DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Top3beta and TOP3A

DIOPT Version :9

Sequence 1:	NP_001284938.1	Gene:	Top3beta / 31565	FlyBaseID:	FBgn0026015	Length:	875	Species:	Drosophila melanogaster
Sequence 2:	NP_201197.1	Gene:	TOP3A / 836513	AraportID:	AT5G63920	Length:	926	Species:	Arabidopsis thaliana

Alignment Length:	939	Identity:	295/939 - (31%)
Similarity:	436/939 - (46%)	Gaps:	136/939 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SVLMVAEKPSLAASLAGILSNGRCTAKRGTGNGCSTHEWTGNFRNEGS-VHFRMTSVCGHVMSLD 66
            :||.||||||:|.|:|||||.|....:.|........|:  ::...|. ....||||.||:|.|:
plant    10 TVLNVAEKPSVAKSVAGILSRGTFRTREGRSRYNKIFEF--DYAINGQPCRMLMTSVIGHLMELE 72

  Fly    67 FNKKYNCWDKVDPIQLFGCATEKKETNPKQNMRKFLAHEARGCDYLVLWLDCDKEGENICFEVMD 131
            |..:|..|...||..|:.....|.....|::::|.|..|||..|:||||||||:|||||.|||:|
plant    73 FADRYRKWHSCDPADLYQAPVMKHVPEDKKDIKKTLEEEARKSDWLVLWLDCDREGENIAFEVVD 137

  Fly   132 AVKHVINNVYSDQVTYRAHFSAITEKDIKKAMETLGHPNENEAKSVDARQELDLRIGCAFTRFQT 196
            ..:.|.:|::    ..||||||:.::||.:|::.|..||:..|::||||||:|||||.:||||||
plant   138 VCRAVKHNLF----IRRAHFSALIDRDIHEAVQNLRDPNQLFAEAVDARQEIDLRIGASFTRFQT 198

  Fly   197 KFFQDRY-----GDLDSSLISYGPCQTPTLGFCVKRHDDIQTFKPESFWHLQLLAGQPE--VTLE 254
            ...:||:     |:..|.:|||||||.|||||.|:|:.:||..:||.||.:.......|  .|..
plant   199 MLLRDRFAIDSTGEERSRVISYGPCQFPTLGFIVERYWEIQAHEPEEFWTINCSHQSEEGLATFN 263

  Fly   255 WARGRVFKKDIAIMLLNRVKEHKKATVESVA-SKEAYKSKPQALNTVELMRICSSGLGIGPFQAM 318
            |.||.:|....|::|.....|...|||.:|. .:|.:|..|..|||:||.:..|....:.....|
plant   264 WMRGHLFDYASAVILYEMCVEEPTATVMNVPHPRERFKYPPYPLNTIELEKRASRYFRLSSEHTM 328

  Fly   319 QIAERLYTQGYISYPRTETNQYPTNFDLPAVLHVLKPSADFGEEARSIL----GDIQTPRK-GKD 378
            ::||.||..|:||||||||:.:.:..||.|::........:|..|:.:|    |..:.|.. |.|
plant   329 KVAEELYQAGFISYPRTETDSFSSRTDLRAMVEEQTRHPAWGSYAQRLLEPEGGLWRNPANGGHD 393

  Fly   379 AGDHPPITPMKLGN-RSDFDRDTWRVYEFICRHFMGTVSRDLKYRVTTAKLSVGMETFSCTASVL 442
            ...||||.|.|..: .|::.||...|||.:.||::..||:......||.::.:..|.||.:...:
plant   394 DKAHPPIHPTKFSSGESNWSRDHLNVYELVVRHYLACVSQPAVAAETTVEIDIAGERFSASGRAI 458

  Fly   443 IDAGFTKVMTWSAFGKDEPQPPFVQGTQVAINDVRLIESQTGPPDYLTESELITLMEEHGIGTDA 507
            :...:.:|..:.::| ....|.:.:|.|.....:.|..:.|.||..|.|::|::.|::.||||||
plant   459 LAKNYLEVYRFESWG-GSVIPVYEKGQQFIPTTLTLDAAVTRPPPLLCEADLLSCMDKAGIGTDA 522

  Fly   508 SIPVHINNICQRNYVHIENGRKLMPTTLGIVLVHGYQKIDPELVLPTMRTEVERMLTLIAQGSAN 572
            ::..||..:..|.|...:...:..||.||..||.||..:..||..|.:|..:|..:..::.|...
plant   523 TMHDHIKKLLDRGYATKDANTRFSPTNLGEALVMGYDDMGYELWKPNLRALMEHDMNEVSVGRKT 587

  Fly   573 FQDVLRHAIKIFKLKFM----YFVKNIDSMDALFEVS----FSPLAESGKAHSRCGKCRR----- 624
            ..:||...::..|..|:    ...|.:::|...||.|    .|....:|:...||..|..
plant   588 KAEVLETCLQQMKACFLDARVKKSKLLEAMTIFFERSNNTDESESQTAGEVVRRCNLCNESDMAL 652

  Fly   625 -----------YMKYIQ----------TKPARLHCSHCDETYALPIGNVKVYREFKCPLDDFDLL 668
                       .|.|.|          |..|.:..:.|......|:  .|:..:|:
plant   653 RKNRDGNFMVGCMNYPQCRNAVWLPGPTLEASVTTNVCQSCGPGPV--YKILFKFR--------- 706

  Fly   669 AFSTGVKGRSYPFCPYCYNHPPFSDMPHL---GGCN-----------------------TCTNAN 707
              ..|:              ||..|:.||   |||:                       |..:.|
plant   707 --QIGI--------------PPGFDVNHLGCVGGCDDILKQLIDICGTGSRSQARRTPGTAPSNN 755

  Fly   708 CPHSLNTLGISSCVEC-PTGVLVLDCTLAPTWKLGCNRCDVIINCFKGATKITVEEA--KCQECG 769
            ...| ||...:.|:.| ..|....:|.         :|.....|....||....:|:  .|..||
plant   756 IQGS-NTRQSNVCIHCQQRGHASTNCP---------SRVPASRNSRPTATNPRNDESTVSCNTCG 810

  Fly   770 AQQVNVVYKSDKSKFKDGSE----EKSGCIFCSADFSHLVEKHRAVASRPVRSGGGFRGGKAGRG 830
            :|   .|.::..::...|.:    ...||.|.:.:.|  :......|:....|||..|.|..|||
plant   811 SQ---CVLRTANTEANRGRQFFSCPTQGCSFFAWEDS--INNSSGNATTGSNSGGSGRRGSRGRG 870

  Fly   831 GGGMGGAAF----GSGGA-VTAGGGPNAG 854
            .||.||.:.    |||.: |:|.|.|.:|
plant   871 RGGRGGQSSGGRRGSGTSFVSATGEPVSG 899

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Top3beta	NP_001284938.1	PRK07219	4..781	CDD:235971	269/854 (31%)
		TOPRIM_TopoIA_TopoIII	4..166	CDD:173782	69/162 (43%)
		TOP1Ac	171..588	CDD:238110	149/430 (35%)
TOP3A	NP_201197.1	PRK07219	10..702	CDD:235971	240/700 (34%)
TOP3A	NP_201197.1	zf-GRF	804..844	CDD:284302	9/42 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0550
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62408
OrthoDB	1	1.010	-	-		D373433at2759
OrthoFinder	1	1.000	-	-		FOG0000966
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.830