Protein Alignment CG12219 and ZNF84

DIOPT Version :10

• Sequence 1: NP_572312.1
• Gene: CG12219 / 31572
• FlyBaseID: FBgn0043796
• Length: 562
• Species: Drosophila melanogaster
• Sequence 2: NP_003419.3
• Gene: ZNF84 / 7637
• HGNCID: 13159
• Length: 738
• Species: Homo sapiens
• Alignment Length: 589
• Identity: 127/589 - (21%)
• Similarity: 198/589 - (33%)
• Gaps: 151/589 - (25%)

  Fly    30 PDDED------DGKAMPESY-LVQLISIH-------LYLCLS-------------------RDDA 61
            |:|.|      |.....||| ..|:|..|       ||.|..                   ||.|
Human   170 PEDTDTWLKYYDCDKYKESYKKSQIIIYHRNRLGEKLYECSECRKRFSKKPSLIKHQSRHIRDIA 234

  Fly    62 ISTCICTECCSQLESFHNFWKLVELKQTTLCSQFLAIDCDVNWSEDGSETQLDAQPQLLLEPAEE 126
            .....|.:...|...|....:....::...|||     |...:|:   ::||.:..:
Human   235 FGCGNCGKTFPQKSQFITHHRTHTGEKPYNCSQ-----CGKAFSQ---KSQLTSHQR-------- 283

  Fly   127 PKVVTPTTANKFPCMFCEKSFKMRRYLEEHIATHTGDRPIACPYCEMAFRCRSNMYTHVKSKHTT 191
                |.|....:.|..|.|:|..:.:|..|..||||::|..|..|..||..:||:..|.:. ||.
Human   284 ----THTGEKPYECGECGKAFSRKSHLISHWRTHTGEKPYGCNECGRAFSEKSNLINHQRI-HTG 343

  Fly   192 QWLKAREERDAAKS----------NQNHTTPEETAPAVLVPVPAPAPALASAPASSASPGNTVNP 246
            :  |..|.|:..|:          ::.||..:        |........|....|......|::.
Human   344 E--KPFECRECGKAFSRKSQLVTHHRTHTGTK--------PFGCSDCRKAFFEKSELIRHQTIHT 398

  Fly   247 AATATPASSATPTTNLAAAPLPSPPT-VQQLPLSVIK-----SQPSEAMNLTITKT---PPSGSR 302
            .......|.........::.:....| ..:.|...|:     ||.|..::..:|.|   |...|:
Human   399 GEKPYECSECRKAFRERSSLINHQRTHTGEKPHGCIQCGKAFSQKSHLISHQMTHTGEKPFICSK 463

  Fly   303 GSR--NRSSRRKTHSPKKVQHTEGSDVSDEDSPQKRLKENELILANYNAVAAAVVAAASLTGNPP 365
            ..:  :|.|:...|     |.|...:...|.|...:....:|.|.|:..:.         ||..|
Human   464 CGKAFSRKSQLVRH-----QRTHTGEKPYECSECGKAFSEKLSLTNHQRIH---------TGEKP 514

  Fly   366 GQPDSLQQRLCASLLQQQHQ-----EQLFAVMSATAAAAAAVGTSSATTTTTTTTGTMMAHPYGN 425
            .......:..|.......||     |:.:    ..:....|.|..|:..|
Human   515 YVCSECGKAFCQKSHLISHQRTHTGEKPY----ECSECGKAFGEKSSLAT--------------- 560

  Fly   426 HPPSETDKRPAAPLQAVIHAAPVSIICPNCGELPGQ-----NHRCL---SKPKYACDVCGKSFKM 482
            |..:.|.::|..              |.:|.:...|     .|:.:   .|| |.|.:|.|:|..
Human   561 HQRTHTGEKPYE--------------CRDCEKAFSQKSQLNTHQRIHTGEKP-YECSLCRKAFFE 610

  Fly   483 KRYLEEHFATHTGVKLHTCAFCPTEFRSKSNMYHHTKRKHKAE--WERSRATRSAAKAG--VQEQ 543
            |..|..|..||||.|.:.|..|...||.||::.:| :|.|..|  :|.|...::.::..  :..|
Human   611 KSELIRHLRTHTGEKPYECNECRKAFREKSSLINH-QRIHTGEKPFECSECGKAFSRKSHLIPHQ 674

  Fly   544 MQHT 547
            ..||
Human   675 RTHT 678

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12219	NP_572312.1	zf-AD	2..91	CDD:214871	19/93 (20%)
		PHA00733	<117..189	CDD:177301	20/71 (28%)
		C2H2 Zn finger	140..160	CDD:275368	6/19 (32%)
		zf-H2C2_2	152..177	CDD:463886	11/24 (46%)
		C2H2 Zn finger	168..186	CDD:275368	7/17 (41%)
		C2H2 Zn finger	473..493	CDD:275370	7/19 (37%)
		C2H2 Zn finger	501..522	CDD:275370	8/20 (40%)
ZNF84	NP_003419.3	KRAB	9..68	CDD:214630
		C2H2 Zn finger	209..229	CDD:275368	1/19 (5%)
		C2H2 Zn finger	237..257	CDD:275368	3/19 (16%)
		zf-C2H2	263..285	CDD:395048	7/41 (17%)
		C2H2 Zn finger	265..285	CDD:275368	7/39 (18%)
		zf-H2C2_2	278..302	CDD:463886	7/35 (20%)
		C2H2 Zn finger	293..313	CDD:275368	6/19 (32%)
		COG5048	317..724	CDD:227381	89/422 (21%)
		C2H2 Zn finger	321..341	CDD:275368	7/20 (35%)
		C2H2 Zn finger	349..369	CDD:275368	2/19 (11%)
		C2H2 Zn finger	377..397	CDD:275368	3/19 (16%)
		C2H2 Zn finger	405..425	CDD:275368	1/19 (5%)
		C2H2 Zn finger	433..453	CDD:275368	4/19 (21%)
		C2H2 Zn finger	461..481	CDD:275368	5/24 (21%)
		C2H2 Zn finger	489..509	CDD:275368	4/19 (21%)
		C2H2 Zn finger	517..537	CDD:275368	3/19 (16%)
		C2H2 Zn finger	545..565	CDD:275368	5/34 (15%)
		C2H2 Zn finger	573..593	CDD:275368	4/19 (21%)
		C2H2 Zn finger	601..621	CDD:275368	7/19 (37%)
		C2H2 Zn finger	629..649	CDD:275368	8/20 (40%)
		C2H2 Zn finger	657..677	CDD:275368	2/19 (11%)
		C2H2 Zn finger	685..705	CDD:275368
		C2H2 Zn finger	713..733	CDD:275368