DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3815 and Aire

DIOPT Version :9

Sequence 1:	NP_572311.1	Gene:	CG3815 / 31571	FlyBaseID:	FBgn0029861	Length:	878	Species:	Drosophila melanogaster
Sequence 2:	XP_006256309.1	Gene:	Aire / 294328	RGDID:	1311139	Length:	551	Species:	Rattus norvegicus

Alignment Length:	320	Identity:	75/320 - (23%)
Similarity:	105/320 - (32%)	Gaps:	110/320 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 QDPNASLSIM----EQIKQLIRP-------PPNEDEKMMQRSTNTKHPYYRRPGRGH--NHDYCD 57
            :||:.:|...    ..:|.:||.       |..:::|:.|:......|......:.|  |.|.|.
  Rat   238 EDPSGNLKNKTRGGSSLKPVIRGKGTQVTIPGRDEQKVSQQCGVPPLPPLPNEPQVHQKNEDECA 302

  Fly    58 ACEEGGNLLCCDRCPSSFHLQCHDPPLSEEDIPSGQWLCHSCRMSKLSQPPASSSKASSVERVPS 122
            .|.:||.|:|||.||.:|||.|..|||.|  ||||.|.|..|...::.|..:...::..:|  ||
  Rat   303 VCHDGGELICCDGCPRAFHLACLSPPLQE--IPSGLWRCSCCLQGRIQQNLSQPEESRPLE--PS 363

  Fly   123 AGSGSRANTPSSGDLESIPLKIRNLRKRSNSERNSTEKLLAKMPMSIQRALDPNKKPTPLDDVIR 187
                  |.||.          :..||..|...|..:.:|                 |...|..:.
  Rat   364 ------AETPI----------LLGLRSASEKTRVLSREL-----------------PAGSDAAVT 395

  Fly   188 AATMMNPQQFSLPPELELHTQFPGNGKVQPVQQTHPPSGNGGNRRCAGNQRRNSKPFELDAQGLV 252
            .|.::.|.  |..|.||                   ||                        .|.
  Rat   396 YANLLAPP--STAPVLE-------------------PS------------------------ALC 415

  Fly   253 PLP------------AKTCFYCTRSCKRAPLISCDYCPLYFHQDCLDPPLTALPAGLWMC 300
            |||            :..|..|..|   ..::.|.:|...||..|..|.....|.....|
  Rat   416 PLPSAGAEGQPGPTLSARCGVCGDS---TDVLRCAHCAAAFHWRCHFPMAAVRPGTNLRC 472

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3815	NP_572311.1	PHD1_PHF12	55..99	CDD:277008	24/43 (56%)
		BAH	75..198	CDD:295389	31/122 (25%)
		PHF12_MRG_bd	175..211	CDD:293342	8/35 (23%)
		PHD2_PHF12_Rco1	259..303	CDD:277009	11/42 (26%)
		FHA	<732..>765	CDD:238017
Aire	XP_006256309.1	Sp100	17..103	CDD:281203
		SAND	198..264	CDD:295351	6/25 (24%)
		PHD1_AIRE	300..342	CDD:277014	24/43 (56%)
		PHD2_AIRE	433..475	CDD:277015	11/43 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1203363at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010