DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Top3beta and top3a

DIOPT Version :9

Sequence 1:NP_001284938.1 Gene:Top3beta / 31565 FlyBaseID:FBgn0026015 Length:875 Species:Drosophila melanogaster
Sequence 2:XP_004918127.2 Gene:top3a / 100135734 XenbaseID:XB-GENE-1003600 Length:1021 Species:Xenopus tropicalis


Alignment Length:1012 Identity:295/1012 - (29%)
Similarity:436/1012 - (43%) Gaps:192/1012 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MKSVLMVAEKPSLAASLAGILSNGRCTAKRGTGNGCSTHEWTGNFRNEGSVHFRMTSVCGHVMSL 65
            :..||.||||...|..:|.::||.|...:.|.......:|:..:...: .|...||||.||:::|
 Frog    38 VNKVLCVAEKNDAAKGIADLMSNSRMRRREGFSKFNKIYEYEYHLFGK-DVTVVMTSVSGHLLAL 101

  Fly    66 DFNKKYNCWDKVDPIQLFGCATEKKETNPKQNMRKFLAHEARGCDYLVLWLDCDKEGENICFEVM 130
            ||......|...:|:.||....:|...:...|:::.|..|.|.|..|::|.|||:|||||.||::
 Frog   102 DFQDHMKKWHSCNPVSLFEAEVQKYCPDDFVNIKRTLEREVRQCQALIIWTDCDREGENIGFEII 166

  Fly   131 DAVKHVINNVYSDQVTYRAHFSAITEKDIKKAMETLGHPNENEAKSVDARQELDLRIGCAFTRFQ 195
                ||..:|..:...:||.||.||.:.|:.|.|.|..|::|.:.:||.|.|||||||.||||||
 Frog   167 ----HVCKSVKPNLQVFRARFSEITPRSIRMACEHLVQPDQNISDAVDVRMELDLRIGAAFTRFQ 227

  Fly   196 TKFFQDRYGD-LDSSLISYGPCQTPTLGFCVKRHDDIQTFKPESFWHLQLLAGQPE--VTLEWAR 257
            |...|..:.. |.:.|||||.||.|||||.|:|...||.|.||:|:.:::.....:  |...|.|
 Frog   228 TLRLQKMFPSVLSNQLISYGSCQFPTLGFVVERFKAIQAFIPETFYKIKVTHEHEDGLVEFSWKR 292

  Fly   258 GRVFKKDIAIMLLNRVKEHKKATVESVASKEAYKSKPQALNTVELMRICSSGLGIGPFQAMQIAE 322
            .|:|.....::|.....|...|||..|.||...|.:|.||:||||.::.|..|.||..:.|::||
 Frog   293 NRLFNHTACLVLYQICMEDPMATVMEVGSKPKSKWRPVALDTVELEKLASRKLKIGAKETMKVAE 357

  Fly   323 RLYTQGYISYPRTETNQYPTNFDLPAVLHVLKPSADFGEEARSIL--GDIQTPRKG-KDAGDHPP 384
            :|||||:|||||||||.:|.:.:|.:::........:|..|:.||  |. .|||.| |....|||
 Frog   358 KLYTQGFISYPRTETNIFPKDLNLTSLVEQQTHDHQWGGFAQRILERGG-PTPRNGNKTDQAHPP 421

  Fly   385 ITPMKLGNRSDFDRDTWRVYEFICRHFMGTVSRDLKYRVTTAKLSVGMETFSCTASVLIDAGFTK 449
            |.|.|..|  ....:..|:||||.|||:...|:|.:.:.||.::.:..|.|.....::|...:..
 Frog   422 IHPTKYTN--SLQGNEQRIYEFIVRHFLACCSQDAQGQETTVEIDIAAERFVAHGLMIIARNYLD 484

  Fly   450 VMTWSAFGKDEPQPPFVQGTQVAINDVRLIESQTGPPDYLTESELITLMEEHGIGTDASIPVHIN 514
            |..:..: ..:..|.:..||:...:.|.:::.:|.||..|||::||:|||:|||||||:...||.
 Frog   485 VYPYDKW-NTKIIPVYEMGTRFQPSTVEMVDGETSPPQLLTEADLISLMEKHGIGTDATHAEHIE 548

  Fly   515 NICQRNYVHIENGRKLMPTTLGIVLVHGYQKIDPELVLPTMRTEVERMLTLIAQGSANFQDVLRH 579
            .|..|.||.:...::.:|..||:.||.||..:..|:..|.:|.|:|..|.||.:|..:...|||.
 Frog   549 TIKSRMYVGLTPEQRFLPGELGMGLVEGYDSMGFEMSKPDLRAELESDLKLICEGKKDKFSVLRL 613

  Fly   580 AIKIFKLKFMYFVKNIDSMDALFEVSFSPLAESGKAHSRCGKCRRYMKYIQTKPARLHCSHCDET 644
            .::.:|..|:........:|......|...|                   |..|.       :|.
 Frog   614 QVQKYKQVFVEAAAKATKLDEALSQYFGQAA-------------------QPVPQ-------EEI 652

  Fly   645 YA---LPIGNVKVYREFKCPLDDFDLLAFS----------TGVKG---------------RSYPF 681
            ||   ||:.        |||..:.|::..:          .|..|               |....
 Frog   653 YADTPLPVR--------KCPQCNKDMVLKTKRDGGFFLSCVGYPGCKSSVWFPSFVLEVSRDESI 709

  Fly   682 CPYCYNHPPFS---------------------------------DMPHLGGCNTCTNANCPHSLN 713
            |..|..||.:.                                 |:.:|.|.|....| .|...|
 Frog   710 CGTCKPHPVYKLKMKFKRGSVPPLMPLEFVGCIGGCDETLREILDLKYLHGGNRAPQA-APRESN 773

  Fly   714 TLGI-------------------SSCVECPTGVLVLDCTLAPTWKLGCNRCDVIINCFKGATKIT 759
            .|.:                   :..::.|.........:||| .......:|:.||...|.::|
 Frog   774 HLQVNQTSNRMGNSGDGRGRQPQAKTLKPPVAKPSASRGVAPT-PSSSESNEVVCNCGVAAVQLT 837

  Fly   760 V-EEAKCQ-----ECGAQQVNVVYKSDKS---------------------------KFK------ 785
            | :|...|     :|.....|....:|::                           .|:      
 Frog   838 VRKEGPNQGRPFYKCNGGACNFFLWADQADSGSPNAQGGHTTGRPSNAFSNPRASDSFRPAGGGS 902

  Fly   786 -DGSEEKSGCIFCSADFSHLVEKHRA-------VASRPVRSGGGF--------RGGKAGRGGGGM 834
             .|||.::.|:......:..|:|..|       ..|:|.....||        ....:....|..
 Frog   903 EPGSEGQAVCMCNQPAVTRTVQKDGANKGRQFHTCSKPREQQCGFFQWADENVPPASSSEFSGSF 967

  Fly   835 GGAAFGSGGAVTAGGGPNAGGGVRGSRVAKDKMGQLA 871
            ||::| |||:    |.|. |.|.:..|......|.:|
 Frog   968 GGSSF-SGGS----GAPR-GFGKKNKRSESSFSGPVA 998

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Top3betaNP_001284938.1 PRK07219 4..781 CDD:235971 268/868 (31%)
TOPRIM_TopoIA_TopoIII 4..166 CDD:173782 57/161 (35%)
TOP1Ac 171..588 CDD:238110 165/422 (39%)
top3aXP_004918127.2 TOPRIM_TopoIA_TopoIII 40..198 CDD:173782 57/162 (35%)
TOP1Ac 204..622 CDD:238110 165/421 (39%)
YrdD 660..773 CDD:223625 17/121 (14%)
zf-C4_Topoisom 660..698 CDD:307520 6/45 (13%)
zf-GRF 825..864 CDD:399670 10/38 (26%)
zf-GRF 912..954 CDD:399670 8/41 (20%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG62408
OrthoDB 1 1.010 - - D104272at33208
OrthoFinder 1 1.000 - - FOG0000966
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
43.930

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