Protein Alignment Top3beta and TOP3B

DIOPT Version :10

• Sequence 1: NP_511059.2
• Gene: Top3beta / 31565
• FlyBaseID: FBgn0026015
• Length: 875
• Species: Drosophila melanogaster
• Sequence 2: NP_003926.1
• Gene: TOP3B / 8940
• HGNCID: 11993
• Length: 862
• Species: Homo sapiens
• Alignment Length: 882
• Identity: 501/882 - (56%)
• Similarity: 613/882 - (69%)
• Gaps: 27/882 - (3%)

  Fly     1 MKSVLMVAEKPSLAASLAGILSNGRCTAKRGTGNGCSTHEWTGNFRNEGSVHFRMTSVCGHVMSL 65
            ||:|||||||||||.|:|.|||.|..::.:|....||.||:||.|..: .|.|:|||||||||:|
Human     1 MKTVLMVAEKPSLAQSIAKILSRGSLSSHKGLNGACSVHEYTGTFAGQ-PVRFKMTSVCGHVMTL 64

  Fly    66 DFNKKYNCWDKVDPIQLFGCA-TEKKETNPKQNMRKFLAHEARGCDYLVLWLDCDKEGENICFEV 129
            ||..|||.||||||.:||..| |||||.|||.||.|||..|.|||||:|||||||||||||||||
Human    65 DFLGKYNKWDKVDPAELFSQAPTEKKEANPKLNMVKFLQVEGRGCDYIVLWLDCDKEGENICFEV 129

  Fly   130 MDAVKHVINNVYSDQVT-YRAHFSAITEKDIKKAMETLGHPNENEAKSVDARQELDLRIGCAFTR 193
            :|||..|:|..:..:.| :||.||:||:.||..||..||.|:.|||.||||||||||||||||||
Human   130 LDAVLPVMNKAHGGEKTVFRARFSSITDTDICNAMACLGEPDHNEALSVDARQELDLRIGCAFTR 194

  Fly   194 FQTKFFQDRYGDLDSSLISYGPCQTPTLGFCVKRHDDIQTFKPESFWHLQLLAGQPE---VTLEW 255
            ||||:||.:||||||||||:||||||||||||:|||.||:||||::|.||......:   :.|:|
Human   195 FQTKYFQGKYGDLDSSLISFGPCQTPTLGFCVERHDKIQSFKPETYWVLQAKVNTDKDRSLLLDW 259

  Fly   256 ARGRVFKKDIAIMLLNRVKEHKKATVESVASKEAYKSKPQALNTVELMRICSSGLGIGPFQAMQI 320
            .|.|||.::||.|.||..|..|:|.||:.:.||..|.:|.||||||::|:.||.||:||..|||.
Human   260 DRVRVFDREIAQMFLNMTKLEKEAQVEATSRKEKAKQRPLALNTVEMLRVASSSLGMGPQHAMQT 324

  Fly   321 AERLYTQGYISYPRTETNQYPTNFDLPAVLHVLKPSADFGEEARSILGD-IQTPRKGKDAGDHPP 384
            |||||||||||||||||..||.||||...|........:.:..:.:|.: |..||||.|||||||
Human   325 AERLYTQGYISYPRTETTHYPENFDLKGSLRQQANHPYWADTVKRLLAEGINRPRKGHDAGDHPP 389

  Fly   385 ITPMKLGNRSDFDRDTWRVYEFICRHFMGTVSRDLKYRVTTAKLSVGMETFSCTASVLIDAGFTK 449
            |||||....::...|.||:||:|.|||:.|||.|.||..:|....:|.|.|:|:...::..|||:
Human   390 ITPMKSATEAELGGDAWRLYEYITRHFIATVSHDCKYLQSTISFRIGPELFTCSGKTVLSPGFTE 454

  Fly   450 VMTWSAFGKDEPQPPFVQGTQVAINDVRLIESQTGPPDYLTESELITLMEEHGIGTDASIPVHIN 514
            ||.|.:...:|..|...:|....:.:|:::|.||.|||||||:|||||||:||||||||||||||
Human   455 VMPWQSVPLEESLPTCQRGDAFPVGEVKMLEKQTNPPDYLTEAELITLMEKHGIGTDASIPVHIN 519

  Fly   515 NICQRNYVHIENGRKLMPTTLGIVLVHGYQKIDPELVLPTMRTEVERMLTLIAQGSANFQDVLRH 579
            ||||||||.:|:||:|.||.|||||||||.|||.||||||:|:.||:.|.|||||.|:::.||.|
Human   520 NICQRNYVTVESGRRLKPTNLGIVLVHGYYKIDAELVLPTIRSAVEKQLNLIAQGKADYRQVLGH 584

  Fly   580 AIKIFKLKFMYFVKNIDSMDALFEVSFSPLAESGKAHSRCGKCRRYMKYIQTKPARLHCSHCDET 644
            .:.:||.||.|||.:|..||.|.||||||||.:||..||||||.|:|||||.||:||||||||||
Human   585 TLDVFKRKFHYFVDSIAGMDELMEVSFSPLAATGKPLSRCGKCHRFMKYIQAKPSRLHCSHCDET 649

  Fly   645 YALP-IGNVKVYREFKCPLDDFDLLAFSTGVKGRSYPFCPYCYNHPPFSDMPHLGGCNTCTNANC 708
            |.|| .|.:|:|:|.:||||||:|:.:|:|.:|:|||.||||||||||.||....|||.||:.:|
Human   650 YTLPQNGTIKLYKELRCPLDDFELVLWSSGSRGKSYPLCPYCYNHPPFRDMKKGMGCNECTHPSC 714

  Fly   709 PHSLNTLGISSCVECPTGVLVLDCTLAPTWKLGCNRCDVIINCFKGATKITVEEAKCQECGAQQV 773
            .|||:.|||..||||.:||||||.|..|.||:.||:|:|:.:||:.|.::.|....|..|.|..:
Human   715 QHSLSMLGIGQCVECESGVLVLDPTSGPKWKVACNKCNVVAHCFENAHRVRVSADTCSVCEAALL 779

  Fly   774 NVVYKSDKSKFKDGSEEKSGCIFCSADFSHLVEKHRAVASRPVRSGGGFRGGKAGRGGGGMGGAA 838
            :|.:...||.......:..||:||...|..|||...|.:..|:..||  .|.:.||
Human   780 DVDFNKAKSPLPGDETQHMGCVFCDPVFQELVELKHAASCHPMHRGG--PGRRQGR--------- 833

  Fly   839 FGSGGAVTAGGGPNAGGGVRGSRVAKDKMGQLASYFV 875
             |.|.|....|.||       .|..||||..||:|||
Human   834 -GRGRARRPPGKPN-------PRRPKDKMSALAAYFV 862

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Top3beta	NP_511059.2	TOPRIM_TopoIA_TopoIII	4..166	CDD:173782	103/163 (63%)
		TOP1Ac	171..588	CDD:238110	247/420 (59%)
TOP3B	NP_003926.1	TOPRIM_TopoIA_TopoIII	3..167	CDD:173782	103/164 (63%)
		TOP1Ac	172..593	CDD:238110	247/420 (59%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	821..854		15/51 (29%)