Protein Alignment CG12219 and ZNF407

DIOPT Version :10

• Sequence 1: NP_572312.1
• Gene: CG12219 / 31572
• FlyBaseID: FBgn0043796
• Length: 562
• Species: Drosophila melanogaster
• Sequence 2: NP_060227.2
• Gene: ZNF407 / 55628
• HGNCID: 19904
• Length: 2248
• Species: Homo sapiens
• Alignment Length: 559
• Identity: 114/559 - (20%)
• Similarity: 181/559 - (32%)
• Gaps: 152/559 - (27%)

  Fly    95 FLAIDCDVNWSEDGSETQLDAQPQLLLEPAE--EPKVVTPTTANKFPCMFCEKSFKMRRYLEEHI 157
            |.::|.:||......:.|:.::|:...:|.:  ..:.||.|..||  |:.||.|......||.|:
Human   974 FHSLDGEVNSHLLDKKEQISSEPEDFAQPGDVYSQRDVTGTGENK--CLHCEFSAHSSASLELHV 1036

  Fly   158 -ATHTGDRPIACPYCEMAFRCRSNMYTHV-----KSKHTTQWLKAREERDAAKSNQNHTTPEE-- 214
             ..||.:....|..|:.....|..|..|.     |.|..:....|..|..:|..::|...|||
Human  1037 KRKHTKEFEFYCMACDYYAVTRREMTRHAATEKHKMKRQSYLNSANVEAGSADMSKNIIMPEEEH 1101

  Fly   215 ---TAPAVLVPVPAPAPALASAPASSASPGNTVNPAATATPASSATPTTNLAAAPLPSP------ 270
               :....::               |..|.:|:. :..|...|.....|||..:.:...
Human  1102 QQNSEEFQII---------------SGQPSDTLK-SRNAADCSILNENTNLDMSKVLCAADSVEV 1150

  Fly   271 ---------------PTVQQLPLSVIKSQPSEAMNLTITKT--PPSGSRGSRNRSSRRKTHSPKK 318
                           .|.||.|:.....:|.|.|:||::..  .||..:...:.||.....:.||
Human  1151 ETEEESNFNEDHSFCETFQQAPVKDKVRKPEEMMSLTMSSNYGSPSRFQNENSGSSALNCETAKK 1215

  Fly   319 VQ-----------HTEGSDVSDEDS----PQKRLKENELILANYNAVAAAVVAAASLTGNPPGQP 368
            ..           |.||...:..|.    |.:.|  ..:.|....:..:.|:....:|.......
Human  1216 NHEISNDAGELRVHCEGEGGNAGDGGGVVPHRHL--CPVTLDGERSAESPVLVVTRITREQGNLE 1278

  Fly   369 DSLQQRLCAS--------------------LLQQQHQEQLFAVMSATAAAAAAVGTSSA--TTTT 411
            ...|.|:...                    |:..||:.: |.:.....|:.:.|.:|..  |..:
Human  1279 SGGQNRVARGHGLEDLKGVQEDPVLGNKEILMNSQHETE-FILEEDGPASDSTVESSDVYETIIS 1342

  Fly   412 TTTTGTMMAHPYG----------NHPPSETDKRPAAPLQAV---IHAAPVS-------------- 449
            ....|..| :.:|          |....|...:....|.|.   |...|:.
Human  1343 IDDKGQAM-YSFGRFDSSIIRIKNPEDGELIDQSEEGLIATGVRISELPLKDCAQGVKKKKSEGS 1406

  Fly   450 -------IICPNCG----ELPGQN-HRCLSKP----KYACDVCGKSFKMKRYLEEHFAT--H--- 493
                   |.|.:||    .|.|.| |..:..|    .:.|.:|||||..:..|.:|.|:  |
Human  1407 SIGESTRIRCDDCGFLADGLSGLNVHIAMKHPTKEKHFHCLLCGKSFYTESNLHQHLASAGHMRN 1471

  Fly   494 ---------TGVKLHTCAFCPTEFRSKSNMYHHTKRKHK 523
                     .|.....|..|...|.|:.|::.|.|.:|:
Human  1472 EQASVEELPEGGATFKCVKCTEPFDSEQNLFLHIKGQHE 1510

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12219	NP_572312.1	zf-AD	2..91	CDD:214871
		PHA00733	<117..189	CDD:177301	22/79 (28%)
		C2H2 Zn finger	140..160	CDD:275368	7/20 (35%)
		zf-H2C2_2	152..177	CDD:463886	7/25 (28%)
		C2H2 Zn finger	168..186	CDD:275368	5/22 (23%)
		C2H2 Zn finger	473..493	CDD:275370	9/21 (43%)
		C2H2 Zn finger	501..522	CDD:275370	7/20 (35%)
ZNF407	NP_060227.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..84
		C2H2 Zn finger	188..208	CDD:275368
		C2H2 Zn finger	217..238	CDD:275368
		C2H2 Zn finger	246..268	CDD:275368
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	291..322
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	494..515
		C2H2 Zn finger	590..614	CDD:275371
		C2H2 Zn finger	617..639	CDD:275371
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	667..700
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	821..847
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	910..962
		C2H2 Zn finger	1416..1445	CDD:275371	8/28 (29%)
		C2H2 Zn finger	1446..1468	CDD:275371	9/21 (43%)
		C2H2 Zn finger	1488..1509	CDD:275371	7/20 (35%)
		C2H2 Zn finger	1539..1561	CDD:275368
		zf-H2C2_2	1557..1578	CDD:463886
		C2H2 Zn finger	1569..1589	CDD:275368
		C2H2 Zn finger	1597..1617	CDD:275368
		C2H2 Zn finger	1630..1650	CDD:275368
		zf-H2C2_2	1642..1669	CDD:463886
		C2H2 Zn finger	1658..1680	CDD:275368
		C2H2 Zn finger	1688..1708	CDD:275368
		zf-H2C2_2	1700..1725	CDD:463886
		zf-H2C2_5	1714..1738	CDD:404746
		C2H2 Zn finger	1716..1736	CDD:275368
		zf-H2C2_2	1728..1753	CDD:463886
		C2H2 Zn finger	1744..1761	CDD:275368