DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Top3beta and top3a

DIOPT Version :9

Sequence 1:	NP_001284938.1	Gene:	Top3beta / 31565	FlyBaseID:	FBgn0026015	Length:	875	Species:	Drosophila melanogaster
Sequence 2:	XP_688695.4	Gene:	top3a / 560212	ZFINID:	ZDB-GENE-071212-2	Length:	998	Species:	Danio rerio

Alignment Length:	948	Identity:	298/948 - (31%)
Similarity:	426/948 - (44%)	Gaps:	150/948 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKSVLMVAEKPSLAASLAGILSNGRCTAKRGTGNGCST----HEWTGNFRNEGSVHFRMTSVCGH 61
            :|.||.||||...|..:|.|:||||...:    .|||.    :|:..|...: :|...||||.||
Zfish    30 IKKVLCVAEKNDAAKGIAEIMSNGRSRRR----EGCSVYNKIYEYEYNLFGQ-NVTVNMTSVSGH 89

  Fly    62 VMSLDFNKKYNCWDKVDPIQLFGCATEKKETNPKQNMRKFLAHEARGCDYLVLWLDCDKEGENIC 126
            :::|:|...:..|....|:.||....||........:::.|..|.|.|..|::|.|||:|||||.
Zfish    90 LLALEFKAPFQKWHSCSPVLLFDAEVEKYCPENFIPIKRTLEREVRQCQALIVWTDCDREGENIG 154

  Fly   127 FEVMDAVKHVINNVYSDQVTYRAHFSAITEKDIKKAMETLGHPNENEAKSVDARQELDLRIGCAF 191
            ||::|..|.|..|:   || :||.||.||...|::|.|||..|:.|.:.:||.|||||||||.:|
Zfish   155 FEIIDVCKAVKPNI---QV-FRARFSEITPNSIRRACETLTEPDINVSDAVDVRQELDLRIGASF 215

  Fly   192 TRFQT----KFFQDRYGDLDSSLISYGPCQTPTLGFCVKRHDDIQTFKPESFWHLQLLAGQPE-- 250
            |||||    |.|.:   .|...|||||.||.|||||.|:|...||.|.||:|:.::::....|
Zfish   216 TRFQTLRLQKIFPE---SLSDQLISYGSCQFPTLGFVVERFKAIQAFIPETFFKIKVVHEPNEEE 277

  Fly   251 -VTLEWARGRVFKKDIAIMLLNRVKEHKKATVESVASKEAYKSKPQALNTVELMRICSSGLGIGP 314
             |...|.|.|:|.....::|.....|...|.|.||.||...|.:|..|:||||.::.|..|.|..
Zfish   278 SVEFNWKRHRLFNHTACLVLYQMCMEEPMAKVISVTSKPKSKWRPLPLDTVELEKLASRKLRISA 342

  Fly   315 FQAMQIAERLYTQGYISYPRTETNQYPTNFDLPAVLHVLKPSADFGEEARSIL-GDIQTPRKG-K 377
            .:.|:|||:|||||:|||||||||.:|.|.:|..::.......::|..|:.|| ....|||.| |
Zfish   343 KETMKIAEKLYTQGFISYPRTETNMFPQNLNLTRLVEQQTQDQEWGNFAQRILESGGPTPRNGNK 407

  Fly   378 DAGDHPPITPMKLGNRSDFDRDTWRVYEFICRHFMGTVSRDLKYRVTTAKLSVGMETFSCTASVL 442
            ....||||.|.|..|  ....:..|:||||.|||:...|:|.:.:..|.::.:..|.||.:...:
Zfish   408 SDQAHPPIHPTKYTN--GLQGNEKRLYEFIVRHFLACCSKDAQGQEVTVEIDIAEERFSASGLTI 470

  Fly   443 IDAGFTKVMTWSAFGKDEPQPPFVQGTQVAINDVRLIESQTGPPDYLTESELITLMEEHGIGTDA 507
            |...:.:|..:..: .::..|.:...|......:.::|.||.||..|||::||:|||:|||||||
Zfish   471 IARNYLEVYPYDKW-YNKVIPSYSPNTTFQPTAIEMVEGQTSPPQLLTEADLISLMEKHGIGTDA 534

  Fly   508 SIPVHINNICQRNYVHIENGRKLMPTTLGIVLVHGYQKIDPELVLPTMRTEVERMLTLIAQGSAN 572
            :...||..|..|.||.:...::.:|..||:.||.||..:..|:..|.:|.|:|..|.|:::|..|
Zfish   535 THAEHIETIKSRMYVGLTADQRFLPGELGMGLVEGYNSMGYEMSKPDLRAELEADLKLVSEGRKN 599

  Fly   573 FQDVLRHAIKIFKLKFMYFVKNIDSMDALFEVSFSPLAESGKAHS----------RCGKCRRYMK 627
            ...||.:.:..:|..|:..|:....:|........|..|..:...          :|.:|.|.|.
Zfish   600 KASVLSYHVAKYKAVFIESVRKAKKLDEALSNYLGPAQEIAEQEQVELEIPLPVRKCPQCNRDMV 664

  Fly   628 YIQTKPAR---LHC---SHCDETYALPIGNVKVYREFKCPLDDFDLLAFSTGVKGRSYPFCPYCY 686
            ..:.|.:.   |.|   ..|......|...::|                     .|....||.|.
Zfish   665 LKKKKDSTGMLLSCLGYPACKAAVWFPDTVLEV---------------------SRDESICPTCR 708

  Fly   687 NHP-----------------PFSDMPHLGGCNTC--------------------TNANCPHSLNT 714
            .||                 |...:..:|||:..                    .|.:...|.:.
Zfish   709 PHPVHMLKFKFKRGSLPPMMPLEFVGCIGGCDDTLREVLNLKYLRGRDAESAPQANNSSRSSQHH 773

  Fly   715 LGISSCVECPTGVLVL---------DCTL--APTWKLGCNRCDVIINCFKGATKITVEEAKCQEC 768
            :..:|....|:.|..:         |..|  .|:.:.|.    ::.||.:.|..:||.:.
Zfish   774 IHRTSSAPPPSRVENIRPPAPRPRADPGLQPPPSTQGGA----IVCNCGQDALLLTVRKE----- 829

  Fly   769 GAQQVNVVYKSDKSKFKDGSEEKSGCIFCSAD---FSHLVEKHRAVAS---RPVRSGGGFRGGKA 827
            |..|....||.:....|         .|..||   ...:.|::|...|   :|.|...||  |..
Zfish   830 GPNQGRQFYKCNTGDCK---------FFLWADQPPEQGVPERNRGPLSQNVQPPRPSNGF--GNV 883

  Fly   828 G------RGGGGMGGAAF-----GSGGAVTAGGGPNAG 854
            .      ||.||..|...     .|........|||.|
Zfish   884 SQQRQNHRGSGGDEGETMCNCNEPSVTRTVMKEGPNKG 921

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Top3beta	NP_001284938.1	PRK07219	4..781	CDD:235971	275/853 (32%)
		TOPRIM_TopoIA_TopoIII	4..166	CDD:173782	64/165 (39%)
		TOP1Ac	171..588	CDD:238110	165/425 (39%)
top3a	XP_688695.4	TopA	32..624	CDD:223624	234/606 (39%)
		TOPRIM_TopoIA_TopoIII	32..190	CDD:173782	64/166 (39%)
		TOP1Ac	195..615	CDD:238110	165/425 (39%)
		YrdD	638..>721	CDD:223625	17/103 (17%)
		zf-C4_Topoisom	653..692	CDD:279704	8/38 (21%)
		zf-GRF	815..854	CDD:284302	13/52 (25%)
		zf-GRF	900..944	CDD:284302	5/22 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62408
OrthoDB	1	1.010	-	-		D104272at33208
OrthoFinder	1	1.000	-	-		FOG0000966
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.930