DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rpt4 and RPT4

DIOPT Version :9

Sequence 1:	NP_572308.3	Gene:	Rpt4 / 31567	FlyBaseID:	FBgn0028685	Length:	397	Species:	Drosophila melanogaster
Sequence 2:	NP_014902.3	Gene:	RPT4 / 854433	SGDID:	S000005785	Length:	437	Species:	Saccharomyces cerevisiae

Alignment Length:	381	Identity:	267/381 - (70%)
Similarity:	330/381 - (86%)	Gaps:	0/381 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 KALSEYRKKLLEHKEIEGRLKEKREEIKDLTKLYDKSENDLKALQSVGQIVGEVLKQLTEDKFIV 79
            |||:::::|||||:..:.:||::|:.|:||.|||||:|||:|||||:||::|||:|:|:|:|:||
Yeast    55 KALNQFKRKLLEHRRYDDQLKQRRQNIRDLEKLYDKTENDIKALQSIGQLIGEVMKELSEEKYIV 119

  Fly    80 KATNGPRYVVGCRRQLDKAKLKSGTRVALDMTTLTIMRYLPREVDPLVYNMSHEDPGDVTYSAIG 144
            ||::||||:||.|..:|::|||.|.||.||:|||||||.||||.|||||||:..:.|::|:..||
Yeast   120 KASSGPRYIVGVRNSVDRSKLKKGVRVTLDITTLTIMRILPRETDPLVYNMTSFEQGEITFDGIG 184

  Fly   145 GLTDQIRELREVIELPLLNPELFLRVGITPPKGCLLYGPPGTGKTLLARAVASQLDANFLKVVSS 209
            |||:|||||||||||||.|||:|.||||.||||.||||||||||||||:|||:.:.|||:...:|
Yeast   185 GLTEQIRELREVIELPLKNPEIFQRVGIKPPKGVLLYGPPGTGKTLLAKAVAATIGANFIFSPAS 249

  Fly   210 AIVDKYIGESARLIREMFNYARDHQPCIIFMDEIDAIGGRRFSEGTSADREIQRTLMELLNQMDG 274
            .|||||||||||:|||||.||::|:||||||||:||||||||||||||||||||||||||.||||
Yeast   250 GIVDKYIGESARIIREMFAYAKEHEPCIIFMDEVDAIGGRRFSEGTSADREIQRTLMELLTQMDG 314

  Fly   275 FDSLGQVKMIMATNRPDTLDPALLRPGRLDRKIEIPLPNEQARLEILKIHALKIAKHGEIDYEAI 339
            ||:|||.|:|||||||||||||||||||||||:|||||||..||||.|||..|:.|.||.|:||.
Yeast   315 FDNLGQTKIIMATNRPDTLDPALLRPGRLDRKVEIPLPNEAGRLEIFKIHTAKVKKTGEFDFEAA 379

  Fly   340 VKLSDNFNGADLRNVCTEAGLFAIRAEREYVIQEDFMKAVRKVSDNKKLESKLDYK 395
            ||:||.|||||:||..||||.||||.:|:::..:|.|||||||::.||||..::|:
Yeast   380 VKMSDGFNGADIRNCATEAGFFAIRDDRDHINPDDLMKAVRKVAEVKKLEGTIEYQ 435

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rpt4	NP_572308.3	RPT1	13..395	CDD:224143	266/379 (70%)
Rpt4	NP_572308.3	AAA	179..311	CDD:278434	109/131 (83%)
RPT4	NP_014902.3	RPT1	43..435	CDD:224143	266/379 (70%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343114
Domainoid	1	1.000	229	1.000	Domainoid score	I416
eggNOG	1	0.900	-	-		E1_COG1222
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H100630
Inparanoid	1	1.050	558	1.000	Inparanoid score	I162
Isobase	1	0.950	-	0	Normalized mean entropy	S249
OMA	1	1.010	-	-		QHG53508
OrthoFinder	1	1.000	-	-		FOG0003819
OrthoInspector	1	1.000	-	-		otm46592
orthoMCL	1	0.900	-	-		OOG6_101751
Panther	1	1.100	-	-	LDO	PTHR23073
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R997
SonicParanoid	1	1.000	-	-		X2663
TreeFam	1	0.960	-	-
	16	15.740