Protein Alignment Top3beta and top-3

DIOPT Version :9

• Sequence 1: NP_001284938.1
• Gene: Top3beta / 31565
• FlyBaseID: FBgn0026015
• Length: 875
• Species: Drosophila melanogaster
• Sequence 2: NP_499558.1
• Gene: top-3 / 176631
• WormBaseID: WBGene00006596
• Length: 759
• Species: Caenorhabditis elegans
• Alignment Length: 600
• Identity: 220/600 - (36%)
• Similarity: 329/600 - (54%)
• Gaps: 20/600 - (3%)

  Fly     1 MKSVLMVAEKPSLAASLAGILSNGRCTAKRGTGNGCSTHEWTGN---FRNEGSVHFRMTSVCGHV 62
            ||..|.||||..:|..:|.|||||  ||.|..|.......:|.|   |..:.::  .:|||.||:
 Worm     1 MKRALFVAEKNDVAKGVAAILSNG--TANRREGRSKFNKIYTLNTELFGQQTAI--SVTSVSGHM 61

  Fly    63 MSLDFNKKYNCWDKVDPIQLFGCATEKKETNPKQNMRKFLAHEARGCDYLVLWLDCDKEGENICF 127
            |:..|::..:.|.....::||........|...:.:.:.|..:|:..|.||:|.|||:|||.|..
 Worm    62 MNFQFHENMSNWQTASMVELFRAPVRHVVTPEMKLIEQTLREQAQRHDILVVWTDCDREGEAIGA 126

  Fly   128 EVMDAVKHVINNVYSDQVTYRAHFSAITEKDIKKAMETLGHPNENEAKSVDARQELDLRIGCAFT 192
            |::...:.  :|...|  .:||.||.||:..|.:|...|...:|....:||.|.|||||||.|||
 Worm   127 EIVKVCRD--SNRRLD--IFRARFSEITKAAITRAARNLIRLDEKTVAAVDCRSELDLRIGSAFT 187

  Fly   193 RFQTKFFQDRYGDL-----DSSLISYGPCQTPTLGFCVKRHDDIQTFKPESFWHL--QLLAGQPE 250
            |.||...::|:.||     .|.:||||.||.|||||...|:..|:.|..|.||.|  :......:
 Worm   188 RLQTLHLRNRFRDLLGQNDTSQVISYGSCQFPTLGFVTDRYKMIENFVSEPFWKLIVEHTRESHK 252

  Fly   251 VTLEWARGRVFKKDIAIMLLNRVKEHKKATVESVASKEAYKSKPQALNTVELMRICSSGLGIGPF 315
            |...|.|.|:|.:|...:|.:..||.|:|.||.||.|...|.:||||:||||.::..|.|.:...
 Worm   253 VEFLWDRNRLFDRDTVDILHDECKETKEAHVEKVAKKPKSKWRPQALDTVELEKLGISKLRMSAK 317

  Fly   316 QAMQIAERLYTQGYISYPRTETNQYPTNFDLPAVLHVLKPSADFGEEARSILGDIQTPRKGKDAG 380
            |.||:||:||::|:|||||||||::|...:|..::.....|..:|:.|..:|.:...||.|:.:.
 Worm   318 QTMQVAEKLYSKGFISYPRTETNKFPAGLNLTPLVQQQTQSNIWGDFANEVLQNGVNPRNGRKSD 382

  Fly   381 D-HPPITPMKLGNRSDFDRDTWRVYEFICRHFMGTVSRDLKYRVTTAKLSVGMETFSCTASVLID 444
            : ||||.|:|...:.....|.|:|||.:.|||:..||:|.:...|...|:||.|.|..:...:.|
 Worm   383 EAHPPIHPLKFTEKHQLQGDDWKVYELVVRHFLACVSQDAQGEETMVNLTVGTEKFHASGLRIRD 447

  Fly   445 AGFTKVMTWSAFGKDEPQPPFVQGTQVAINDVRLIESQTGPPDYLTESELITLMEEHGIGTDASI 509
            .|:.||..:..:| :...|.:.:|.:....::::.:.:|..||:|||::||:||:::||||||:.
 Worm   448 MGYLKVYVYEKWG-NRLLPTYTEGERFTDFELKIGDGKTQAPDFLTEADLISLMDKYGIGTDATH 511

  Fly   510 PVHINNICQRNYVHIENGRKLMPTTLGIVLVHGYQKIDPELVLPTMRTEVERMLTLIAQGSANFQ 574
            ..||..|..|.|:.:....||:|:.||:.||.||..:...:..|.:|..:|..|..|..|....|
 Worm   512 AEHIEKIKTREYIGVRPDGKLIPSFLGLALVDGYDDMGFAMSKPDLRANLEIGLKEICDGRRQKQ 576

  Fly   575 DVLRHAIKIFKLKFM 589
            :||...|..::..|:
 Worm   577 EVLDEQIGKYRAIFV 591

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Top3beta	NP_001284938.1	PRK07219	4..781	CDD:235971	218/596 (37%)
		TOPRIM_TopoIA_TopoIII	4..166	CDD:173782	54/164 (33%)
		TOP1Ac	171..588	CDD:238110	162/424 (38%)
top-3	NP_499558.1	TopA	5..597	CDD:223624	218/595 (37%)
		TOPRIM_TopoIA_TopoIII	5..161	CDD:173782	54/163 (33%)
		TOP1Ac	166..590	CDD:238110	162/424 (38%)
		zf-GRF	717..759	CDD:284302

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0550
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62408
OrthoDB	1	1.010	-	-		D104272at33208
OrthoFinder	1	1.000	-	-		FOG0000966
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.830