DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment HMGCR and HMG1

DIOPT Version :10

Sequence 1:XP_011541659.1 Gene:HMGCR / 3156 HGNCID:5006 Length:908 Species:Homo sapiens
Sequence 2:NP_013636.1 Gene:HMG1 / 854900 SGDID:S000004540 Length:1054 Species:Saccharomyces cerevisiae


Alignment Length:940 Identity:359/940 - (38%)
Similarity:503/940 - (53%) Gaps:171/940 - (18%)


- Green bases have known domain annotations that are detailed below.


Human    73 FEEDVLSSD--IIILTITRCIAILY-IYFQFQNLRQLGSKYILGIAGLFTIFSSFVFSTVVIH-F 133
            |.|:|..:|  .:::.:|..:.:.| |:..|.::|:.||.:.|..:.:....||...:..|.. .
Yeast   178 FSENVTQADPFDVLIMVTAYLMMFYTIFGLFNDMRKTGSNFWLSASTVVNSASSLFLALYVTQCI 242

Human   134 LDKELTGLN--EALPFFLLLIDLSRASTLAKFALSSNSQ---------DEVRENIARGMAILGPT 187
            |.||::.|.  |.|||.::::.......:|::||....:         ||:   :...::..|..
Yeast   243 LGKEVSALTLFEGLPFIVVVVGFKHKIKIAQYALEKFERVGLSKRITTDEI---VFESVSEEGGR 304

Human   188 FTLDALVECLVIGVGTMSGVRQLEIMCCFGCMSVLANYFVFM---TFFPACVSLVLELSRESREG 249
            ...|.|: |:...:|......||:.:..|..:|.....|..:   ||:.|.::|.||::      
Yeast   305 LIQDHLL-CIFAFIGCSMYAHQLKTLTNFCILSAFILIFELILTPTFYSAILALRLEMN------ 362

Human   250 RPIWQLSHFARVLEE--EENKPNPVTQR------------------VKMIMSLGLVLVHAH---- 290
                 :.|.:.::::  ||:...|.|.|                  |.:||.|.::|:...    
Yeast   363 -----VIHRSTIIKQTLEEDGVVPSTARIISKAEKKSVSSFLNLSVVVIIMKLSVILLFVFINFY 422

Human   291 ---SRWIADPSPQNST-ADTSKVSL------GLDENVS-------------------KRIEP--- 323
               :.|:.|..  ||. .|..:|||      ...||..                   :|||.   
Yeast   423 NFGANWVNDAF--NSLYFDKERVSLPDFITSNASENFKEQAIVSVTPLLYYKPIKSYQRIEDMVL 485

Human   324 ------SVSLWQFYLSKMISMDIEQVITLSLALLLAVK----YIFFEQTETEST-LSLKNPI--- 374
                  ||::...::||::...:.....:::.||.|.:    |...:..:||.| .|...|:   
Yeast   486 LLLRNVSVAIRDRFVSKLVLSALVCSAVINVYLLNAARIHTSYTADQLVKTEVTKKSFTAPVQKA 550

Human   375 TSPVVTQKKVPDNCCRREPMLVRNNQKCDSVEEETGINRERKVEVIKPLVAETDTPNRATFVVGN 439
            ::||:|.|.|...                           .||:.:....:.:..|:       :
Yeast   551 STPVLTNKTVISG---------------------------SKVKSLSSAQSSSSGPS-------S 581

Human   440 SSLLDTSSVLVTQEPEIE-LPREPRPNEECLQILGNAEKGAKFLSDAEIIQLVNAKHIPAYKLET 503
            ||..|.|.       :|| |.::.||.||...:|.:.  ..|.|.:.|:..||....:|.|.||.
Yeast   582 SSEEDDSR-------DIESLDKKIRPLEELEALLSSG--NTKQLKNKEVAALVIHGKLPLYALEK 637

Human   504 LMETHERGVSIRRQLLSKKLSEP-SSLQYLPYRDYNYSLVMGACCENVIGYMPIPVGVAGPLCLD 567
            .:....|.|::||:.||.....| .:...|||::|:|..|.||||||||||||:||||.|||.:|
Yeast   638 KLGDTTRAVAVRRKALSILAEAPVLASDRLPYKNYDYDRVFGACCENVIGYMPLPVGVIGPLVID 702

Human   568 EKEFQVPMATTEGCLVASTNRGCRAIGLGGGASSRVLADGMTRGPVVRLPRACDSAEVKAWLETS 632
            ...:.:||||||||||||..|||:||..||||::.:..||||||||||.|....|...|.||::.
Yeast   703 GTSYHIPMATTEGCLVASAMRGCKAINAGGGATTVLTKDGMTRGPVVRFPTLKRSGACKIWLDSE 767

Human   633 EGFAVIKEAFDSTSRFARLQKLHTSIAGRNLYIRFQSRSGDAMGMNMISKGTEKALSKL-HEY-F 695
            ||...||:||:|||||||||.:.|.:||..|::||::.:||||||||||||.|.:|.:: .|| :
Yeast   768 EGQNAIKKAFNSTSRFARLQHIQTCLAGDLLFMRFRTTTGDAMGMNMISKGVEYSLKQMVEEYGW 832

Human   696 PEMQILAVSGNYCTDKKPAAINWIEGRGKSVVCEAVIPAKVVREVLKTTTEAMIEVNINKNLVGS 760
            .:|::::|||||||||||||||||||||||||.||.||..|||:|||:...|::|:||.||||||
Yeast   833 EDMEVVSVSGNYCTDKKPAAINWIEGRGKSVVAEATIPGDVVRKVLKSDVSALVELNIAKNLVGS 897

Human   761 AMAGSIGGYNAHAANIVTAIYIACGQDAAQNVGSSNCITLM-EASGPTNEDLYISCTMPSIEIGT 824
            |||||:||:||||||:|||:::|.|||.||||.|||||||| |..|    ||.||.:|||||:||
Yeast   898 AMAGSVGGFNAHAANLVTAVFLALGQDPAQNVESSNCITLMKEVDG----DLRISVSMPSIEVGT 958

Human   825 VGGGTNLLPQQACLQMLGVQGACKDNPGENARQLARIVCGTVMAGELSLMAALAAGHLVKSHMIH 889
            :||||.|.||.|.|.:|||:|.....||.|||||||||...|:||||||.|||||||||:|||.|
Yeast   959 IGGGTVLEPQGAMLDLLGVRGPHATAPGTNARQLARIVACAVLAGELSLCAALAAGHLVQSHMTH 1023

Human   890 NR-------------SKIN-LQDLQGACTK 905
            ||             :.|| |:|....|.|
Yeast  1024 NRKPAEPTKPNNLDATDINRLKDGSVTCIK 1053

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HMGCRXP_011541659.1 2A060605 21..908 CDD:273339 359/940 (38%)
HMG1NP_013636.1 HPIH 10..161 CDD:404239
2A060605 189..1025 CDD:273339 347/899 (39%)
HMG_CoA_R_NADP 616..1025 CDD:129624 249/412 (60%)
Blue background indicates that the domain is not in the aligned region.

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