Protein Alignment Ppp2r1b and Pp2A-29B

DIOPT Version :10

• Sequence 1: XP_017451115.3
• Gene: Ppp2r1b / 315648
• RGDID: 1304764
• Length: 694
• Species: Rattus norvegicus
• Sequence 2: NP_001245944.1
• Gene: Pp2A-29B / 2768940
• FlyBaseID: FBgn0260439
• Length: 650
• Species: Drosophila melanogaster
• Alignment Length: 638
• Identity: 431/638 - (67%)
• Similarity: 505/638 - (79%)
• Gaps: 24/638 - (3%)

  Rat    19 DDSLYPIAVLIDELRNEDVQLRLNSIKKLSTIALALGVERTRTELLPFLTDTIYDEDEVLLALAE 83
            ||||||||||||||:||||||||||||||||||||||.||||:||:||||:|||||||||||||:
  Fly     9 DDSLYPIAVLIDELKNEDVQLRLNSIKKLSTIALALGEERTRSELIPFLTETIYDEDEVLLALAD 73

  Rat    84 QLGNFTGLVGGPDFAHCLLPPLESLATVEETVVRDKAVESLRQISQEHTPVALEAHFVPLVKRLA 148
            ||||||.|||||:||..|:|||||||||||||||||||||||.::.||:...||.|.||.::||.
  Fly    74 QLGNFTSLVGGPEFAMYLIPPLESLATVEETVVRDKAVESLRTVAAEHSAQDLEIHVVPTLQRLV 138

  Rat   149 SGDWFTSRTSACGLFSVCYPRASNAVKAEIRQHFRSLCSDDTPMVRRAAASKLGEFAKVLELDSV 213
            |||||||||||||||||||||.:..||||:|.:||.||.|:|||||||||:||||||||:|.:.:
  Fly   139 SGDWFTSRTSACGLFSVCYPRVTQPVKAELRANFRKLCQDETPMVRRAAANKLGEFAKVVETEYL 203

  Rat   214 KTEIVPLFTNLASDEQDSVRLLAVEACVSIAQLLSQDDLEALVMPTLRQAAEDKSWRVRYMVADK 278
            |::::|.|..||.|:|||||||||||||||||||.|||:|.||:|||||.|.|.|||||||||:|
  Fly   204 KSDLIPNFVQLAQDDQDSVRLLAVEACVSIAQLLPQDDVEHLVLPTLRQCASDSSWRVRYMVAEK 268

  Rat   279 FSELQKAVGPKIALSDLIPAFQSLLRDCEAEVRAAAAHKVRELCENLPTEGRETVIMNQILPYIK 343
            |.:|||||||:|...||:||||.||:|.|||||||.|.||::.|.||....:..:|::.||||::
  Fly   269 FVDLQKAVGPEITRVDLVPAFQYLLKDAEAEVRAAVATKVKDFCANLDKVNQVQIILSSILPYVR 333

  Rat   344 ELVSDTNQHVKSALASVIMGLSTVLGKENTIEHLLPLFLAQLKDECPEVRLNIISNLDCVNEVIG 408
            :||||.|.||||||||||||||.:||...|:|.||||||.|||||||||||||||||||||:|||
  Fly   334 DLVSDPNPHVKSALASVIMGLSPMLGAYQTVEQLLPLFLIQLKDECPEVRLNIISNLDCVNDVIG 398

  Rat   409 IRQLSQSLLPAIVELAEDAKWRVRLAIIEYMPLLAGQLGVEFFDEKLNSLCMAWLVDHVYAIREA 473
            |:||||||||||||||||:|||||||||||||.||||||.||||:||..|||.||.|||||||||
  Fly   399 IQQLSQSLLPAIVELAEDSKWRVRLAIIEYMPALAGQLGQEFFDQKLRGLCMGWLNDHVYAIREA 463

  Rat   474 ATNNLMKLVQKFGTEWAQNTIVPKVLVMANDPNYLHRMTTLFCINALSEACGKEITTKQMLPIVL 538
            ||.|:.|||::||..||:..|:|.:|||:.:.|||||||.|||:|.|:|.||.:||||.:||.||
  Fly   464 ATLNMKKLVEQFGAPWAEQAIIPMILVMSRNKNYLHRMTCLFCLNVLAEVCGTDITTKLLLPTVL 528

  Rat   539 KMAGDQVANVRFNVAKSLQKIGPILDTNALQGEVKPVLQKLGQDEDMDVKYFAQEAISVVAQRLR 603
            .:|.|.||||||||||:||||.|.|:.:.:..:|||.|.||..|.|:|||:||.:||:.:|..:.
  Fly   529 LLAADPVANVRFNVAKTLQKISPFLEASVIDAQVKPTLDKLNTDTDVDVKHFAAQAIAGIAAEME 593

  Rat   604 --------------KLDFPVKDS----EEPSTPGVDKNFFLRPRVPGEDTGKA 638
                          |:: ...||    |.|..|....|..|:     |..|||
  Fly   594 LNVFRTAIPPCMGAKIE-AAMDSKLIVEPPRQPEAADNDILQ-----EMNGKA 640

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ppp2r1b	XP_017451115.3	None
Pp2A-29B	NP_001245944.1	HEAT repeat	15..39	CDD:293787	22/23 (96%)
		HEAT repeat	53..80	CDD:293787	23/26 (88%)
		HEAT repeat	90..120	CDD:293787	24/29 (83%)
		HEAT repeat	129..154	CDD:293787	19/24 (79%)
		HEAT repeat	165..194	CDD:293787	21/28 (75%)
		HEAT_2	175..267	CDD:433376	67/91 (74%)
		HEAT repeat	206..232	CDD:293787	17/25 (68%)
		HEAT repeat	247..271	CDD:293787	18/23 (78%)
		HEAT repeat	285..313	CDD:293787	18/27 (67%)
		HEAT	<327..427	CDD:441023	82/99 (83%)
		HEAT repeat	327..357	CDD:293787	23/29 (79%)
		HEAT repeat	366..392	CDD:293787	23/25 (92%)
		HEAT repeat	403..432	CDD:293787	27/28 (96%)
		HEAT repeat	444..470	CDD:293787	19/25 (76%)
		HEAT repeat	481..510	CDD:293787	16/28 (57%)
		HEAT repeat	520..546	CDD:293787	18/25 (72%)