DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Top3beta and TOP3A

DIOPT Version :9

Sequence 1:	NP_001284938.1	Gene:	Top3beta / 31565	FlyBaseID:	FBgn0026015	Length:	875	Species:	Drosophila melanogaster
Sequence 2:	NP_004609.1	Gene:	TOP3A / 7156	HGNCID:	11992	Length:	1001	Species:	Homo sapiens

Alignment Length:	942	Identity:	302/942 - (32%)
Similarity:	426/942 - (45%)	Gaps:	146/942 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKSVLMVAEKPSLAASLAGILSNGRCTAKRGTGNGCSTHEWTGNFRNEGSVHFRMTSVCGHVMSL 65
            ::.||.||||...|..:|.:|||||...:.|.......:|:..:...: :|...||||.||:::.
Human    33 VRKVLCVAEKNDAAKGIADLLSNGRMRRREGLSKFNKIYEFDYHLYGQ-NVTMVMTSVSGHLLAH 96

  Fly    66 DFNKKYNCWDKVDPIQLFGCATEKKETNPKQNMRKFLAHEARGCDYLVLWLDCDKEGENICFEVM 130
            ||..::..|...:|:.||....||.......:::|.|..|.|.|..||:|.|||:|||||.||::
Human    97 DFQMQFRKWQSCNPLVLFEAEIEKYCPENFVDIKKTLERETRQCQALVIWTDCDREGENIGFEII 161

  Fly   131 DAVKHVINNVYSDQVTYRAHFSAITEKDIKKAMETLGHPNENEAKSVDARQELDLRIGCAFTRFQ 195
                ||...|..:....||.||.||...::.|.|.|..|::..:.:||.|||||||||.||||||
Human   162 ----HVCKAVKPNLQVLRARFSEITPHAVRTACENLTEPDQRVSDAVDVRQELDLRIGAAFTRFQ 222

  Fly   196 TKFFQDRYGD-LDSSLISYGPCQTPTLGFCVKRHDDIQTFKPESFWHLQLLAGQPE--VTLEWAR 257
            |...|..:.: |...|||||.||.|||||.|:|...||.|.||.|..:::.....:  |...|.|
Human   223 TLRLQRIFPEVLAEQLISYGSCQFPTLGFVVERFKAIQAFVPEIFHRIKVTHDHKDGIVEFNWKR 287

  Fly   258 GRVFKKDIAIMLLNRVKEHKKATVESVASKEAYKSKPQALNTVELMRICSSGLGIGPFQAMQIAE 322
            .|:|.....::|.....|...|||..|.||...|.:||||:||||.::.|..|.|...:.|:|||
Human   288 HRLFNHTACLVLYQLCVEDPMATVVEVRSKPKSKWRPQALDTVELEKLASRKLRINAKETMRIAE 352

  Fly   323 RLYTQGYISYPRTETNQYPTNFDLPAVLHVLKPSADFGEEARSIL--GDIQTPRKG-KDAGDHPP 384
            :|||||||||||||||.:|.:.:|..::....|...:|..|:|||  |. .|||.| |....|||
Human   353 KLYTQGYISYPRTETNIFPRDLNLTVLVEQQTPDPRWGAFAQSILERGG-PTPRNGNKSDQAHPP 416

  Fly   385 ITPMKLGNRSDFDRDTWRVYEFICRHFMGTVSRDLKYRVTTAKLSVGMETFSCTASVLIDAGFTK 449
            |.|.|..|  :...|..|:||||.|||:...|:|.:.:.||.::.:..|.|.....:::...:..
Human   417 IHPTKYTN--NLQGDEQRLYEFIVRHFLACCSQDAQGQETTVEIDIAQERFVAHGLMILARNYLD 479

  Fly   450 VMT---WSAFGKDEPQPPFVQGTQVAINDVRLIESQTGPPDYLTESELITLMEEHGIGTDASIPV 511
            |..   ||    |:..|.:.||:....:.|.:::.:|.||..|||::||.|||:|||||||:...
Human   480 VYPYDHWS----DKILPVYEQGSHFQPSTVEMVDGETSPPKLLTEADLIALMEKHGIGTDATHAE 540

  Fly   512 HINNICQRNYVHIENGRKLMPTTLGIVLVHGYQKIDPELVLPTMRTEVERMLTLIAQGSANFQDV 576
            ||..|..|.||.:...::.:|..||:.||.||..:..|:..|.:|.|:|..|.||..|..:...|
Human   541 HIETIKARMYVGLTPDKRFLPGHLGMGLVEGYDSMGYEMSKPDLRAELEADLKLICDGKKDKFVV 605

  Fly   577 LRHAIKIFKLKFMYFV---KNIDSMDALFEVSFSPLAESGKAH-------SRCGKCRRYMKYIQT 631
            ||..::.:|..|:..|   |.:|...|.:..:.:.||:....:       .:|.:|.:.| .::|
Human   606 LRQQVQKYKQVFIEAVAKAKKLDEALAQYFGNGTELAQQEDIYPAMPEPIRKCPQCNKDM-VLKT 669

  Fly   632 KP---ARLHC---SHCDETYALPIGNVKVYREFKCPLDDFDLLAFSTGVKGRSYPFCPYCYNHP- 689
            |.   ..|.|   ..|.....||...::..|:..                     .||.|..||
Human   670 KKNGGFYLSCMGFPECRSAVWLPDSVLEASRDSS---------------------VCPVCQPHPV 713

  Fly   690 ----------------PFSDMPHLGGCNTC-------------TNANCP-------HSLNTLGIS 718
                            |...:..:|||:..             ..|:.|       .|||.:..|
Human   714 YRLKLKFKRGSLPPTMPLEFVCCIGGCDDTLREILDLRFSGGPPRASQPSGRLQANQSLNRMDNS 778

  Fly   719 SCVECP-----TG-VLVLDCTLAPTWKLGCNRCDVIINCFKGATKITVEE------AKCQECGAQ 771
            ...: |     || ...|..||.|....|.:. .|..||.:.|..:||.:      .:..:|...
Human   779 QHPQ-PADSRQTGSSKALAQTLPPPTAAGESN-SVTCNCGQEAVLLTVRKEGPNRGRQFFKCNGG 841

  Fly   772 QVNVVYKSDKSKFKDGSEEKSGCIFCSADFSHLVEKHRAVASRPVRSGGGFRGGKAGRG--GGGM 834
            ..|....:|......|...                   |:|.||:   |...|...|.|  .||.
Human   842 SCNFFLWADSPNPGAGGPP-------------------ALAYRPL---GASLGCPPGPGIHLGGF 884

  Fly   835 GGAAFGSGGAVTA------------GGGPNAG 854
            |....|||...:.            ..|||.|
Human   885 GNPGDGSGSGTSCLCSQPSVTRTVQKDGPNKG 916

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Top3beta	NP_001284938.1	PRK07219	4..781	CDD:235971	282/850 (33%)
		TOPRIM_TopoIA_TopoIII	4..166	CDD:173782	59/161 (37%)
		TOP1Ac	171..588	CDD:238110	172/425 (40%)
TOP3A	NP_004609.1	TopA	35..634	CDD:223624	238/610 (39%)
		TOPRIM_TopoIA_TopoIII	35..193	CDD:173782	59/162 (36%)
		TOP1Ac	202..617	CDD:238110	172/421 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	400..424		12/24 (50%)
		YrdD	<652..728	CDD:223625	16/97 (16%)
		zf-C4_Topoisom	655..694	CDD:279704	10/39 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	774..810		9/37 (24%)
		zf-GRF	811..852	CDD:284302	9/40 (23%)
		zf-GRF	895..939	CDD:284302	4/22 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	937..1001
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62408
OrthoDB	1	1.010	-	-		D104272at33208
OrthoFinder	1	1.000	-	-		FOG0000966
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.930