DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Top3beta and top3b

DIOPT Version :9

Sequence 1:	NP_001284938.1	Gene:	Top3beta / 31565	FlyBaseID:	FBgn0026015	Length:	875	Species:	Drosophila melanogaster
Sequence 2:	NP_001182501.1	Gene:	top3b / 100145467	XenbaseID:	XB-GENE-976087	Length:	858	Species:	Xenopus tropicalis

Alignment Length:	886	Identity:	503/886 - (56%)
Similarity:	625/886 - (70%)	Gaps:	39/886 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKSVLMVAEKPSLAASLAGILSNGRCTAKRGTGNGCSTHEWTGNFRNEGSVHFRMTSVCGHVMSL 65
            ||:|||||||||||.|:|.|||.|..::::|....||.||:||:|..: :|.|:|||||||||||
Frog     1 MKTVLMVAEKPSLAQSIAKILSRGSASSRKGLNGACSVHEYTGSFMGQ-TVRFKMTSVCGHVMSL 64

  Fly    66 DFNKKYNCWDKVDPIQLFGCA-TEKKETNPKQNMRKFLAHEARGCDYLVLWLDCDKEGENICFEV 129
            ||..|||.||||||.:||..| |||||.|||.:|.|||..|.|||||:|||||||||||||||||
Frog    65 DFIGKYNNWDKVDPAELFSKAPTEKKEANPKLSMVKFLQVEGRGCDYVVLWLDCDKEGENICFEV 129

  Fly   130 MDAVKHVINNVY-SDQVTYRAHFSAITEKDIKKAMETLGHPNENEAKSVDARQELDLRIGCAFTR 193
            :||:..|:|..: .::..|||.||:||:.||..||..||.||:|||.||||||||||||||||||
Frog   130 LDAIHPVMNRAHGGERTVYRAKFSSITDTDILNAMNRLGEPNKNEALSVDARQELDLRIGCAFTR 194

  Fly   194 FQTKFFQDRYGDLDSSLISYGPCQTPTLGFCVKRHDDIQTFKPESFWHLQLLAGQPE---VTLEW 255
            ||||:||.:||:|||||||:||||||||||||:|||.||:||||::|.||:...:.:   :.|:|
Frog   195 FQTKYFQGKYGNLDSSLISFGPCQTPTLGFCVERHDKIQSFKPETYWVLQVKVSRGQENPLILDW 259

  Fly   256 ARGRVFKKDIAIMLLNRVKEHKKATVESVASKEAYKSKPQALNTVELMRICSSGLGIGPFQAMQI 320
            .|.|||.::||.|.:|..|..|:|.||||:.||..|.:||||||||::|:.||.||:||...|||
Frog   260 DRVRVFDREIAQMFINITKTAKEAQVESVSKKEKAKQRPQALNTVEMLRVASSALGMGPQHTMQI 324

  Fly   321 AERLYTQGYISYPRTETNQYPTNFDLPAVLHVLKPSADFGEEARSILGD-IQTPRKGKDAGDHPP 384
            |||||||||||||||||..||.||||...|.....:..:.:..:::|.: |..||||.|||||||
Frog   325 AERLYTQGYISYPRTETTHYPENFDLKGTLRQQANNPFWADMVKTLLAEGINRPRKGTDAGDHPP 389

  Fly   385 ITPMKLGNRSDFDRDTWRVYEFICRHFMGTVSRDLKYRVTTAKLSVGMETFSCTASVLIDAGFTK 449
            ||||:....::...|.||:||:|.|||:.|:|.|.||..|:...|||.|.|:.|...:|..|||:
Frog   390 ITPMRSATEAELGGDAWRLYEYITRHFIATISHDCKYLQTSIAFSVGPEKFTTTCKEVISPGFTE 454

  Fly   450 VMTWSAFGKDEPQPPFVQGTQVAINDVRLIESQTGPPDYLTESELITLMEEHGIGTDASIPVHIN 514
            :|.|....|:|...|..:|.:.::::::|:|.||.|||||||:|||:|||.||||||||||||||
Frog   455 IMPWQGIPKEESFQPCERGDKFSVDEMKLMEKQTCPPDYLTEAELISLMERHGIGTDASIPVHIN 519

  Fly   515 NICQRNYVHIENGRKLMPTTLGIVLVHGYQKIDPELVLPTMRTEVERMLTLIAQGSANFQDVLRH 579
            ||||||||.:|:||:|.||:|||||||||.||||||||||:|:.||:.|.|||||.||||.||.|
Frog   520 NICQRNYVTVESGRRLKPTSLGIVLVHGYYKIDPELVLPTIRSAVEKQLNLIAQGKANFQQVLDH 584

  Fly   580 AIKIFKLKFMYFVKNIDSMDALFEVSFSPLAESGKAHSRCGKCRRYMKYIQTKPARLHCSHCDET 644
            .:.|||.||.|||.:|..||.|.||||||||.:||..||||||.|:|||||.||:||||||||||
Frog   585 TLDIFKRKFHYFVDSIAGMDELMEVSFSPLAATGKPLSRCGKCHRFMKYIQAKPSRLHCSHCDET 649

  Fly   645 YALP-IGNVKVYREFKCPLDDFDLLAFSTGVKGRSYPFCPYCYNHPPFSDMPHLGGCNTCTNANC 708
            |:|| .|.:|:|:|.:||||||:|:.:|:|.:|:|||.|||||||.||.||....|||.||:..|
Frog   650 YSLPQNGTIKLYKELRCPLDDFELVLWSSGSRGKSYPLCPYCYNHAPFRDMKKGMGCNECTHPTC 714

  Fly   709 PHSLNTLGISSCVECPTGVLVLDCTLAPTWKLGCNRCDVIINCFKGATKITVEEAKCQECGAQQV 773
            .|||:.|||:.||||.:||:|||.|..|.||:.||:|:||::.|:.|.::.|....|..|.|..|
Frog   715 QHSLSMLGIAQCVECESGVMVLDSTSGPKWKMSCNKCNVIVHFFENAHRVRVSAETCDACDAAVV 779

  Fly   774 NVVYKSDKSKFKDGSEEKSGCIFCSADFSHLVEKHRAVASRPVRSGGGFRGGKAGRGGGGMGGAA 838
            :|.:...|........:.:||:||...|..|||...|....|:..||  :|.:.|||.|
Frog   780 HVDFNKAKCPLPADQTQHAGCVFCDPVFQDLVELKHATMKHPMHKGG--QGRRQGRGRG------ 836

  Fly   839 FGSGGAVTAGGGPNAGGGVRGSRV----AKDKMGQLASYFV 875
                               ||.|.    .||||..||:|||
Frog   837 -------------------RGRRANPKKPKDKMAALAAYFV 858

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Top3beta	NP_001284938.1	PRK07219	4..781	CDD:235971	471/783 (60%)
		TOPRIM_TopoIA_TopoIII	4..166	CDD:173782	102/163 (63%)
		TOP1Ac	171..588	CDD:238110	253/420 (60%)
top3b	NP_001182501.1	TOPRIM_TopoIA_TopoIII	3..167	CDD:173782	102/164 (62%)
top3b	NP_001182501.1	Topoisom_bac	169..583	CDD:376463	250/413 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	512	1.000	Domainoid score	I322
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2923
Inparanoid	1	1.050	1010	1.000	Inparanoid score	I292
OMA	1	1.010	-	-		QHG62408
OrthoDB	1	1.010	-	-		D104272at33208
OrthoFinder	1	1.000	-	-		FOG0000966
OrthoInspector	1	1.000	-	-		oto104312
Panther	1	1.100	-	-	LDO	PTHR11390
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3364
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	12.080