Protein Alignment Top3beta and TOP3

DIOPT Version :9

• Sequence 1: NP_001284938.1
• Gene: Top3beta / 31565
• FlyBaseID: FBgn0026015
• Length: 875
• Species: Drosophila melanogaster
• Sequence 2: NP_013335.1
• Gene: TOP3 / 850935
• SGDID: S000004224
• Length: 656
• Species: Saccharomyces cerevisiae
• Alignment Length: 670
• Identity: 219/670 - (32%)
• Similarity: 325/670 - (48%)
• Gaps: 93/670 - (13%)

  Fly     4 VLMVAEKPSLAASLAGILSNGRCTAKRGTGNGCSTHEWTGNF----------RNEGSVHFRMTSV 58
            ||.||||.|:|.:::.||..||.|::.      |.:.:..|:          ||..:....||||
Yeast     3 VLCVAEKNSIAKAVSQILGGGRSTSRD------SGYMYVKNYDFMFSGFPFARNGANCEVTMTSV 61

  Fly    59 CGHVMSLDFNKKYNCWDKVDPIQLFGCATEKKETNPKQNMRKFLAHEARGCDYLVLWLDCDKEGE 123
            .||:..:||:...:.|.|....:||.....:...|.::.:...:..|||..|||::|.|||:|||
Yeast    62 AGHLTGIDFSHDSHGWGKCAIQELFDAPLNEIMNNNQKKIASNIKREARNADYLMIWTDCDREGE 126

  Fly   124 NICFEVMDAVKHVINNVYSDQVTYRAHFSAITEKDIKKAMETLGHPNENEAKSVDA---RQELDL 185
            .|.:|:....|.....:.:||| |||.||.:..:.|..|..   :|:..:.|||.|   |.|:||
Yeast   127 YIGWEIWQEAKRGNRLIQNDQV-YRAVFSHLERQHILNAAR---NPSRLDMKSVHAVGTRIEIDL 187

  Fly   186 RIGCAFTRFQTKFFQDRYGDL----------------DSSLISYGPCQTPTLGFCVKRHDDIQTF 234
            |.|..|||..|:..:::..:.                ||.::|||.||.|||||.|.|.:.|:.|
Yeast   188 RAGVTFTRLLTETLRNKLRNQATMTKDGAKHRGGNKNDSQVVSYGTCQFPTLGFVVDRFERIRNF 252

  Fly   235 KPESFWHLQLLAGQPE----VTLEWARGRVFKK-------DIAIMLLNRVKEHKKATVESVASKE 288
            .||.||::||:....:    .|.:|.||.:|.:       :..|.....|     |.|..:.||.
Yeast   253 VPEEFWYIQLVVENKDNGGTTTFQWDRGHLFDRLSVLTFYETCIETAGNV-----AQVVDLKSKP 312

  Fly   289 AYKSKPQALNTVELMRICSSGLGIGPFQAMQIAERLYTQGYISYPRTETNQYPTNFDLPAVLH-- 351
            ..|.:|..|.||||.:.|:..|.:...|::..||:||.:|:||||||||:.:|...||.:::.
Yeast   313 TTKYRPLPLTTVELQKNCARYLRLNAKQSLDAAEKLYQKGFISYPRTETDTFPHAMDLKSLVEKQ 377

  Fly   352 --------------------VLKPSADFGEEARSILGDIQTPRKGK-DAGDHPPITP-MKLGNRS 394
                                :|:|      |..|.....:.||.|. |...||||.| :.||..:
Yeast   378 AQLDQLAAGGRTAWASYAASLLQP------ENTSNNNKFKFPRSGSHDDKAHPPIHPIVSLGPEA 436

  Fly   395 DFDRDTWRVYEFICRHFMGTVSRDLKYRVTTAKLSVGMETFSCTASVLIDAGFTKVMTWSAFGKD 459
            :......||||::.|||:...|.|.|.:..|..|...:|.||.:..|:::..|..|..|:.:...
Yeast   437 NVSPVERRVYEYVARHFLACCSEDAKGQSMTLVLDWAVERFSASGLVVLERNFLDVYPWARWETT 501

  Fly   460 EPQPPFVQGTQVAINDVRLIESQTGPPDYLTESELITLMEEHGIGTDASIPVHINNICQRNYVHI 524
            :..|.......|.|....:....|.||..:||||||.||:.:||||||:|..||:.|..||||..
Yeast   502 KQLPRLEMNALVDIAKAEMKAGTTAPPKPMTESELILLMDTNGIGTDATIAEHIDKIQVRNYVRS 566

  Fly   525 ENGRK---LMPTTLGIVLVHGYQKI--DPELVLPTMRTEVERMLTLIAQGSANFQDVLRHAIKIF 584
            |...|   |.|||||:.||||::.|  :.....|..|.|:|:.|..|.:|.|:..||::..::.:
Yeast   567 EKVGKETYLQPTTLGVSLVHGFEAIGLEDSFAKPFQRREMEQDLKKICEGHASKTDVVKDIVEKY 631

  Fly   585 KLKFMYFVKNIDSMDALFEV 604
            :   .|:.|.....:.|.:|
Yeast   632 R---KYWHKTNACKNTLLQV 648

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Top3beta	NP_001284938.1	PRK07219	4..781	CDD:235971	219/670 (33%)
		TOPRIM_TopoIA_TopoIII	4..166	CDD:173782	56/171 (33%)
		TOP1Ac	171..588	CDD:238110	158/475 (33%)
TOP3	NP_013335.1	TopA	2..640	CDD:223624	217/660 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0550
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	307	1.000	Inparanoid score	I483
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62408
OrthoFinder	1	1.000	-	-		FOG0000966
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.870