	8/19 (42%)
		zf-H2C2_2	299..324	CDD:290200	11/24 (46%)
		C2H2 Zn finger	315..335	CDD:275368	6/20 (30%)
		zf-H2C2_2	327..352	CDD:290200	6/25 (24%)
		C2H2 Zn finger	343..363	CDD:275368	4/19 (21%)
		C2H2 Zn finger	371..391	CDD:275368	6/59 (10%)
		zf-H2C2_2	383..407	CDD:290200	4/25 (16%)
		C2H2 Zn finger	399..419	CDD:275368	4/21 (19%)
		C2H2 Zn finger	427..447	CDD:275368	4/22 (18%)
		C2H2 Zn finger	455..475	CDD:275368	3/19 (16%)
		zf-H2C2_2	467..491	CDD:290200	6/53 (11%)
		C2H2 Zn finger	483..503	CDD:275368	6/61 (10%)
		C2H2 Zn finger	511..531	CDD:275368	1/19 (5%)
		zf-H2C2_2	523..548	CDD:290200	6/24 (25%)
		COG5048	534..857	CDD:227381	27/91 (30%)
		C2H2 Zn finger	539..559	CDD:275368	4/19 (21%)
		zf-H2C2_2	552..576	CDD:290200	8/23 (35%)
		C2H2 Zn finger	567..587	CDD:275368	9/19 (47%)
		zf-H2C2_2	579..604	CDD:290200	10/24 (42%)
		C2H2 Zn finger	595..615	CDD:275368	4/19 (21%)
		zf-H2C2_2	607..632	CDD:290200	5/18 (28%)
		C2H2 Zn finger	623..643	CDD:275368	1/2 (50%)
		zf-H2C2_2	636..659	CDD:290200
		C2H2 Zn finger	651..671	CDD:275368
		zf-H2C2_2	663..688	CDD:290200
		C2H2 Zn finger	679..699	CDD:275368
		zf-H2C2_2	691..716	CDD:290200
		C2H2 Zn finger	707..727	CDD:275368
		zf-H2C2_2	720..743	CDD:290200
		C2H2 Zn finger	735..755	CDD:275368
		C2H2 Zn finger	763..783	CDD:275368
		zf-H2C2_2	775..800	CDD:290200
		C2H2 Zn finger	791..811	CDD:275368
		C2H2 Zn finger	819..839	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142243
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930