DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Top3beta and Top3b

DIOPT Version :9

Sequence 1:	NP_001284938.1	Gene:	Top3beta / 31565	FlyBaseID:	FBgn0026015	Length:	875	Species:	Drosophila melanogaster
Sequence 2:	NP_001313505.1	Gene:	Top3b / 21976	MGIID:	1333803	Length:	862	Species:	Mus musculus

Alignment Length:	883	Identity:	505/883 - (57%)
Similarity:	612/883 - (69%)	Gaps:	29/883 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKSVLMVAEKPSLAASLAGILSNGRCTAKRGTGNGCSTHEWTGNFRNEGSVHFRMTSVCGHVMSL 65
            ||:|||||||||||.|:|.|||.|..::.:|....||.|::||.|..: .|||:|||||||||:|
Mouse     1 MKTVLMVAEKPSLAQSIAKILSRGNMSSHKGLNGACSVHKYTGTFAGQ-PVHFKMTSVCGHVMTL 64

  Fly    66 DFNKKYNCWDKVDPIQLFGCA-TEKKETNPKQNMRKFLAHEARGCDYLVLWLDCDKEGENICFEV 129
            ||..|||.||||||.:||..| |||||.|||.||.|||..|.|||||:|||||||||||||||||
Mouse    65 DFLGKYNKWDKVDPAELFSQAPTEKKEANPKLNMVKFLQVEGRGCDYVVLWLDCDKEGENICFEV 129

  Fly   130 MDAVKHVINNVYSDQVT-YRAHFSAITEKDIKKAMETLGHPNENEAKSVDARQELDLRIGCAFTR 193
            :|||..|:||.::.:.| :||.||:||:.||..||..|..|:.|||.||||||||||||||||||
Mouse   130 LDAVLPVMNNAHNGEKTVFRARFSSITDTDICNAMTRLSEPDHNEALSVDARQELDLRIGCAFTR 194

  Fly   194 FQTKFFQDRYGDLDSSLISYGPCQTPTLGFCVKRHDDIQTFKPESFWHLQLLA---GQPEVTLEW 255
            ||||:||.:||||||||||:||||||||||||:|||.||:||||::|.||...   .:..:.|:|
Mouse   195 FQTKYFQGKYGDLDSSLISFGPCQTPTLGFCVERHDKIQSFKPETYWVLQAKVHTDKEESLLLDW 259

  Fly   256 ARGRVFKKDIAIMLLNRVKEHKKATVESVASKEAYKSKPQALNTVELMRICSSGLGIGPFQAMQI 320
            .|.|||..:||.|.||..|..|:|.||:.:.||..|.:|.||||||::|:.||.||:||..||||
Mouse   260 DRVRVFDWEIAQMFLNMTKLEKEAWVEATSRKEKAKQRPLALNTVEMLRVASSALGMGPQHAMQI 324

  Fly   321 AERLYTQGYISYPRTETNQYPTNFDLPAVLHVLKPSADFGEEARSILGD-IQTPRKGKDAGDHPP 384
            |||||||||||||||||..||.||||...|........:.:..:.:|.: |..||||.|||||||
Mouse   325 AERLYTQGYISYPRTETTHYPENFDLKGSLRQQANHPYWADSVKQLLAEGINRPRKGHDAGDHPP 389

  Fly   385 ITPMKLGNRSDFDRDTWRVYEFICRHFMGTVSRDLKYRVTTAKLSVGMETFSCTASVLIDAGFTK 449
            |||||....::...|.||:||:|.|||:.|||.|.||..:|....:|.|.|:|....:|..|||:
Mouse   390 ITPMKSATEAELGGDAWRLYEYITRHFIATVSHDCKYLQSTISFRIGPEHFTCMGKTVISPGFTE 454

  Fly   450 VMTWSAFGKDEPQPPFVQGTQVAINDVRLIESQTGPPDYLTESELITLMEEHGIGTDASIPVHIN 514
            :|.|.:...:|..|...:|....:.:|:::|.||.|||||||:|||||||:||||||||||||||
Mouse   455 IMPWQSVPLEESLPTCQKGDTFTVGEVKMLEKQTSPPDYLTEAELITLMEKHGIGTDASIPVHIN 519

  Fly   515 NICQRNYVHIENGRKLMPTTLGIVLVHGYQKIDPELVLPTMRTEVERMLTLIAQGSANFQDVLRH 579
            ||||||||.:|:||:|.||.|||||||||.|||.||||||:|:.||:.|.|||||.|::..||.|
Mouse   520 NICQRNYVTVESGRRLKPTNLGIVLVHGYYKIDAELVLPTIRSAVEKQLNLIAQGKADYHQVLGH 584

  Fly   580 AIKIFKLKFMYFVKNIDSMDALFEVSFSPLAESGKAHSRCGKCRRYMKYIQTKPARLHCSHCDET 644
            .:.|||.||.|||.:|..||.|.||||||||.:||..||||||.|:|||||.||:||||||||||
Mouse   585 TLDIFKRKFHYFVDSIAGMDELMEVSFSPLAATGKPLSRCGKCHRFMKYIQAKPSRLHCSHCDET 649

  Fly   645 YALP-IGNVKVYREFKCPLDDFDLLAFSTGVKGRSYPFCPYCYNHPPFSDMPHLGGCNTCTNANC 708
            |.|| .|.:|:|:|.:||||||:|:.:|:|.:|:|||.||||||||||.||....|||.||:..|
Mouse   650 YTLPQNGTIKLYKELRCPLDDFELVLWSSGSRGKSYPLCPYCYNHPPFRDMKKGMGCNECTHPTC 714

  Fly   709 PHSLNTLGISSCVECPTGVLVLDCTLAPTWKLGCNRCDVIINCFKGATKITVEEAKCQECGAQQV 773
            .|||:.|||..||||..||||||.|..|.||:.||.|:|:.:||:.|.::.|....|..|.|..:
Mouse   715 QHSLSMLGIGQCVECENGVLVLDPTSGPKWKVACNTCNVVAHCFENAHRVRVSADTCNTCEAALL 779

  Fly   774 NVVYKSDKSKFKDGSEEKSGCIFCSADFSHLVEKHRAVASRPVRSGG-GFRGGKAGRGGGGMGGA 837
            :|.:...||.......:.:|||||...|..|||...|.:..|:..|| |.|.|: |||.|.
Mouse   780 DVDFNKAKSPLPGNETQHTGCIFCDPVFQELVELKHAASCHPMHRGGPGRRQGR-GRGRGR---- 839

  Fly   838 AFGSGGAVTAGGGPNAGGGVRGSRVAKDKMGQLASYFV 875
                    ...|.||       .|..||||..||:|||
Mouse   840 --------RPPGKPN-------PRRPKDKMSALAAYFV 862

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Top3beta	NP_001284938.1	PRK07219	4..781	CDD:235971	468/783 (60%)
		TOPRIM_TopoIA_TopoIII	4..166	CDD:173782	104/163 (64%)
		TOP1Ac	171..588	CDD:238110	249/420 (59%)
Top3b	NP_001313505.1	TOPRIM_TopoIA_TopoIII	3..167	CDD:173782	104/164 (63%)
		Topoisom_bac	169..582	CDD:395899	244/412 (59%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	820..855		17/54 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850115
Domainoid	1	1.000	499	1.000	Domainoid score	I350
eggNOG	1	0.900	-	-		E1_COG0550
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2923
Inparanoid	1	1.050	1000	1.000	Inparanoid score	I295
Isobase	1	0.950	-	0.993157	Normalized mean entropy	S1220
OMA	1	1.010	-	-		QHG62408
OrthoDB	1	1.010	-	-		D104272at33208
OrthoFinder	1	1.000	-	-		FOG0000966
OrthoInspector	1	1.000	-	-		oto94104
orthoMCL	1	0.900	-	-		OOG6_103726
Panther	1	1.100	-	-	LDO	PTHR11390
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3324
SonicParanoid	1	1.000	-	-		X3364
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	17	16.750