Protein Alignment Top3beta and Top3b

DIOPT Version :10

• Sequence 1: NP_511059.2
• Gene: Top3beta / 31565
• FlyBaseID: FBgn0026015
• Length: 875
• Species: Drosophila melanogaster
• Sequence 2: NP_001099331.1
• Gene: Top3b / 287930
• RGDID: 1309468
• Length: 862
• Species: Rattus norvegicus
• Alignment Length: 883
• Identity: 505/883 - (57%)
• Similarity: 610/883 - (69%)
• Gaps: 29/883 - (3%)

  Fly     1 MKSVLMVAEKPSLAASLAGILSNGRCTAKRGTGNGCSTHEWTGNFRNEGSVHFRMTSVCGHVMSL 65
            ||:|||||||||||.|:|.|||.|..::.:|....||.|::||.|..: .|||:|||||||||:|
  Rat     1 MKTVLMVAEKPSLAQSIAKILSRGNMSSHKGLNGACSVHKYTGTFAGQ-PVHFKMTSVCGHVMTL 64

  Fly    66 DFNKKYNCWDKVDPIQLFGCA-TEKKETNPKQNMRKFLAHEARGCDYLVLWLDCDKEGENICFEV 129
            ||..|||.||||||.:||..| |||||.|||.||.|||..|.|||||:|||||||||||||||||
  Rat    65 DFLGKYNKWDKVDPAELFSQAPTEKKEANPKLNMVKFLQVEGRGCDYVVLWLDCDKEGENICFEV 129

  Fly   130 MDAVKHVINNVYSDQVT-YRAHFSAITEKDIKKAMETLGHPNENEAKSVDARQELDLRIGCAFTR 193
            :|||..|:||.::.:.| :||.||:||:.||..||..|..|:.|||.||||||||||||||||||
  Rat   130 LDAVLPVLNNAHNGEKTVFRARFSSITDTDICNAMTRLTEPDHNEALSVDARQELDLRIGCAFTR 194

  Fly   194 FQTKFFQDRYGDLDSSLISYGPCQTPTLGFCVKRHDDIQTFKPESFWHLQLLA---GQPEVTLEW 255
            ||||:||.:||||||||||:||||||||||||:|||.||:||||::|.||...   .:..:.|:|
  Rat   195 FQTKYFQGKYGDLDSSLISFGPCQTPTLGFCVERHDKIQSFKPETYWVLQAKVHTDKEESLLLDW 259

  Fly   256 ARGRVFKKDIAIMLLNRVKEHKKATVESVASKEAYKSKPQALNTVELMRICSSGLGIGPFQAMQI 320
            .|.|||.::||.|.||..|..|:|.||:.:.||..|.:|.||||||::|:.||.||:||..|||:
  Rat   260 DRVRVFDREIAQMFLNMTKLEKEAWVEATSKKEKAKQRPLALNTVEMLRVASSALGMGPQHAMQV 324

  Fly   321 AERLYTQGYISYPRTETNQYPTNFDLPAVLHVLKPSADFGEEARSILGD-IQTPRKGKDAGDHPP 384
            |||||||||||||||||..||.||||...|........:.:..:.:|.: |..||||.|||||||
  Rat   325 AERLYTQGYISYPRTETTHYPENFDLKGSLRQQANHPYWADSVKQLLAEGINRPRKGHDAGDHPP 389

  Fly   385 ITPMKLGNRSDFDRDTWRVYEFICRHFMGTVSRDLKYRVTTAKLSVGMETFSCTASVLIDAGFTK 449
            |||||....::...|.||:||:|.|||:.|||.|.||..:|....:|.|.|:|....:|..|||:
  Rat   390 ITPMKSATEAELGGDAWRLYEYITRHFIATVSHDCKYLQSTISFRIGPEHFTCMGKTVISPGFTE 454

  Fly   450 VMTWSAFGKDEPQPPFVQGTQVAINDVRLIESQTGPPDYLTESELITLMEEHGIGTDASIPVHIN 514
            :|.|.:...:|..|...:|....:.:|:::|.||.|||||||:|||||||:||||||||||||||
  Rat   455 IMPWQSVPLEESLPTCQKGDTFTVGEVKMLEKQTSPPDYLTEAELITLMEKHGIGTDASIPVHIN 519

  Fly   515 NICQRNYVHIENGRKLMPTTLGIVLVHGYQKIDPELVLPTMRTEVERMLTLIAQGSANFQDVLRH 579
            ||||||||.:||||:|.||.|||||||||.|||.||||||:|:.||:.|.|||||.||:..||.|
  Rat   520 NICQRNYVTVENGRRLKPTNLGIVLVHGYHKIDAELVLPTIRSAVEKQLNLIAQGKANYHQVLGH 584

  Fly   580 AIKIFKLKFMYFVKNIDSMDALFEVSFSPLAESGKAHSRCGKCRRYMKYIQTKPARLHCSHCDET 644
            .:.|||.||.|||.:|..||.|.||||||||.:||..||||||.|:|||||.||:||||||||||
  Rat   585 TLDIFKRKFHYFVDSIAGMDELMEVSFSPLAATGKPLSRCGKCHRFMKYIQAKPSRLHCSHCDET 649

  Fly   645 YALP-IGNVKVYREFKCPLDDFDLLAFSTGVKGRSYPFCPYCYNHPPFSDMPHLGGCNTCTNANC 708
            |.|| .|.:|:|:|.:||||||:|:.:|:|.:|:|||.||||||||||.||....|||.||:..|
  Rat   650 YTLPQNGTIKLYKELRCPLDDFELVLWSSGSRGKSYPLCPYCYNHPPFRDMKKGMGCNECTHPTC 714

  Fly   709 PHSLNTLGISSCVECPTGVLVLDCTLAPTWKLGCNRCDVIINCFKGATKITVEEAKCQECGAQQV 773
            .|||:.|||..||||..||||||.|..|.||:.||.|.|:.:||..|.::.|....|..|.|..:
  Rat   715 QHSLSMLGIGQCVECENGVLVLDPTSGPKWKVACNTCSVVAHCFDNAHRVRVSADTCNTCEAALL 779

  Fly   774 NVVYKSDKSKFKDGSEEKSGCIFCSADFSHLVEKHRAVASRPVRSGG-GFRGGKAGRGGGGMGGA 837
            :|.:...||.......:.:|||||...|..|||...|.:..|:..|| |.|.|: ||..|.
  Rat   780 DVDFNKAKSPLPGNETQHTGCIFCDTVFQELVELKHAASCHPMHRGGPGRRQGR-GRARGR---- 839

  Fly   838 AFGSGGAVTAGGGPNAGGGVRGSRVAKDKMGQLASYFV 875
                    ...|.||       .|..||||..||:|||
  Rat   840 --------RPPGKPN-------PRRPKDKMSALAAYFV 862

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Top3beta	NP_511059.2	TOPRIM_TopoIA_TopoIII	4..166	CDD:173782	104/163 (64%)
		TOP1Ac	171..588	CDD:238110	250/420 (60%)
Top3b	NP_001099331.1	TOPRIM_TopoIA_TopoIII	3..167	CDD:173782	104/164 (63%)
		TOP1Ac	172..593	CDD:238110	250/420 (60%)