DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3815 and CG1815

DIOPT Version :9

Sequence 1:	NP_572311.1	Gene:	CG3815 / 31571	FlyBaseID:	FBgn0029861	Length:	878	Species:	Drosophila melanogaster
Sequence 2:	NP_651881.2	Gene:	CG1815 / 43730	FlyBaseID:	FBgn0039863	Length:	1664	Species:	Drosophila melanogaster

Alignment Length:	741	Identity:	136/741 - (18%)
Similarity:	231/741 - (31%)	Gaps:	242/741 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 RSTNTKHP----------YYRRPGRGHNHDYCDACEEGGNLLCCDRCPSSFHLQCHDPPLSEEDI 89
            ::|..|.|          .|..|.......:|..|...|.|:.|.:|..|||..|..|..::.|
  Fly   315 KTTTAKTPEEEAAERLALIYEEPPTPGWDPFCWKCRGCGKLMPCSKCLRSFHSYCVRPATTKFD- 378

  Fly    90 PSGQWLCHSC----------RMSKLSQPPASSSKASSVERVPSAGSGSRANTPSSGDLESIPLKI 144
              ..|.|..|          |.:.:|....|...:.:::|:.......:..:|    ||..||
  Fly   379 --SSWKCPECQVIEAAPKRLRRNGVSVDLLSQLLSFALDRMKHVRGAHKLRSP----LEVFPL-- 435

  Fly   145 RNLRKRSNSERNSTEKLLAKMPMSIQRALDPNKKPTPLDDVIRAATMMNPQQFSLPPELELHTQF 209
                         |.|.....|:|.:          .|...||.....:..:|....:...|...
  Fly   436 -------------TYKKFFVNPVSFE----------SLAQCIRNGAYQSTDEFLSEVKWIQHNAL 477

  Fly   210 ---PGNGKVQPVQQTHPPSGNGGNRRCAGNQRRNSKPFELDAQGLVPLPAKTCFYCTRSCKRAPL 271
               .|:.||:...:...       :.|  .|..|    |:|          ||..|        .
  Fly   478 ILDAGDAKVEQASKAVV-------KVC--RQEAN----EID----------TCPEC--------Y 511

  Fly   272 ISCDYCPLYFHQDCLDPPLTALPAGLWMCPNHAENFIDANMTNSISATERVRLWNRFHQPLDHEN 336
            ::.:....:|.:.|..|.|.     ||........:....|.:|.|....||.:.:.    |...
  Fly   512 LNANSSDEWFVKVCRHPHLL-----LWAKLKGFPYWPAKAMGSSNSTLVNVRFFGKH----DRAF 567

  Fly   337 VKLEFFRRVNTRNPPFRTKRNLRARAHIEVPAIVRYHYDHPPPLLPSMRQTLRYDRVKRR----N 397
            |.::.....:.:||..:|.|. .||...|....|..|.||                :||:    |
  Fly   568 VPVKDCFLYSAQNPNTQTSRR-SARDLAECIREVEIHIDH----------------IKRKIGAFN 615

  Fly   398 NLP--TEVEEISRESVTESLL--------KDLEAL----------RTAHAKFREIQREFGTLETA 442
            ..|  |..:.:..:...|.::        ::||..          :||..|...:::   |..|.
  Fly   616 YAPYRTPYDPLEEQQQLEQMMPGVYAAIDRELEPANKTPLQFLIRKTADDKLSIVKK---TKATE 677

  Fly   443 IDGDSDSDPSPEEKRTETNTPADKVNGEVDTENPNTESN-----AQASEQPS------VVKVESK 496
            ...:||..|||.:|.:|.:..:  |.|...:::.|.:||     :::.|..:      ::|.:|.
  Fly   678 SGNESDQSPSPTKKLSEVDVVS--VTGSGCSDHSNVKSNNYEVISRSGESLTDSRCKVLLKRKSL 740

  Fly   497 TSLEVEASFEEDEEDS-KKSTGIIDADLLHLDVDIIKKLAHQRLQQLVEEHPEIVTQYKNRTAAR 560
            .:..|..|.|..|..: |:...:.||.......:..:|..|.|.|.
  Fly   741 AAKIVAESVETSEAVAPKRKHSLSDASFTSESSEHKRKSKHARKQH------------------- 786

  Fly   561 RLRQLASVDGTHVAGETAALQGQLAPEDMNRFSLLFTSETSSILAQKNGNAADED--------PA 617
                    |......|.|...||..|:             |..::::|.|..||:        ..
  Fly   787 --------DNQDNQIEEAEKTGQEPPK-------------SPTISKQNENLRDEENVIENAANDT 830

  Fly   618 TALHPALATAAAI---------------------AAADAAA-------------------ESYAP 642
            ::..|..|:..::                     .|.|.||                   |:..|
  Fly   831 SSASPVSASVVSVVELVRRRQGVTITKIPREQQQTAEDTAAVPIPLPTAPPPKQNIPKGNEAANP 895

  Fly   643 RARSDTEKAYELASRLELKLLQCKVQ 668
            : :||.|:..|...:..:..::.|.:
  Fly   896 K-QSDVERQQEQLIKKVIPFIEIKTE 920

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3815	NP_572311.1	PHD1_PHF12	55..99	CDD:277008	14/43 (33%)
		BAH	75..198	CDD:295389	24/132 (18%)
		PHF12_MRG_bd	175..211	CDD:293342	5/38 (13%)
		PHD2_PHF12_Rco1	259..303	CDD:277009	8/43 (19%)
		FHA	<732..>765	CDD:238017
CG1815	NP_651881.2	PHD_PRKCBP1	345..386	CDD:277013	14/43 (33%)
		Bromo_RACK7	403..501	CDD:99940	21/135 (16%)
		BS69_related	520..603	CDD:99902	21/92 (23%)
		zf-MYND	1399..1433	CDD:280009
		Med3	<1428..1664	CDD:288447
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45450446
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930