DRSC/TRiP Functional Genomics Resources

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Protein Alignment Top3beta and Top3alpha

DIOPT Version :10

Sequence 1:NP_511059.2 Gene:Top3beta / 31565 FlyBaseID:FBgn0026015 Length:875 Species:Drosophila melanogaster
Sequence 2:NP_523602.2 Gene:Top3alpha / 35236 FlyBaseID:FBgn0040268 Length:1250 Species:Drosophila melanogaster


Alignment Length:932 Identity:293/932 - (31%)
Similarity:418/932 - (44%) Gaps:184/932 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 LMVAEKPSLAASLAGILSNGRCTAKRGTGNGCSTHEWTGNFRNEGSVHFRMTSVCGHVMSLDFNK 69
            |.||||...|.::||:||||....:.|........::....|.: :....||||.||:|.|.|..
  Fly    29 LNVAEKNDAAKTIAGLLSNGAAQRREGYSVYNKVFDFEAPVRGQ-NAKMVMTSVSGHMMQLAFQV 92

  Fly    70 KYNCWDKVDPIQLFGCATEKKETNPKQNMRKFLAHEARGCDYLVLWLDCDKEGENICFEVMDAVK 134
            .|..|..|||..||....:|...:..:.:::.|..|.|||..|::|.|||:|||||.:|::|..:
  Fly    93 SYKNWRTVDPRSLFDAPVKKGVGSDYEPIKRTLEREVRGCQGLIIWTDCDREGENIGYEIIDVCR 157

  Fly   135 HVINNVYSDQVTYRAHFSAITEKDIKKAMETLGHPNENEAKSVDARQELDLRIGCAFTRFQT--- 196
            .:..|:    ..|||.||.||...:::|::.||.|::.::.:||.|.|||||.|.|.|||||   
  Fly   158 AIKPNI----SVYRATFSEITTVAVRRALQQLGQPDKRQSDAVDVRTELDLRTGAAITRFQTMRL 218

  Fly   197 -KFFQDRYGDLDSSLISYGPCQTPTLGFCVKRHDDIQTFKPESFWHLQLLAGQPEVTLE--WARG 258
             :.|.::..|   .|||||.||.|||||..:|:.:|:.|..|.||.:::|....::|:|  |||.
  Fly   219 QRLFPEKIAD---KLISYGSCQIPTLGFVAERYKEIEAFVSEPFWKIKVLHTIDDLTVEFNWARN 280

  Fly   259 RVFKKDIA--IMLLNRVKEHKKATVESVASKEAYKSKPQALNTVELMRICSSGLGIGPFQAMQIA 321
            |:|.|:..  .:||...:...:|.||||..|..:|.:|..|:|||:.::.|..|.:...:.|.||
  Fly   281 RLFDKEACENYLLLCLAEPDPRALVESVTVKPKHKWRPTPLDTVEMEKLGSRKLKLSAKETMTIA 345

  Fly   322 ERLYTQGYISYPRTETNQYPTNFDLPAVLHVLKPSADFGEEARSILGDIQTPRKG-KDAGDHPPI 385
            |:|||:|:||||||||||:...|.|..::.:.....|:|..|:.::.....||.| |....||||
  Fly   346 EKLYTKGFISYPRTETNQFSKEFALAPLVEMQTGHRDWGAFAQRVIEWGPNPRNGNKSDQAHPPI 410

  Fly   386 TPMKL-----GNRSDFDRDTWRVYEFICRHFMGTVSRDLKYRVTTAKLSVGMETFSCTASVLIDA 445
            .|.||     ||.:       ||||.:.|||:..||:|.....|...:.:..|.|:....|:.:.
  Fly   411 HPTKLAENLQGNEA-------RVYELVVRHFLACVSKDAVGSETLVHIDIAGEKFTANGLVIHER 468

  Fly   446 GFTKVMT---WSAFGKDEPQPPFVQGTQVAINDVRLIESQTGPPDYLTESELITLMEEHGIGTDA 507
            .:..|..   |||    :....:..|.:....:|.|.|..|..|..|||::||.|||:|||||||
  Fly   469 NYLDVYVYDKWSA----KQIHHYENGQRFEPTEVSLHEGATTAPPLLTEADLIALMEKHGIGTDA 529

  Fly   508 SIPVHINNICQRNYVHIENGRKLMPTTLGIVLVHGYQKIDPELVLPTMRTEVERMLTLIAQGSAN 572
            :...|||.|.:|.|:.:.:...|:|..:|:.|..||..::..|..|.:|.|.|..|.||.||..:
  Fly   530 THAEHINTIKERGYIGVLDKGFLVPGVIGMGLYEGYDAMELALAKPQLRAEFELDLKLICQGQKD 594

  Fly   573 FQDVLRHAIKIFKLKFMYFVKNIDSMDALFEVSFSPLAESGKAHSRCGKCRRYMKYIQTKPARLH 637
            .:.||...|..:|..:......|.:|||  ::|                            ||: 
  Fly   595 PKVVLTEQIAKYKQAYQQITDKITAMDA--KIS----------------------------ARI- 628

  Fly   638 CSHCDETYALPIGNVKVYREFKCPLDDFDLLAFSTGVKGRSYPFCPYCYNHPPFSDMPHLG---- 698
                :||   |..|..|.       :..|..|.|.|:. :|...||.| |..|.:..|...    
  Fly   629 ----NET---PAANSAVQ-------EGADGSAPSHGII-QSIFQCPKC-NEAPLALKPKKNQQGW 677

  Fly   699 --GCNTCTNANCPHSLNTLGISS-----------CVECPTGVLVLDCTLA----------PT-WK 739
              |||     |.|...|.:.:.:           |..|..|..:|...|:          |: |.
  Fly   678 YIGCN-----NFPDCKNAVWLPTECKDASVLDECCPTCGDGYRMLKFRLSTPYYRGVFGTPSGWY 737

  Fly   740 LGCNRCDVIINCFKGATKITVEEAKCQECGAQQVNVVYKSDKSKFKDGSEEKSGCIFCSADFSHL 804
            ..|..||   |.|:....|.::..|                          |.|.|.        
  Fly   738 KTCLPCD---NLFRTTFNINLDSVK--------------------------KVGGIV-------- 765

  Fly   805 VEKHRAVASRPVRSGGGF-----RGGKAGR-----------------GGGGMGGAAFGSGGAVTA 847
                     ..||.|||.     .||.:||                 ||||.||...|:||..:.
  Fly   766 ---------GEVRGGGGGPGPGPGGGGSGRGAGSGGWSSGPGGGGSGGGGGSGGWGSGTGGGGSG 821

  Fly   848 GGGPNAGGGVRGSRVAKDKMGQ 869
            |.|...|||..|....|...|:
  Fly   822 GWGSGTGGGGLGGGKGKKPGGE 843

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Top3betaNP_511059.2 TOPRIM_TopoIA_TopoIII 4..166 CDD:173782 57/160 (36%)
TOP1Ac 171..588 CDD:238110 161/433 (37%)
Top3alphaNP_523602.2 TOPRIM_TopoIA_TopoIII 27..185 CDD:173782 57/160 (36%)
TOP1Ac 194..608 CDD:238110 160/427 (37%)
zf-C4_Topoisom 658..694 CDD:307520 12/41 (29%)
zf-GRF 1033..1076 CDD:462017
zf-GRF 1150..1193 CDD:462017
Blue background indicates that the domain is not in the aligned region.

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