Protein Alignment CG3815 and PHF12

DIOPT Version :10

• Sequence 1: NP_572311.1
• Gene: CG3815 / 31571
• FlyBaseID: FBgn0029861
• Length: 878
• Species: Drosophila melanogaster
• Sequence 2: NP_001028733.1
• Gene: PHF12 / 57649
• HGNCID: 20816
• Length: 1004
• Species: Homo sapiens
• Alignment Length: 1029
• Identity: 295/1029 - (28%)
• Similarity: 440/1029 - (42%)
• Gaps: 249/1029 - (24%)

  Fly     7 DPNASLSIMEQIKQLIRPPPNEDEKMMQRSTNTKHPYYRRPGRGHNHDYCDACEEGGNLLCCDRC 71
            |.:.|..:||||:.|:.||..::.:...|... |.|  ||.||..|||.||:|:|||:|||||.|
Human    13 DLDTSGGLMEQIQALLAPPKTDEAEKRSRKPE-KEP--RRSGRATNHDSCDSCKEGGDLLCCDHC 74

  Fly    72 PSSFHLQCHDPPLSEEDIPSGQWLCHSC--RMSKLSQPPASSSKASSVERVPSAGSGSRANTPSS 134
            |::|||||.:||||||.:|.|:|:||.|  |..|..|..........|::     ||.|..:|||
Human    75 PAAFHLQCCNPPLSEEMLPPGEWMCHRCTVRRKKREQKKELGHVNGLVDK-----SGKRTTSPSS 134

  Fly   135 G-----------DLESIPLKIRNLRKRSNSERNSTEKLLAKMPMSIQR-----ALDPNKKPT--- 180
            .           :|::| ...|.|.:|::.....|.....:.|.|.|.     .:|.:::|.
Human   135 DTDLLDRSASKTELKAI-AHARILERRASRPGTPTSSASTETPTSEQNDVDEDIIDVDEEPVAAE 198

  Fly   181 ----------PLDDVIRAATMMNPQQFSLPPELELHTQFPGNGKVQPVQQTHPPSGNGGNRRCAG 235
                      |.:.:|.||...||.||.||.||...|..||:.|.:..::|     .|.|.:
Human   199 PDYVQPQLRRPFELLIAAAMERNPTQFQLPNELTCTTALPGSSKRRRKEET-----TGKNVK--- 255

  Fly   236 NQRRNSKPFELDAQGLVPLPAKTCFYCTRSCKRAPLISCDYCPLYFHQDCLDPPLTALPAGLWMC 300
                 ....|||..||||||.|.||.|.|||:.||||.||||||.||.|||:|||||:|.|.|||
Human   256 -----KTQHELDHNGLVPLPVKVCFTCNRSCRVAPLIQCDYCPLLFHMDCLEPPLTAMPLGRWMC 315

  Fly   301 PNHAENFI--DANMTNSISATERVRLWNRFHQPLDHENVKLEFFRRVNTRNPPFRTKRNLRARAH 363
            |||.|:.:  ..|||.|    .|.::::||...:....||::|..|::.::||.|.......|..
Human   316 PNHIEHVVLNQKNMTLS----NRCQVFDRFQDTVSQHVVKVDFLNRIHKKHPPNRRVLQSVKRRS 376

  Fly   364 IEVPAIVRYHYDHPPPL---------------LPSMRQTLRYDRVKRRNNLPTEVEE----ISRE 409
            ::||..::..|..||||               :|...|.    .:....:|.|:.|:    .|..
Human   377 LKVPDAIKSQYQFPPPLIAPAAIRDGELICNGIPEESQM----HLLNSEHLATQAEQQEWLCSVV 437

  Fly   410 SVTESLLKDLEALRTAHAKFREIQREFGTLETAIDGDSD-------SDPSPEEKRTETNTPADKV 467
            ::..|:||.|.| :...:.:...|.|...::..|..||.       :|.:|    |.::.|....
Human   438 ALQCSILKHLSA-KQMPSHWDSEQTEKADIKPVIVTDSSVTTSLQTADKTP----TPSHYPLSCP 497

  Fly   468 NGEVDTEN----------PNTE-----SNAQASEQPSVVKVESKTSLEVEA------SFEEDEED 511
            :| :.|:|          |..|     |.|:.|::..........:.||:|      |...|..|
Human   498 SG-ISTQNSLSCSPPHQSPALEDIGCSSCAEKSKKTPCGTANGPVNTEVKANGPHLYSSPTDSTD 561

  Fly   512 SKKSTGIIDADLLHLDVDIIKKLAHQR----------LQQLVEEHPEIVTQYKNRTAARRLRQ-- 564
            .::..|....         :..|:|::          ...|......|:.:.:|.|......|
Human   562 PRRLPGANTP---------LPGLSHRQGWPRPLTPPAAGGLQNHTVGIIVKTENATGPSSCPQRS 617

  Fly   565 --------------LASVDGTHVAGETAALQGQLAP---------EDMNRFSLLFTSETS--SIL 604
                          .||::.|... :...:|.|:.|         ...|...:|...:.:  .||
Human   618 LVPVPSLPPSIPSSCASIENTSTL-QRKTVQSQIGPPLTDSRPLGSPPNATRVLTPPQAAGDGIL 681

  Fly   605 A----QKNGNAADEDPATALHPALATAAAIAAADAAAESYAPRARSDTEKAY-ELASRLELKLLQ 664
            |    |:..:.|...........|:..:|:......|.|.|....:::.:|: ::...:|:.:|.
Human   682 ATTANQRFSSPAPSSDGKVSPGTLSIGSALTVPSFPANSTAMVDLTNSLRAFMDVNGEIEINMLD 746

  Fly   665 CK-------------------------------------------VQARAVITPLGDMLEDSRWF 686
            .|                                           ||||||..||
Human   747 EKLIKFLALQRIHQLFPSRVQPSPGSVGTHQLASGGHHIEVQRKEVQARAVFYPL---------- 801

  Fly   687 SSLGLDHSIFMRYRTLYIGYGGHYSPSTTLAQTETVDLSAIGYCCRISPQHAIIFYDEFSKSYEL 751
              |||..::.|.|||||||.|....          |.|:..|:|..:|.:||.|||||.:|.|||
Human   802 --LGLGGAVNMCYRTLYIGTGADMD----------VCLTNYGHCNYVSGKHACIFYDENTKHYEL 854

  Fly   752 INYSEFGTEVNGQLYACDVTERMTTHAGKPMRPDDAELKKRVDEMLDKRRNINRQFETKK----I 812
            :||||.||.|:..||:||.:|:      .|..|..:.:.| |..::.:||:..:..|..:    :
Human   855 LNYSEHGTTVDNVLYSCDFSEK------TPPTPPSSIVAK-VQSVIRRRRHQKQDEEPSEEAAMM 912

  Fly   813 DKERLAPIVKPACRCMNAGPVPMVDGA---WEGSAVLAHGSLLRFGCLSFVFVV 863
            ..:...|..:| |.| .|....::.|:   |||:|:|.|||.::.|||.|||.:
Human   913 SSQAQGPQRRP-CNC-KASSSSLIGGSGAGWEGTALLHHGSYIKLGCLQFVFSI 964

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG3815	NP_572311.1	PHD1_PHF12	55..99	CDD:277008	29/43 (67%)
		BAH	75..198	CDD:470629	45/153 (29%)
		PHF12_MRG_bd	175..211	CDD:465250	14/48 (29%)
		PHD2_PHF12_Rco1	259..303	CDD:277009	32/43 (74%)
		FHA	667..861	CDD:469597	73/200 (37%)
PHF12	NP_001028733.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	28..59		12/33 (36%)
		PHD1_PHF12	58..102	CDD:277008	29/43 (67%)
		Interaction with SIN3A. /evidence=ECO:0000269|PubMed:11390640	102..273		50/189 (26%)
		PBR	105..128		6/27 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	113..142		7/33 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	154..187		7/32 (22%)
		SIN3 interacting domain 1. /evidence=ECO:0000269|PubMed:37137925	202..241		15/38 (39%)
		PHF12_MRG_bd	203..241	CDD:465250	15/37 (41%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	234..257		7/35 (20%)
		PHD2_PHF12_Rco1	273..318	CDD:277009	32/44 (73%)
		Interaction with SIN3A. /evidence=ECO:0000269|PubMed:11390640	300..704		93/427 (22%)
		SIN3 interacting domain 2. /evidence=ECO:0000269|PubMed:37137925	328..364		11/39 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	530..580		9/58 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	641..673		5/32 (16%)
		FHA_PHF12	790..966	CDD:438755	75/206 (36%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	895..923		4/27 (15%)