DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Top3beta and Top3a

DIOPT Version :9

Sequence 1:	NP_001284938.1	Gene:	Top3beta / 31565	FlyBaseID:	FBgn0026015	Length:	875	Species:	Drosophila melanogaster
Sequence 2:	XP_038943191.1	Gene:	Top3a / 303194	RGDID:	1309320	Length:	1003	Species:	Rattus norvegicus

Alignment Length:	929	Identity:	308/929 - (33%)
Similarity:	428/929 - (46%)	Gaps:	118/929 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKSVLMVAEKPSLAASLAGILSNGRCTAKRGTGNGCSTHEWTGNFRNEGSVHFRMTSVCGHVMSL 65
            ::.||.||||...|..:|.:|||||...|.|.......:|:..:...: :|...||||.||:::.
  Rat    33 VRKVLCVAEKNDAAKGIADLLSNGRMRRKEGLSKFNKIYEFDYHLYGQ-NVTMIMTSVSGHLLAH 96

  Fly    66 DFNKKYNCWDKVDPIQLFGCATEKKETNPKQNMRKFLAHEARGCDYLVLWLDCDKEGENICFEVM 130
            ||..::..|...:|:.||....||.......:::|.|..|.:.|..||:|.|||:|||||.||::
  Rat    97 DFQMQFRKWQSCNPLVLFEAEIEKYCPENFIDIKKTLERETQHCQALVIWTDCDREGENIGFEII 161

  Fly   131 DAVKHVINNVYSDQVTYRAHFSAITEKDIKKAMETLGHPNENEAKSVDARQELDLRIGCAFTRFQ 195
                ||...|..:....||.||.||...::.|.|.|..|::..:.:||.|||||||||.||||||
  Rat   162 ----HVCKAVKPNLQVLRARFSEITHHAVRAACEHLTEPDQRVSDAVDVRQELDLRIGAAFTRFQ 222

  Fly   196 TKFFQDRYGD-LDSSLISYGPCQTPTLGFCVKRHDDIQTFKPESFWHLQLLAGQPEVTLE--WAR 257
            |...|..:.: |...|||||.||.|||||.|:|...||.|.||.|..:::.....:.|:|  |.|
  Rat   223 TLRLQRIFPEVLAEQLISYGSCQFPTLGFVVERFKAIQAFVPEVFHRIKVTHDHKDGTVEFNWKR 287

  Fly   258 GRVFKKDIAIMLLNRVKEHKKATVESVASKEAYKSKPQALNTVELMRICSSGLGIGPFQAMQIAE 322
            .|:|.....::|.....|...|||..|.||...|.:||||:||||.::.|..|.|...:.|:|||
  Rat   288 YRLFNHTACLVLYQLCMEDPMATVVEVRSKPKSKWRPQALDTVELEKLASRKLRINAKETMRIAE 352

  Fly   323 RLYTQGYISYPRTETNQYPTNFDLPAVLHVLKPSADFGEEARSIL--GDIQTPRKG-KDAGDHPP 384
            :|||||||||||||||.:|.:.:|..::........:|..|::||  |. .|||.| |....|||
  Rat   353 KLYTQGYISYPRTETNIFPKDLNLVTLVEQQTQDPHWGAFAQNILERGG-PTPRNGNKSDQAHPP 416

  Fly   385 ITPMKLGNRSDFDRDTWRVYEFICRHFMGTVSRDLKYRVTTAKLSVGMETFSCTASVLIDAGFTK 449
            |.|.|.  .|....|..|:||||.|||:...|:|.:.:.||.::.:..|.|.....:::...:..
  Rat   417 IHPTKY--TSSLQGDDRRLYEFIVRHFLACCSQDAQGQETTVEIDIAQERFVAHGLIILARNYLD 479

  Fly   450 VMT---WSAFGKDEPQPPFVQGTQVAINDVRLIESQTGPPDYLTESELITLMEEHGIGTDASIPV 511
            |..   ||    |:..|.:.||.:...:.|.:::.:|.||..|||::||.|||:|||||||:...
  Rat   480 VYPYDHWS----DKLLPVYEQGFRFQPSTVEMVDGETSPPQLLTEADLIALMEKHGIGTDATHAE 540

  Fly   512 HINNICQRNYVHIENGRKLMPTTLGIVLVHGYQKIDPELVLPTMRTEVERMLTLIAQGSANFQDV 576
            ||..|..|.||.:.:.::.:|..||:.||.||..:..|:..|.:|.|:|..|.||.:|..:...|
  Rat   541 HIETIKARMYVGLTSDKRFLPGHLGMGLVEGYDSMGYEMSKPNLRAELEADLKLICEGKKDKFQV 605

  Fly   577 LRHAIKIFKLKFMYFVKNIDSMDALFEVSFSPLAESGKAHS----------RCGKCRRYMKYIQT 631
            ||..::.:|..|:..|.....:|...........|..:...          :|.:|.:.| .::|
  Rat   606 LRQQVQKYKQVFIEAVAKAKKLDEALSQYLGERTEVAQQEEIYPAMPEPVRKCPQCNKDM-VLKT 669

  Fly   632 KPA---RLHCS---HCDETYALPIGNVKVYREFK----C-PLDDFDL-LAFSTGVKGRSYPF--- 681
            |.:   .|.|:   .|......|...::..|:..    | |...:.| |.|..|....|.|.
  Rat   670 KKSGGFYLSCTGFPECRSAVWFPDSVLEASRDSSVCSVCQPAPVYRLKLKFKRGSLPPSMPLEFV 734

  Fly   682 -----CPYCYNH---------PPFSDMP--HLGGCNTCTNANCPHSLNTLGISS------CVECP 724
                 |......         ||.:..|  ||         ....:||.:..|.      .|...
  Rat   735 GCIGGCDETLKEIFGLRFSRAPPRASQPSGHL---------QASQALNRMDSSQRSLSQPLVNRH 790

  Fly   725 TG--VLVLDCTLAPTWKLGCNRCDVIINCFKGATKITVEEAKCQECGAQQVNVVYKSDKSKFKDG 787
            ||  ..|....|.||.....|  .|..||.:.|..:||.:.     |..|....||.      .|
  Rat   791 TGPSKAVAQTLLPPTAAAEGN--SVTCNCGREAVLLTVRKQ-----GPNQGRHFYKC------SG 842

  Fly   788 SEEKSGC-IFCSADFSHLV--EKHRAVASRPVRSGG---GFRGGKAGRGGGGMGGAAFGSGGAVT 846
            .:    | .|..||.||..  ....:|:..|..|.|   ||  |....|.|.:||.  |.|||..
  Rat   843 GD----CNFFLWADSSHPTGGGPPTSVSRPPGNSVGCPSGF--GSHMDGFGSLGGD--GDGGASC 899

  Fly   847 AGG-----------GPNAG 854
            ..|           |||.|
  Rat   900 LCGQPAVTRTVQKDGPNKG 918

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Top3beta	NP_001284938.1	PRK07219	4..781	CDD:235971	281/834 (34%)
		TOPRIM_TopoIA_TopoIII	4..166	CDD:173782	59/161 (37%)
		TOP1Ac	171..588	CDD:238110	171/425 (40%)
Top3a	XP_038943191.1	TOPRIM_TopoIA_TopoIII	35..193	CDD:173782	59/162 (36%)
		TOP1Ac	202..617	CDD:238110	171/421 (41%)
		zf-C4_Topoisom	655..694	CDD:307520	9/39 (23%)
		zf-GRF	813..854	CDD:399670	15/55 (27%)
		zf-GRF	898..941	CDD:399670	5/21 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62408
OrthoDB	1	1.010	-	-		D104272at33208
OrthoFinder	1	1.000	-	-		FOG0000966
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.930