DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12219 and hang

DIOPT Version :9

Sequence 1:	NP_572312.1	Gene:	CG12219 / 31572	FlyBaseID:	FBgn0043796	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	NP_001138204.1	Gene:	hang / 32613	FlyBaseID:	FBgn0026575	Length:	2223	Species:	Drosophila melanogaster

Alignment Length:	703	Identity:	123/703 - (17%)
Similarity:	206/703 - (29%)	Gaps:	278/703 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 CRLCLNALDEQSAVLLFDGAGGASAPAPDDEDDGKAMPESYLVQLISIHLYLC----LSRDDAIS 63
            ||||:....|..:::        ::.|.|.|.             :|..::.|    ::..|.:|
  Fly    81 CRLCIAPQTECISII--------NSYAADKEP-------------LSTKIHNCVGIKVTPQDRLS 124

  Fly    64 TCICTECCSQLESFHNF-------------WKLVELKQTTLCSQFLAIDCDVNWSEDGS----ET 111
            ..||..|.|.|.|:.:|             |  ::..::.|.:..     |:|.:|:|.    :.
  Fly   125 QQICHACISYLNSWQSFKNRCFSSQAKQRQW--LDTNKSKLLNYL-----DLNSAENGGGGFFDQ 182

  Fly   112 QLDAQPQ----LLLEPAEEPKVVTPTTANKFPCMFCE-KSFKMRRYLEEHIA-------THTGDR 164
            .|..|.|    |..|...|.:..|||.|:....:... .|.|.|:.|..:::       .|...:
  Fly   183 HLHQQQQHHQHLENELEAEKEKATPTAASTAANILDGIHSLKKRKSLTVYVSPKPQQMQQHQLQQ 247

  Fly   165 PIACPYCEM----------------------AFRCRSNMYTHVKSKHTTQWLKAREERDAAKSNQ 207
            ....|...|                      |..|.|.      |..||...:.||::...:..|
  Fly   248 LQLQPPARMTATISSAQQSLQTLLLQVPASAAASCSST------STSTTSASQQREQQQHQQRQQ 306

  Fly   208 NHT--------------------------------------------TPEETAPAVLVPVPAPAP 228
            :|.                                            .|:...|   |||..|||
  Fly   307 SHQYRRYHHHHQQQQQQQQQQHNQRGKQMLPHHQQHQQQHHRRQRQFRPQRPLP---VPVVNPAP 368

  Fly   229 ALASAPASSASPGNTVNPAATATPASSATPT-TNLAAAPLPSPPTVQQLP--LSVIKSQPSEAMN 290
            .|.........|.:...|.....|...:.|| ..:....:..||..:.||  ..|.....|.:::
  Fly   369 TLRKFKPKLYLPLDITVPPLPPLPTIPSIPTLPPVGPGSIAPPPAAELLPGISGVAGMVESLSLS 433

  Fly   291 LTITKTPPSGSRGSRNRSSRRKTHSPKKVQHTEGSDVSDEDSPQKRLKENELILANYNAVAAAVV 355
            |.:..:....|.|              .|||.:                            |..:
  Fly   434 LPLDFSQSCSSSG--------------HVQHQQ----------------------------AGGL 456

  Fly   356 AAASLTGNPPGQPDSLQQRLCASLLQQQHQEQLFAVMSATAAAAAAVGTSSATTTTTTTTGTMMA 420
            |.::.|.||||                       :|:|||.:|:.   ::||:.:.:.:|..::.
  Fly   457 ATSTTTSNPPG-----------------------SVVSATPSASV---SASASASASVSTAPLLM 495

  Fly   421 HPYGNHP----PSETDK--------------RPAAPLQAVIHAAPVSIICPNCGELPGQNHRCLS 467
            .|....|    |.:||.              .|...|:...|.          |::|      |:
  Fly   496 PPLPAMPIKDEPIDTDDDYQMKSIDESDDMVDPTMFLERSEHE----------GDVP------LT 544

  Fly   468 KPKYACDVCGKSFKMKRYLEEHFATHTGV------------------KLHTCAFCPTEFRSKSNM 514
            ...|            .|..:|....:.|                  |:.:|..|..:|.:::|.
  Fly   545 ASDY------------DYTAQHGVNASSVAASLPPNAVANVAAAGDSKVASCRACSLQFSTRANA 597

  Fly   515 YHHTKRKHKAEWERSR-------ATRSAAKAGVQEQMQHTNPSQAQAQPGPAA 560
            ..|.:..|...::.|.       .|:.........:||....:.|.|:...||
  Fly   598 RRHERNLHPNLFQLSTDSPHNTPITKPTPALAAALEMQRAAAAAATAEANRAA 650

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12219	NP_572312.1	zf-AD	2..94	CDD:285071	21/107 (20%)
		C2H2 Zn finger	140..160	CDD:275368	4/27 (15%)
		COG4049	149..204	CDD:226535	13/83 (16%)
		C2H2 Zn finger	168..186	CDD:275368	5/39 (13%)
		C2H2 Zn finger	473..493	CDD:275370	2/19 (11%)
		C2H2 Zn finger	501..522	CDD:275370	5/20 (25%)
hang	NP_001138204.1	zf-AD	80..154	CDD:285071	19/93 (20%)
		C2H2 Zn finger	1036..1057	CDD:275368
		C2H2 Zn finger	1067..1088	CDD:275368
		C2H2 Zn finger	1279..1298	CDD:275371
		C2H2 Zn finger	1308..1325	CDD:275371
		C2H2 Zn finger	1420..1440	CDD:275368
		C2H2 Zn finger	1450..1468	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45455472
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930