DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mldr and prorp

DIOPT Version :9

Sequence 1:	NP_001245549.1	Gene:	mldr / 31568	FlyBaseID:	FBgn0029858	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	XP_683289.3	Gene:	prorp / 555630	ZFINID:	ZDB-GENE-100618-4	Length:	578	Species:	Danio rerio

Alignment Length:	541	Identity:	144/541 - (26%)
Similarity:	244/541 - (45%)	Gaps:	74/541 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 AGHAHPRWLASQHKR-------------RPQPGSLPADRLDQLRSDLFERRHELSGAEWTEVRR- 64
            ||.|..|....:||.             |..|..:..||             .|:.:|||.:::
Zfish    81 AGAARKRAEFLKHKSGLDTENDDTPVRVRDSPNMVLPDR-------------PLTPSEWTNLKKD 132

  Fly    65 -SLVDGYKHINGHNVDAVILGVCSAPNQLSLAKSYVEF-LRSRGSKPNAATLGRLLRVYNAAYHE 127
             |..:.::.:...|       :..|...:::|||.:.: ::.:|:......|..|.....|.:|
Zfish   133 FSRPELFEKVMMEN-------LVRANVDVNIAKSLLSYVVQDKGTLSYEILLRYLTICVRAGHH- 189

  Fly   128 RPLSEAEQSEILQICRSLQAEHETLDASSCENVIHGLVATSGDDWQRGLPLLEMMKVTSTPSVAA 192
                    ||:......:::..::||..:....|.|...|  |.|:..:.:|:.||....||...
Zfish   190 --------SEVFDAYDIMRSCFKSLDLGASALFIKGFSQT--DRWKEAISMLQDMKKALLPSPRN 244

  Fly   193 YSALAEKAFSVATPEQELAWRLLEEMATARKPPKCEVYLAL----LNRLANETAQLPAQLSLLLQ 253
            |..:.  |.:|...:.|.:|:|.:|:......|..:.:..|    :.:..:|.     :|..:|.
Zfish   245 YGDVI--AGAVLHGDSETSWKLYDELLELGLVPGQDTWQCLFQSGITQRGHED-----KLFDVLS 302

  Fly   254 FLERHEILVSQRVAIRLQELSSQVP-QLLHTRTTHLGGLGKCQSCQQHLQPVAISDEEFRQLSEC 317
            ::..::|...:.:...::.....:| |....:.:.:...|.|::|:..|:.:.:::.|:.||...
Zfish   303 YMRDNQIYPEKPLMETIKAWFESLPDQKWRGKFSSVTPSGDCRNCKALLESIQLTEVEYAQLKHN 367

  Fly   318 FLERVLIRRDVFQRSTPEEVARFKKFVEKTAPYDCVIDGLNVAYSTGTKKTPQ--QLAKLVATVV 380
            .:|:|:...|||.:|.|||:..||.||::..|:|.||||||||     |..|.  |...|:| ||
Zfish   368 VMEKVIEGGDVFNKSNPEELKSFKSFVKQRPPFDIVIDGLNVA-----KMLPHAAQSETLLA-VV 426

  Fly   381 RHFREQDKRVLVLGREHM----RNWSKQAMHYVHCNASLFLTSNLSHDDPFLLYATLRSGQETDF 441
            ....:|...:|||||:||    |||.:|.|..:...|..|.|.::|.|||:||||.|.||....|
Zfish   427 SELEQQSLNILVLGRKHMLRHSRNWDRQNMSLIKQKAHCFFTEDISEDDPYLLYAALNSGVHCKF 491

  Fly   442 FSRDLMRSHAFHL-GTELKPIFRRWQQEHQFSLVTQTQTGQIIVKEPVRHRLCAHQVADTWHVPY 505
            .||||||.|...| .:..:.:|.:||:.||..:...|...::..:..:.:.........:||:||
Zfish   492 LSRDLMRDHKACLPDSATRCLFFKWQRGHQLVISHYTPGKRVRFERILSYDTIIQTNGSSWHIPY 556

  Fly   506 CAQYTPHPTDSFEVPANWLCI 526
              ........|:|||..|||:
Zfish   557 --DQKAEDRASYEVPQKWLCL 575

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mldr	NP_001245549.1	PRORP	288..525	CDD:293558	88/243 (36%)
prorp	XP_683289.3	PPR repeat	172..202	CDD:276811	6/38 (16%)
		PPR repeat	215..237	CDD:276811	8/23 (35%)
		PPR repeat	242..271	CDD:276811	7/30 (23%)
		PPR repeat	277..307	CDD:276811	4/34 (12%)
		PRORP	338..574	CDD:293558	88/243 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574588
Domainoid	1	1.000	156	1.000	Domainoid score	I4152
eggNOG	1	0.900	-	-		E1_28J82
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H45935
Inparanoid	1	1.050	173	1.000	Inparanoid score	I4070
OMA	1	1.010	-	-		QHG47571
OrthoDB	1	1.010	-	-		D1247650at2759
OrthoFinder	1	1.000	-	-		FOG0007821
OrthoInspector	1	1.000	-	-		oto39707
orthoMCL	1	0.900	-	-		OOG6_107723
Panther	1	1.100	-	-	LDO	PTHR13547
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5770
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	15	14.810