DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Top3beta and top3

DIOPT Version :9

Sequence 1:	NP_001284938.1	Gene:	Top3beta / 31565	FlyBaseID:	FBgn0026015	Length:	875	Species:	Drosophila melanogaster
Sequence 2:	NP_596761.1	Gene:	top3 / 2539881	PomBaseID:	SPBC16G5.12c	Length:	622	Species:	Schizosaccharomyces pombe

Alignment Length:	615	Identity:	213/615 - (34%)
Similarity:	326/615 - (53%)	Gaps:	33/615 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 VLMVAEKPSLAASLAGILSNGRCTAKRGTGNGCSTHEWTGNF-RNEGSVHFRMTSVCGHVMSLDF 67
            ||.||||.|:|.|:|.||..|....:.........::::.|| .|.||....||||.||:....|
pombe     3 VLCVAEKNSIAKSVASILGGGHVRRRDTRSKYVKNYDFSFNFGGNVGSSDVTMTSVSGHLTEASF 67

  Fly    68 NKKYNCWDKVDPIQLFGC----ATEKKETNPKQNMRKFLAHEARGCDYLVLWLDCDKEGENICFE 128
            ..:|:.|..|....||..    :..|.......|::|    |||...||.:|.|||:|||:|..|
pombe    68 PSEYSSWSSVPQDVLFDAQIITSVSKNAEVLADNIKK----EARNAQYLYIWTDCDREGEHIGVE 128

  Fly   129 VMDAVKHVINNVYSDQVTYRAHFSAITEKDIKKAMETLGHPNENEAKSVDARQELDLRIGCAFTR 193
            :.:..:  .:|. |.|| .||.|:.:....|..|.:.....::|.|.:||||.|||.|:|..|||
pombe   129 ISNVAR--ASNP-SIQV-IRADFNNLERSHIISAAKRPRDVSKNAADAVDARIELDFRLGAIFTR 189

  Fly   194 FQTKFFQDRYGDLDSSLISYGPCQTPTLGFCVKRHDDIQTFKPESFWHLQLLAGQPEVTLE--WA 256
            .||...|..:..|.:.:|||||||.|||||.|.|...::.|.||::|||:.:..:...|::  |.
pombe   190 LQTIQLQKSFDILQNKIISYGPCQFPTLGFVVDRWQRVEDFVPETYWHLRFVDKRQGKTIQFNWE 254

  Fly   257 RGRVFKKDIAIMLLNRVKEHKKATVESVASKEAYKSKPQALNTVELMRICSSGLGIGPFQAMQIA 321
            |.:||.:...:::|....|.|.|.|.::..|...|.||..|:||||.::....|.|...:.:::|
pombe   255 RAKVFDRLTTMIILENCLECKTAKVVNITQKPKTKYKPLPLSTVELTKLGPKHLRISAKKTLELA 319

  Fly   322 ERLYTQGYISYPRTETNQYPTNFDLPAVLHVLKPSADFGEEARSIL-GDIQTPRKGK-DAGDHPP 384
            |.|||.|::|||||||:|:.::.:|.|::..|..:.::...|..:| ||.:.||||| :...|||
pombe   320 ENLYTNGFVSYPRTETDQFDSSMNLHAIIQKLTGAQEWDSYAEGLLAGDYRPPRKGKHNDRAHPP 384

  Fly   385 ITPMKLGNRSDF-DRDTWRVYEFICRHFMGTVSRDLKYRVTTAKLSVGMETFSCTASVLIDAGFT 448
            |.|:::.:||.. .:|.|:|||.|.|.|:...|.:.|...|..::.:..|.||....::.:..:.
pombe   385 IHPVQMVHRSALPSQDHWKVYELITRRFLACCSDNAKGAETLVQVKMEEELFSKKGLLVTEKNYL 449

  Fly   449 KVMTWSAFGKDEPQPPFVQGTQVAINDVRLIESQTGPPDYLTESELITLMEEHGIGTDASIPVHI 513
            :|..:..:...:..|.:....:...:.:.:::|.|..|.|:||.|||.||:.:||||||::..||
pombe   450 EVYPYEKWESSDQLPEYRLHEEFQPHILDMMDSSTSSPSYITEPELIALMDANGIGTDATMAEHI 514

  Fly   514 NNICQRNYVHIENGR-----KLMPTTLGIVLVHGYQKIDPE--LVLPTMRTEVERMLTLIAQGSA 571
            ..:.:|.||.....|     :.:|::||:.|..||.:|..|  |..|.:|.|:|..|..|..|..
pombe   515 EKVQEREYVIKRKKRGQGVTEFVPSSLGVALAKGYDEIGLEWSLTKPFLRKEMEVQLKNIENGQL 579

  Fly   572 NFQDVLRHAI-----KIFKLKFMYF--VKN 594
            | ::||.|.|     .:|.|....|  :||
pombe   580 N-RNVLVHMILTQFRDVFHLTKQRFDCLKN 608

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Top3beta	NP_001284938.1	PRK07219	4..781	CDD:235971	213/615 (35%)
		TOPRIM_TopoIA_TopoIII	4..166	CDD:173782	56/166 (34%)
		TOP1Ac	171..588	CDD:238110	154/433 (36%)
top3	NP_596761.1	TOPRIM_TopoIA_TopoIII	2..162	CDD:173782	56/166 (34%)
		TopA	3..615	CDD:223624	213/615 (35%)
		TOP1Ac	168..596	CDD:238110	152/428 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0550
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	325	1.000	Inparanoid score	I539
OMA	1	1.010	-	-		QHG62408
OrthoFinder	1	1.000	-	-		FOG0000966
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.870