DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mldr and Prorp

DIOPT Version :9

Sequence 1:	NP_001245549.1	Gene:	mldr / 31568	FlyBaseID:	FBgn0029858	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_079649.1	Gene:	Prorp / 66132	MGIID:	1913382	Length:	584	Species:	Mus musculus

Alignment Length:	548	Identity:	149/548 - (27%)
Similarity:	251/548 - (45%)	Gaps:	53/548 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 NLLPIAGHAH-------------PRWLAS-QHKRRPQPGSLPADRLDQL--RSDLFERRHELSGA 57
            |||......|             |.:.|: ..|:|...|:.|.::...|  ||.:......|:.|
Mouse    58 NLLDTKARTHRKGNDNNGQVSSDPHYFAAGAAKKRSHIGANPQNQGHALPVRSSVQLPTKPLNSA 122

  Fly    58 EWTEVRRSLVDGYKHINGHNVDAVILGVCSAPNQLSLAKSYVEFLRSRGSKPNAATLGRLLRV-- 120
            ||.:::... .|........:..:....||    :.:|||.:.::.::    |...:|..|.|
Mouse   123 EWDKLKEDF-KGKASFEDFIISQMARNCCS----VDVAKSLLAWVAAK----NNGIVGYNLLVKY 178

  Fly   121 -YNAAYHERPLSEAEQSEILQICRSLQAEHETLDASSCENVIHGLVATSGDDWQRGLPLLEMMKV 184
             |...:|:      :.||::.:...::|::::|::.....:|.||:  ..|.|:..|.|||.:|.
Mouse   179 LYLCVFHK------QTSEVIDVYEIMKAKYKSLESGGYTLLIRGLI--HSDRWRESLLLLEDIKK 235

  Fly   185 TSTPSVAAYSALAEKAFSVATPEQELAWRLLEEMATARKPPKCEVYLALLN--RLANETAQLPAQ 247
            ...||...|....:.|  :...:...||.|.:|:......|..|...|..:  :..|:.......
Mouse   236 VMVPSKKNYGDCIQGA--LLHQDVNTAWNLYQELIGHNLIPPLETLKAFFDYGKDINDDHYSDKL 298

  Fly   248 LSLLLQFLERHEILVSQRVAIRLQELSSQVP-QLLHTRTTHLGGLGKCQSCQQHLQPVAISDEEF 311
            |.:|| :|..:::...:..|..::.....:| :....:.|.:...|:|..|.:.::|:.:|.||:
Mouse   299 LDILL-YLRNNQLYPGESFAHSIKTWFESIPGRQWKGQFTTIQKSGQCSGCGRTIEPIHLSPEEY 362

  Fly   312 RQLSECFLERVLIRRDVFQRSTPEEVARFKKFVEKTAPYDCVIDGLNVAYSTGTKKTPQQLAKLV 376
            ..|.|..:..|:...|.::::||:|:.||:.||....|:|.||||||||......:..|.|
Mouse   363 EFLKEKIMRDVIDGGDQYKKTTPQELKRFESFVNSCPPFDIVIDGLNVAKMFPKGRESQNL---- 423

  Fly   377 ATVVRHFREQDKRVLVLGREHM----RNWSKQAMHYVHCNASLFLTSNLSHDDPFLLYATLRSGQ 437
            ..||....:|:.::|||||:||    ..|.|:.|..|...|..|...|:|.||||||||||.||.
Mouse   424 LGVVSQLAQQNLQLLVLGRKHMLRPSSQWRKEEMEQVRKQAHCFFADNISEDDPFLLYATLNSGN 488

  Fly   438 ETDFFSRDLMRSHAFHL-GTELKPIFRRWQQEHQFSLVTQTQTGQIIVKEPVRHRLCAHQVADTW 501
            ...|.::||:|.|...| ....:.:|.:|||.||.:::...|..::..:..:.:.....:..|:|
Mouse   489 HCKFITKDLLRDHKACLPDARTQRLFFKWQQGHQLAIMKGFQKSKLTFQHILSYDTVVQRTGDSW 553

  Fly   502 HVPYCAQYTPHPTDSFEVPANWLCIQMK 529
            |:||.......  .|.|||..|||:|.|
Mouse   554 HIPYDEDLVQR--SSCEVPTKWLCLQRK 579

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mldr	NP_001245549.1	PRORP	288..525	CDD:293558	83/241 (34%)
Prorp	NP_079649.1	PPR repeat	171..201	CDD:276811	7/35 (20%)
		PPR repeat	207..236	CDD:276811	10/30 (33%)
		PPR repeat	241..268	CDD:276811	6/28 (21%)
		PRORP	339..575	CDD:293558	83/241 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831546
Domainoid	1	1.000	158	1.000	Domainoid score	I4133
eggNOG	1	0.900	-	-		E1_28J82
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H45935
Inparanoid	1	1.050	193	1.000	Inparanoid score	I3842
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47571
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007821
OrthoInspector	1	1.000	-	-		oto95425
orthoMCL	1	0.900	-	-		OOG6_107723
Panther	1	1.100	-	-	LDO	PTHR13547
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5839
SonicParanoid	1	1.000	-	-		X5770
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.790