DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment wuho and TRM82

DIOPT Version :9

Sequence 1:	NP_572307.1	Gene:	wuho / 31566	FlyBaseID:	FBgn0029857	Length:	424	Species:	Drosophila melanogaster
Sequence 2:	NP_010449.1	Gene:	TRM82 / 851743	SGDID:	S000002572	Length:	444	Species:	Saccharomyces cerevisiae

Alignment Length:	363	Identity:	83/363 - (22%)
Similarity:	147/363 - (40%)	Gaps:	66/363 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 STATAASGQAPGGKEQQLANQPEEGG----TSAS--ASGLGCATSTS-VQNVAYSPD-GQLLAVT 116
            :||....||:...:.:....:..:|.    |:|.  :.|||.....| ::|:..:.| .:|:|..
Yeast    57 TTAKEQQGQSSENENENKKLKSNKGDSIKRTAAKVPSPGLGAPPIYSYIRNLRLTSDESRLIACA 121

  Fly   117 TSGKQKALLLYRSRPENARLLSARP---LARASSALRFCSDSSSILVTDKTGDCYQYDCVEV--- 175
            .|  .|:||::.....:..:|..|.   .::..:|:....|.:::::.||.||.|..|...:
Yeast   122 DS--DKSLLVFDVDKTSKNVLKLRKRFCFSKRPNAISIAEDDTTVIIADKFGDVYSIDINSIPEE 184

  Fly   176 ---EAPPRLLLGHLSVVYD---ILWSEDQQHIITCDRDDKIRVTNYPATFDIHSYCLGHREFVSG 234
               :.|   :|||:|::.|   |..|:..|.|||.|||:.|::::||..|.:..:..||:.|||.
Yeast   185 KFTQEP---ILGHVSMLTDVHLIKDSDGHQFIITSDRDEHIKISHYPQCFIVDKWLFGHKHFVSS 246

  Fly   235 LALLTEQHIASASGDKTLRVWNYIQGKELL--------------QHELPA-------PAVRLLVR 278
            :....:..:.||.||..:..|::..||.|.              ||..|.       ..:...|.
Yeast   247 ICCGKDYLLLSAGGDDKIFAWDWKTGKNLSTFDYNSLIKPYLNDQHLAPPRFQNENNDIIEFAVS 311

  Fly   279 QLEPEKVFQAAVLFYEHVDALGLYRLERSSDDTWSVTATQLVCAEAGSWSISNFTLTSDRIYITG 343
            ::...|.......|.|....:.:  ||.|......:...|::.......|:|
Yeast   312 KIIKSKNLPFVAFFVEATKCIII--LEMSEKQKGDLALKQIITFPYNVISLS------------- 361

  Fly   344 AENERLSLRVYDIATGQPASSGVPEGWLKMVLDGLGAN 381
            |.|:.     :.:......||||.:.:.|.:...|..|
Yeast   362 AHNDE-----FQVTLDNKESSGVQKNFAKFIEYNLNEN 394

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wuho	NP_572307.1	WD40 repeat	101..142	CDD:293791	10/44 (23%)
		WD40	104..361	CDD:295369	64/290 (22%)
		WD40	<107..>266	CDD:225201	49/185 (26%)
		WD40 repeat	147..184	CDD:293791	9/42 (21%)
		WD40 repeat	189..220	CDD:293791	13/33 (39%)
		WD40 repeat	233..267	CDD:293791	10/47 (21%)
TRM82	NP_010449.1	WD40 repeat	7..46	CDD:293791
		WD40 repeat	106..148	CDD:293791	10/43 (23%)
		WD40	<112..278	CDD:421866	49/170 (29%)
		WD40 repeat	152..192	CDD:293791	9/42 (21%)
		WD40 repeat	199..238	CDD:293791	14/38 (37%)
		WD40 repeat	244..279	CDD:293791	10/34 (29%)
		WD40 repeat	310..352	CDD:293791	8/43 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157345803
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3914
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4328
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004300
OrthoInspector	1	1.000	-	-		oto100132
orthoMCL	1	0.900	-	-		OOG6_103715
Panther	1	1.100	-	-	LDO	PTHR16288
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1552
SonicParanoid	1	1.000	-	-		X3033
TreeFam	1	0.960	-	-
	11	10.680