DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Top3beta and Top3a

DIOPT Version :9

Sequence 1:NP_001284938.1 Gene:Top3beta / 31565 FlyBaseID:FBgn0026015 Length:875 Species:Drosophila melanogaster
Sequence 2:NP_033436.1 Gene:Top3a / 21975 MGIID:1197527 Length:1003 Species:Mus musculus


Alignment Length:950 Identity:302/950 - (31%)
Similarity:421/950 - (44%) Gaps:160/950 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MKSVLMVAEKPSLAASLAGILSNGRCTAKRGTGNGCSTHEWTGNFRNEGSVHFRMTSVCGHVMSL 65
            ::.||.||||...|..:|.:|||||...|.|.......:|:..:...: :|...||||.||:::.
Mouse    33 VRKVLCVAEKNDAAKGIADLLSNGRMRRKEGLSKFNKIYEFDYHLYGQ-NVTMIMTSVSGHLLAH 96

  Fly    66 DFNKKYNCWDKVDPIQLFGCATEKKETNPKQNMRKFLAHEARGCDYLVLWLDCDKEGENICFEVM 130
            ||..::..|...:|:.||....||.......:::|.|..|...|..||:|.|||:|||||.||::
Mouse    97 DFQMQFRKWQSCNPLVLFEAEIEKYCPENFIDIKKTLERETHHCQALVIWTDCDREGENIGFEII 161

  Fly   131 DAVKHVINNVYSDQVTYRAHFSAITEKDIKKAMETLGHPNENEAKSVDARQELDLRIGCAFTRFQ 195
                ||...|..:....||.||.||...::.|.|.|..|::..:.:||.|||||||||.||||||
Mouse   162 ----HVCKAVKPNLRVLRARFSEITPHAVRTACENLTEPDQRVSDAVDVRQELDLRIGAAFTRFQ 222

  Fly   196 TKFFQDRYGD-LDSSLISYGPCQTPTLGFCVKRHDDIQTFKPESFWHLQLLAGQPEVTLE--WAR 257
            |...|..:.: |...|||||.||.|||||.|:|...||.|.||.|..:::.....:.|:|  |.|
Mouse   223 TLRLQRIFPEVLAEQLISYGSCQFPTLGFVVERFKAIQAFVPEVFHKIKVTHDHKDGTVEFNWKR 287

  Fly   258 GRVFKKDIAIMLLNRVKEHKKATVESVASKEAYKSKPQALNTVELMRICSSGLGIGPFQAMQIAE 322
            .|:|.....::|.....|...|||..|.||...|.:||||:||||.::.|..|.|...:.|:|||
Mouse   288 YRLFNHTACLVLYQLCMEDPMATVVEVRSKPKSKWRPQALDTVELEKLASRKLRINAKETMRIAE 352

  Fly   323 RLYTQGYISYPRTETNQYPTNFDLPAVLHVLKPSADFGEEARSIL--GDIQTPRKG-KDAGDHPP 384
            :|||||||||||||||.:|.:.:|.|::........:|..|::||  |. .|||.| |....|||
Mouse   353 KLYTQGYISYPRTETNIFPKDLNLVALVEQQTVDPHWGAFAQTILERGG-PTPRNGSKSDQAHPP 416

  Fly   385 ITPMKLGNRSDFDRDTWRVYEFICRHFMGTVSRDLKYRVTTAKLSVGMETFSCTASVLIDAGFTK 449
            |.|.|.  .|....|..|:||||.|||:...|:|.:.:.||.::.:..|.|.....:::...:..
Mouse   417 IHPTKY--TSGLQGDDRRLYEFIVRHFLACCSQDAQGQETTVEIDIAQERFVAHGLIILARNYLD 479

  Fly   450 VMT---WSAFGKDEPQPPFVQGTQVAINDVRLIESQTGPPDYLTESELITLMEEHGIGTDASIPV 511
            |..   ||    |:..|.:.||:....:.|.:::.:|.||..|||::||.|||:|||||||:...
Mouse   480 VYPYDHWS----DKLLPVYEQGSHFQPSTVEMVDGETSPPQLLTEADLIALMEKHGIGTDATHAE 540

  Fly   512 HINNICQRNYVHIENGRKLMPTTLGIVLVHGYQKIDPELVLPTMRTEVERMLTLIAQGSANFQDV 576
            ||..|..|.||.:.:.::.:|..||:.||.||..:..|:..|.:|.|:|..|.||.:|..:...|
Mouse   541 HIETIKARMYVGLTSDKRFLPGHLGMGLVEGYDSMGYEMSKPDLRAELEADLKLICEGKKDKFQV 605

  Fly   577 LRHAIKIFKLKFMYFVKNIDSMDALFEVSFSPLAESGKAHS----------RCGKCRRYMKYIQT 631
            ||..::.:|..|:..|.....:|...........|..:...          :|.:|.:.| .::|
Mouse   606 LRQQVQKYKQVFIEAVAKAKKLDEALSQYLGERTEMAQQEEIYPAMPEPVRKCPQCNKDM-VLKT 669

  Fly   632 KPA---RLHC---SHCDETYALPIGNVKVYREFKCPLDDFDLLAFSTGVKGRSYPFCPYCYNHP- 689
            |.:   .|.|   ..|......|               |..|.|      .|....|..|...| 
Mouse   670 KKSGGFYLSCMGFPECRSAVWFP---------------DSVLEA------SRDNSVCSVCQPPPV 713

  Fly   690 ----------------PFSDMPHLGGCN-------------TCTNANCP-------HSLNTLGIS 718
                            |...:..:|||:             ....|:.|       .:||.:..|
Mouse   714 YRLKLKFKRGSLPPAMPLEFVGCIGGCDETLKEIFGLRFPRALPRASQPSGHLQASQALNRMDSS 778

  Fly   719 S------CVECPT--GVLVLDCTLAPTWKLGCNRCDVIINCFKGATKITVEEAKCQECGAQQVNV 775
            .      .|...|  ...|....|.||.....|  .|..||.:.|..:||.:.     |..|...
Mouse   779 QHNLSQPLVNRHTRPSKTVAQALLPPTTAGESN--SVTCNCGREAVLLTVRKQ-----GPNQGRH 836

  Fly   776 VYKSDKSKFKDGSEEKSGC-IFCSADFSHLVEKHRAVASRPVRSGGGFRGGKAGRGGGGMG---- 835
            .||.          ....| .|..||.||             .:|||.....:|..|..:|    
Mouse   837 FYKC----------SNGDCNFFLWADSSH-------------STGGGTPTSASGPPGSSVGCPSS 878

  Fly   836 -GA---AFGSGGAVTAGG-----------------GPNAG 854
             |:   .|||.|:.:.||                 |||.|
Mouse   879 VGSHMDGFGSLGSDSDGGTPCLCGQPAVTRTVQKDGPNKG 918

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Top3betaNP_001284938.1 PRK07219 4..781 CDD:235971 279/846 (33%)
TOPRIM_TopoIA_TopoIII 4..166 CDD:173782 59/161 (37%)
TOP1Ac 171..588 CDD:238110 172/425 (40%)
Top3aNP_033436.1 TopA 35..635 CDD:223624 236/611 (39%)
TOPRIM_TopoIA_TopoIII 35..193 CDD:173782 59/162 (36%)
TOP1Ac 202..617 CDD:238110 172/421 (41%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 400..426 13/28 (46%)
YrdD <652..722 CDD:223625 16/91 (18%)
zf-C4_Topoisom 655..694 CDD:279704 9/54 (17%)
zf-GRF 813..854 CDD:284302 14/55 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 856..888 8/31 (26%)
zf-GRF 897..941 CDD:284302 3/21 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 946..991
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0550
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG62408
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000966
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
43.820

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