DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Top3beta and top3b

DIOPT Version :9

Sequence 1:	NP_001284938.1	Gene:	Top3beta / 31565	FlyBaseID:	FBgn0026015	Length:	875	Species:	Drosophila melanogaster
Sequence 2:	XP_003198651.1	Gene:	top3b / 793414	ZFINID:	ZDB-GENE-070705-37	Length:	861	Species:	Danio rerio

Alignment Length:	883	Identity:	508/883 - (57%)
Similarity:	633/883 - (71%)	Gaps:	30/883 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKSVLMVAEKPSLAASLAGILSNGRCTAKRGTGNGCSTHEWTGNFRNEGSVHFRMTSVCGHVMSL 65
            |::|||||||||||.|:|.|||.|.|:.::|....||.||:.|:|..: :|.|:|||||||||||
Zfish     1 MRTVLMVAEKPSLAQSIAKILSKGSCSTRKGLNGACSVHEYMGSFTGQ-NVRFKMTSVCGHVMSL 64

  Fly    66 DFNKKYNCWDKVDPIQLFGCA-TEKKETNPKQNMRKFLAHEARGCDYLVLWLDCDKEGENICFEV 129
            ||..|||.||||||.:||..| |||||.|||.||.|||..||:||||:|||||||||||||||||
Zfish    65 DFIGKYNNWDKVDPAELFSKAPTEKKEANPKLNMVKFLQVEAKGCDYVVLWLDCDKEGENICFEV 129

  Fly   130 MDAVKHVINNVYSDQVT-YRAHFSAITEKDIKKAMETLGHPNENEAKSVDARQELDLRIGCAFTR 193
            :||::.|:|..|.::.| |||.||:||:.||..||..||.||:|||.||||||||||||||||||
Zfish   130 LDAIQPVMNKPYGNERTVYRAKFSSITDTDICNAMNRLGEPNKNEALSVDARQELDLRIGCAFTR 194

  Fly   194 FQTKFFQDRYGDLDSSLISYGPCQTPTLGFCVKRHDDIQTFKPESFWHLQ--LLAGQPE-VTLEW 255
            ||||:||.:||:|||||||:||||||||||||:|||.||:||||::|.:|  :..|:.. :||:|
Zfish   195 FQTKYFQGKYGNLDSSLISFGPCQTPTLGFCVERHDKIQSFKPEAYWVVQAKVFKGKDSPLTLDW 259

  Fly   256 ARGRVFKKDIAIMLLNRVKEHKKATVESVASKEAYKSKPQALNTVELMRICSSGLGIGPFQAMQI 320
            .|.|||.:||..|.:|..|..|:|.|:||..||..|.:|.||||||::|:.||.||:||...|||
Zfish   260 DRVRVFDRDIGQMFVNMAKTAKEARVDSVTKKEKAKQRPLALNTVEMLRVASSALGMGPQHTMQI 324

  Fly   321 AERLYTQGYISYPRTETNQYPTNFDLPAVLHVLKPSADFGEEARSILGD-IQTPRKGKDAGDHPP 384
            |||||||||||||||||..||.||||...|.....|..:||..:::|.: |..||||.|||||||
Zfish   325 AERLYTQGYISYPRTETTHYPENFDLKGTLKQQANSTFWGETVKALLSEGINRPRKGADAGDHPP 389

  Fly   385 ITPMKLGNRSDFDRDTWRVYEFICRHFMGTVSRDLKYRVTTAKLSVGMETFSCTASVLIDAGFTK 449
            ||||:..:.::...|.||:|::|.|||:.|||.|.||..||...|:..|.|:|:...||.||:|:
Zfish   390 ITPMRAASENELGSDGWRLYDYITRHFIATVSPDCKYLQTTISFSIATEGFTCSGKTLISAGYTE 454

  Fly   450 VMTWSAFGKDEPQPPFVQGTQVAINDVRLIESQTGPPDYLTESELITLMEEHGIGTDASIPVHIN 514
            ||.|....::|..|...:|....:::::|:|.||.|||||||:|||||||:||||||||||||||
Zfish   455 VMPWQGIAQEEALPVCERGEMFTVDEIKLLEKQTNPPDYLTEAELITLMEKHGIGTDASIPVHIN 519

  Fly   515 NICQRNYVHIENGRKLMPTTLGIVLVHGYQKIDPELVLPTMRTEVERMLTLIAQGSANFQDVLRH 579
            ||||||||.:|:||||.||.|||||||||.|||.:|||||:|:.||:.|||||.|.||||.||:|
Zfish   520 NICQRNYVTVESGRKLKPTNLGIVLVHGYYKIDADLVLPTIRSAVEKQLTLIALGKANFQQVLQH 584

  Fly   580 AIKIFKLKFMYFVKNIDSMDALFEVSFSPLAESGKAHSRCGKCRRYMKYIQTKPARLHCSHCDET 644
            .:.|||.||.|||.:|..||.|.||||||:|.:||..||||||.|:|||||.||:||||||||||
Zfish   585 TLDIFKRKFHYFVDSIAGMDELMEVSFSPIAATGKPLSRCGKCHRFMKYIQAKPSRLHCSHCDET 649

  Fly   645 YALP-IGNVKVYREFKCPLDDFDLLAFSTGVKGRSYPFCPYCYNHPPFSDMPHLGGCNTCTNANC 708
            |:|| .|.:|:|:|.|||||:|:|:.:::|.:|:|||.||||:::|||.||....|||.||:.:|
Zfish   650 YSLPQNGAIKLYKELKCPLDEFELVLWTSGSRGKSYPVCPYCFSNPPFRDMKKGMGCNECTHPSC 714

  Fly   709 PHSLNTLGISSCVECPTGVLVLDCTLAPTWKLGCNRCDVIINCFKGATKITVEEAKCQECGAQQV 773
            .||||:|||..||||.|||||.|.|..|.|::.||:|:|:::.|:.|.|:.|.:..|..|.|..|
Zfish   715 QHSLNSLGIGQCVECETGVLVFDPTSGPKWRMACNKCNVVVHFFEQAHKVQVSQDSCDSCEASLV 779

  Fly   774 NVVYKSDKSKFKDGSEEKSGCIFCSADFSHLVEKHRAVASRPV-RSGGGFRGGKAGRGGGGMGGA 837
            .|.:...:|...||..:.:||:||.:.|..|||...|....|: |:||..||...|||...||
Zfish   780 IVDFNKTRSPLPDGETQHTGCVFCDSAFQDLVELKHATMRHPMHRAGGARRGRGKGRGRRPMG-- 842

  Fly   838 AFGSGGAVTAGGGPNAGGGVRGSRVAKDKMGQLASYFV 875
                      .|.|         :..||||..||:|||
Zfish   843 ----------RGNP---------KKPKDKMAALAAYFV 861

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Top3beta	NP_001284938.1	PRK07219	4..781	CDD:235971	473/783 (60%)
		TOPRIM_TopoIA_TopoIII	4..166	CDD:173782	105/163 (64%)
		TOP1Ac	171..588	CDD:238110	255/420 (61%)
top3b	XP_003198651.1	TOP1Bc	3..709	CDD:332419	437/706 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595976
Domainoid	1	1.000	517	1.000	Domainoid score	I297
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2923
Inparanoid	1	1.050	1022	1.000	Inparanoid score	I275
OMA	1	1.010	-	-		QHG62408
OrthoDB	1	1.010	-	-		D104272at33208
OrthoFinder	1	1.000	-	-		FOG0000966
OrthoInspector	1	1.000	-	-		otm26291
orthoMCL	1	0.900	-	-		OOG6_103726
Panther	1	1.100	-	-	LDO	PTHR11390
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3324
SonicParanoid	1	1.000	-	-		X3364
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	13.940