DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12219 and ZNF107

DIOPT Version :9

Sequence 1:	NP_572312.1	Gene:	CG12219 / 31572	FlyBaseID:	FBgn0043796	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	NP_001374954.1	Gene:	ZNF107 / 51427	HGNCID:	12887	Length:	896	Species:	Homo sapiens

Alignment Length:	421	Identity:	91/421 - (21%)
Similarity:	132/421 - (31%)	Gaps:	110/421 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   133 TTANKFPCMFCEKSFKMRRYLEEHIATHTGDRPIACPYCEMAFRCRSNMYTHVKSKHTTQWLKAR 197
            |..|.:.|..|.|:|.....|.:|...|||::|..|..|..||. :|:..|..|..||.:.....
Human   240 TRVNSYKCEECGKAFNWFSTLTKHKRIHTGEKPYKCEECGKAFN-QSSQLTRHKIIHTEEKPNKC 303

  Fly   198 EERDAAKSNQNHTTPEETAPAVLVPVPAPAPALASAPASSASPGNTVNPAATATPASSATPTTNL 262
            ||...|....:|.|..:.......|..........:.:|..:....::...............||
Human   304 EECGKAFKQASHLTIHKIIHTGEKPYKYEECGKVFSQSSHLTTQKILHTGENLYKCKECGKAFNL 368

  Fly   263 AAAPLPSPPTVQQLPLSVIKSQPSEAMNLTITKTPPSGSRG------------SRNRSSRRKTHS 315
            .:                         |||..|...:|.:.            |.|.:.:.|.|:
Human   369 FS-------------------------NLTNHKRIHAGEKPYKCKECGRAFNISSNLNKQEKIHT 408

  Fly   316 PKKVQHTEGSDVSDEDSPQKRLKENELILANYNAVAAAVVAAASLTGNPPGQPDSLQQRLCASLL 380
            ..|:...|..|.:...|  .:|..::.||..                   .:|...::  |..:.
Human   409 GGKLNKCEECDKAFNRS--LKLTAHKKILME-------------------EKPYKCEE--CGKVF 450

  Fly   381 QQQHQEQLFAVMSATAAAAAAVGTSSATTTTTTTTGTMMAHPYG--------NHPPSETDKRPAA 437
            .|                     .|:.|......||   ..||.        |...:.|:.:.
Human   451 NQ---------------------FSTLTRHKIIHTG---EKPYKCKECGKAFNQSSNLTEHKK-- 489

  Fly   438 PLQAVIHAAPVSIICPNCGELPGQ-----NHRCL---SKPKYACDVCGKSFKMKRYLEEHFATHT 494
                 ||.|..|..|..||:...|     |||.:   .|| |.|:.|||:|.....|..|...||
Human   490 -----IHTAEKSYKCEECGKAFNQHSNLINHRKIYSGEKP-YKCEECGKAFNRSSTLTRHKKIHT 548

  Fly   495 GVKLHTCAFCPTEFRSKSNMYHHTKRKHKAE 525
            |.|.:.|..|...|...||:..| |:.|..|
Human   549 GEKPYKCEECDRAFSQSSNLTEH-KKIHTGE 578

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12219	NP_572312.1	zf-AD	2..94	CDD:285071
		C2H2 Zn finger	140..160	CDD:275368	6/19 (32%)
		COG4049	149..204	CDD:226535	17/54 (31%)
		C2H2 Zn finger	168..186	CDD:275368	6/17 (35%)
		C2H2 Zn finger	473..493	CDD:275370	7/19 (37%)
		C2H2 Zn finger	501..522	CDD:275370	7/20 (35%)
ZNF107	NP_001374954.1	KRAB	48..108	CDD:214630
		C2H2 Zn finger	191..211	CDD:275368
		C2H2 Zn finger	219..239	CDD:275368
		COG5048	243..621	CDD:227381	90/418 (22%)
		C2H2 Zn finger	247..267	CDD:275368	6/19 (32%)
		C2H2 Zn finger	275..295	CDD:275368	7/20 (35%)
		C2H2 Zn finger	303..323	CDD:275368	5/19 (26%)
		C2H2 Zn finger	331..351	CDD:275368	1/19 (5%)
		C2H2 Zn finger	359..379	CDD:275368	6/44 (14%)
		C2H2 Zn finger	387..407	CDD:275368	3/19 (16%)
		C2H2 Zn finger	415..435	CDD:275368	4/21 (19%)
		C2H2 Zn finger	443..463	CDD:275368	4/42 (10%)
		C2H2 Zn finger	471..491	CDD:275368	2/26 (8%)
		C2H2 Zn finger	499..519	CDD:275368	7/19 (37%)
		C2H2 Zn finger	527..547	CDD:275368	7/19 (37%)
		COG5048	551..>863	CDD:227381	10/29 (34%)
		C2H2 Zn finger	555..575	CDD:275368	7/20 (35%)
		C2H2 Zn finger	583..603	CDD:275368
		C2H2 Zn finger	611..631	CDD:275368
		C2H2 Zn finger	639..659	CDD:275368
		C2H2 Zn finger	699..715	CDD:275368
		C2H2 Zn finger	723..743	CDD:275368
		C2H2 Zn finger	751..771	CDD:275368
		C2H2 Zn finger	779..799	CDD:275368
		C2H2 Zn finger	807..827	CDD:275368
		C2H2 Zn finger	835..855	CDD:275368
		C2H2 Zn finger	863..883	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142194
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930