DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3815 and phf12a

DIOPT Version :9

Sequence 1:	NP_572311.1	Gene:	CG3815 / 31571	FlyBaseID:	FBgn0029861	Length:	878	Species:	Drosophila melanogaster
Sequence 2:	XP_001919955.4	Gene:	phf12a / 562152	ZFINID:	ZDB-GENE-030131-3876	Length:	941	Species:	Danio rerio

Alignment Length:	981	Identity:	283/981 - (28%)
Similarity:	421/981 - (42%)	Gaps:	217/981 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 DPNASLSIMEQIKQLIRPPPNED----EKMMQRSTNTKHPYYRRPGRGHNHDYCDACEEGGNLLC 67
            |.:.|..:||:|:.|:.||.:||    .:...|||       ||.||..|||.||:|.|||:|||
Zfish    13 DLDTSGGLMEKIQTLLAPPKSEDGEKKNRKPDRST-------RRSGRATNHDICDSCREGGDLLC 70

  Fly    68 CDRCPSSFHLQCHDPPLSEEDIPSGQWLCHSC--------------------RMSKLSQPPASSS 112
            ||.||::|||||.:||||.|.:|||.|:||.|                    ::.|.:.|||...
Zfish    71 CDHCPAAFHLQCCNPPLSREMLPSGDWMCHRCTVRKKKREQKKEQINGLLERQLGKQTPPPAPEQ 135

  Fly   113 KASSVERVPSAGSGSRANTPSSGDLESIPLKIRNLRKR---------SN---------SERNSTE 159
            ...::...||.|:|...       |.:...::|.|.:|         ||         ||:|.||
Zfish   136 DCGTLRLDPSVGTGGTG-------LRAAVAQVRLLERRHSSRPATPNSNTSSADTPTPSEQNDTE 193

  Fly   160 KLLAKMPMSIQRALDPNKKPT------PLDDVIRAATMMNPQQFSLPPELELHTQFPGNGKVQPV 218
            :.|..:....|.: :|....|      |.|.:|.||...||.||.||.:|...|..||..|
Zfish   194 EDLLDVEDETQGS-EPELLNTTTTLKRPFDLLIAAAMQRNPTQFQLPNDLTCTTALPGTSK---- 253

  Fly   219 QQTHPPSGNGGNRRCAGNQRRNSKP-FELDAQGLVPLPAKTCFYCTRSCKRAPLISCDYCPLYFH 282
                      ..|:...:.:...:| .|||:.||||||.|.|:.|:|||:.||||.||:|||.||
Zfish   254 ----------RRRKDELSSKSVKRPQHELDSCGLVPLPVKVCYTCSRSCRLAPLIQCDFCPLLFH 308

  Fly   283 QDCLDPPLTALPAGLWMCPNHAENFIDANMTNSISATERVRLWNRFHQPLDHENVKLEFFRRVNT 347
            .|||||||||.|.|.||||||.:|.| .|. .|::.:.|.:|:::|...:....|||:|.:|::.
Zfish   309 MDCLDPPLTAFPTGRWMCPNHIQNLI-LNQ-RSLTISNRCQLFDQFQDCISQHAVKLDFLQRIHR 371

  Fly   348 RNPPFRTKRNLRARAHIEVPAIVRYHYDHPPPLLPSMRQTLRYDRVKRRNNLPTEVEE------I 406
            ::||.:...:.|::..::||..::..|.:||.|:.|.       .|:....:.|.:.|      :
Zfish   372 QHPPIQRSTHARSKKTLKVPDAIKSQYQNPPTLMASA-------GVREGELICTGLPEASVPQHL 429

  Fly   407 SRESVTESLLKDLEALR----------------TAHAKFREIQREFGTLETAIDGDSDSDPS-PE 454
            :.|......|||:.:|:                :.|.:..:::........|..|..:|.|. |.
Zfish   430 ASEDEQHQWLKDIISLQCSIMRHLRNRQTSHWDSEHTEKTDLKLRDSCQSAASQGSQNSSPKVPC 494

  Fly   455 EKRTE--------TNTPADKVNGEVDTENPNTESNAQASEQPSVVKVESKTSLEVEASFEEDEED 511
            ...||        ||.|.|:......|::|....|..|..:...:.:.|..:.....:..:.|:.
Zfish   495 SSCTEGLCQNCKTTNGPVDQSVQSNGTQDPVRTQNKSADREKPCLPMPSPLNHANSGAIIKGEDA 559

  Fly   512 SKKSTGIIDADLLHLDVDIIKKLAHQRLQQLVEEHPEIVTQYKNRT-----AARRLRQLASVDGT 571
            |.|.....|.            |...|    |:..|........:|     ||.::.......|.
Zfish   560 SLKPRSGTDV------------LPPAR----VKSEPRTQPCDHAKTPPASDAAAKVSDSTVCTGA 608

  Fly   572 HV-----AGETAALQGQLAPEDM--NRFSL--------LFTSETSSILAQKNGNAAD------ED 615
            |.     ....|...||.:|...  .:.||        ..:|.|...:::.:|...|      |.
Zfish   609 HAVKPQKVTSDAGSNGQRSPSSSCGGKSSLDSVMAGSGDISSCTEPNMSELSGRIKDIMQGGGEV 673

  Fly   616 PATALHPALATAAAIAAADAAAESYAPRARSDTEKAYELASRLELKLLQCKVQARAVITPLGDML 680
            ...||........|........:|.:...:|.:..:...|.|...:....:|||||.
Zfish   674 ELNALDEKFIKLLAWQRIQQLFDSKSSPVQSSSPLSVSPAHRKHGEAQNREVQARAS-------- 730

  Fly   681 EDSRWFSSLGLDHSIFMRYRTLYIGYGGHYSPSTTLAQTETVDLSAIGYCCRISPQHAIIFYDEF 745
                 |.|:. .:::.|.||:|:||.|....          |.|:..|:|..:|.:||.|||||.
Zfish   731 -----FCSVS-GNAVNMCYRSLHIGTGADMD----------VCLTNYGHCNYVSGKHACIFYDEN 779

  Fly   746 SKSYELINYSEFGTEVNGQLYACDVTERMTTHAGKPMRPDDAELKKRVDEMLDKRRNINRQFETK 810
            :|.|||:||||.||.|:..||:||.:|:|:              :.....:|.|.:||.|:...|
Zfish   780 TKQYELLNYSEHGTTVDNILYSCDFSEKMS--------------QSPSSNLLTKVQNIIRRCRKK 830

  Fly   811 -KIDKERLAPIVKPA--------------CRCMNAGPVPMVDGA---WEGSAVLAHGSLLRFGCL 857
             :.|.....|..|..              |.|.|:|. .|:.|:   |||:|:|.|||.::.|||
Zfish   831 EQEDSLNSVPSAKEVTHMSCQSQDASVTPCNCKNSGS-RMIGGSGAGWEGTALLHHGSHVKLGCL 894

  Fly   858 SFVFVV 863
            .|:|.:
Zfish   895 QFIFSI 900

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3815	NP_572311.1	PHD1_PHF12	55..99	CDD:277008	29/43 (67%)
		BAH	75..198	CDD:295389	48/166 (29%)
		PHF12_MRG_bd	175..211	CDD:293342	15/41 (37%)
		PHD2_PHF12_Rco1	259..303	CDD:277009	31/43 (72%)
		FHA	<732..>765	CDD:238017	19/32 (59%)
phf12a	XP_001919955.4	PHD1_PHF12	59..102	CDD:277008	29/42 (69%)
		BAH	78..>140	CDD:295389	21/61 (34%)
		PHF12_MRG_bd	214..252	CDD:293342	15/37 (41%)
		PHD2_PHF12_Rco1	284..329	CDD:277009	31/44 (70%)
		FHA	<744..>797	CDD:238017	28/62 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586355
Domainoid	1	1.000	122	1.000	Domainoid score	I5585
eggNOG	1	0.900	-	-		E1_KOG4299
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	337	1.000	Inparanoid score	I2356
OMA	1	1.010	-	-		QHG49783
OrthoDB	1	1.010	-	-		D1203363at2759
OrthoFinder	1	1.000	-	-		FOG0003315
OrthoInspector	1	1.000	-	-		otm25870
orthoMCL	1	0.900	-	-		OOG6_106762
Panther	1	1.100	-	-	O	PTHR46309
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1691
SonicParanoid	1	1.000	-	-		X2689
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800