Protein Alignment HMGCR and HMG2

DIOPT Version :10

• Sequence 1: XP_011541659.1
• Gene: HMGCR / 3156
• HGNCID: 5006
• Length: 908
• Species: Homo sapiens
• Sequence 2: NP_013555.1
• Gene: HMG2 / 851171
• SGDID: S000004442
• Length: 1045
• Species: Saccharomyces cerevisiae
• Alignment Length: 909
• Identity: 340/909 - (37%)
• Similarity: 485/909 - (53%)
• Gaps: 140/909 - (15%)

Human    69 ECPKFEEDVLSSDIIILTITRCIAILYIYFQFQNLRQLGSKYILGIAGLFTIFSSFVFSTVVIHF 133
            |..:|:..::.:..:.|..|.|..       |.::|::|||:.|..:.|.....:...|....|.
Yeast   183 EFDQFDLFIILAAYLTLFYTLCCL-------FNDMRKIGSKFWLSFSALSNSACALYLSLYTTHS 240

Human   134 LDKE---LTGLNEALPFFLLLIDLSRASTLAKFALSSNSQDEVRENIARGMAILGPTFTLDA-LV 194
            |.|:   |..|...|||.:::|.......||.|:|....:..:.:.|.....|....|...| |:
Yeast   241 LLKKPASLLSLVIGLPFIVVIIGFKHKVRLAAFSLQKFHRISIDKKITVSNIIYEAMFQEGAYLI 305

Human   195 ECLVIGVGTMSG----VRQLEIM---CCFGCMSVLANYFVFMTFFPACVSLVLELS--------R 244
            ...:..:.:..|    .|.|..:   |......::.:..:..||:.|.:|:.||::        |
Yeast   306 RDYLFYISSFIGCAIYARHLPGLVNFCILSTFMLVFDLLLSATFYSAILSMKLEINIIHRSTVIR 370

Human   245 ESREGRPIWQLSHFARVLEEEENKPNPVTQRVKMIMSLG-------LVLVHAHSRWIADPSPQNS 302
            ::.|...:  :...|.::.::|....|...|..:.:.||       |:|::.:    ......|:
Yeast   371 QTLEEDGV--VPTTADIIYKDETASEPHFLRSNVAIILGKASVIGLLLLINLY----VFTDKLNA 429

Human   303 TA------DTSKVSL---------GLDENVSKRIEPSVSLWQFY--------------------- 331
            |.      |::..||         |   |:|.::..||...|:|
Yeast   430 TILNTVYFDSTIYSLPNFINYKDIG---NLSNQVIISVLPKQYYTPLKKYHQIEDSVLLIIDSVS 491

Human   332 -------LSKMISMDIEQVITLSLALLLAVK----YIFFEQTETESTLSLKNPITSPVVTQKKVP 385
                   :||::.......|::::.||.|.|    |:.|:..        .|.|...||.||..
Yeast   492 NAIRDQFISKLLFFAFAVSISINVYLLNAAKIHTGYMNFQPQ--------SNKIDDLVVQQKSA- 547

Human   386 DNCCRREPMLVRNNQKCDSVEEETGINRERKVEVIKPLVAETDTPNRATFVVGNSSLLDTSSVLV 450
                              ::|    .:..|.:    |..:..:||..|..::.:..:.:...|..
Yeast   548 ------------------TIE----FSETRSM----PASSGLETPVTAKDIIISEEIQNNECVYA 586

Human   451 TQEPEIELPREP-RPNEECLQILGNAEKGAKFLSDAEIIQLVNAKHIPAYKLETLMETHERGVSI 514
            ....:     || ||....::::  .::..|.:::.|:..||....:|.|.||..:|...|.|.:
Yeast   587 LSSQD-----EPIRPLSNLVELM--EKEQLKNMNNTEVSNLVVNGKLPLYSLEKKLEDTTRAVLV 644

Human   515 RRQLLSKKLSEPSSL-QYLPYRDYNYSLVMGACCENVIGYMPIPVGVAGPLCLDEKEFQVPMATT 578
            ||:.||.....|..: :.||:|:|:|..|.|||||||||||||||||.|||.:|...:.:|||||
Yeast   645 RRKALSTLAESPILVSEKLPFRNYDYDRVFGACCENVIGYMPIPVGVIGPLIIDGTSYHIPMATT 709

Human   579 EGCLVASTNRGCRAIGLGGGASSRVLADGMTRGPVVRLPRACDSAEVKAWLETSEGFAVIKEAFD 643
            |||||||..|||:||..||||::.:..||||||||||.|....|...|.||::.||...||:||:
Yeast   710 EGCLVASAMRGCKAINAGGGATTVLTKDGMTRGPVVRFPTLIRSGACKIWLDSEEGQNSIKKAFN 774

Human   644 STSRFARLQKLHTSIAGRNLYIRFQSRSGDAMGMNMISKGTEKALSKL-HEY-FPEMQILAVSGN 706
            |||||||||.:.|.:||..|::||::.:||||||||||||.|.:|.:: .|| :.:|::::||||
Yeast   775 STSRFARLQHIQTCLAGDLLFMRFRTTTGDAMGMNMISKGVEYSLKQMVEEYGWEDMEVVSVSGN 839

Human   707 YCTDKKPAAINWIEGRGKSVVCEAVIPAKVVREVLKTTTEAMIEVNINKNLVGSAMAGSIGGYNA 771
            |||||||||||||||||||||.||.||..||:.|||:...|::|:||:|||||||||||:||:||
Yeast   840 YCTDKKPAAINWIEGRGKSVVAEATIPGDVVKSVLKSDVSALVELNISKNLVGSAMAGSVGGFNA 904

Human   772 HAANIVTAIYIACGQDAAQNVGSSNCITLM-EASGPTNEDLYISCTMPSIEIGTVGGGTNLLPQQ 835
            ||||:|||:::|.|||.||||.|||||||| |..|    ||.||.:|||||:||:||||.|.||.
Yeast   905 HAANLVTALFLALGQDPAQNVESSNCITLMKEVDG----DLRISVSMPSIEVGTIGGGTVLEPQG 965

Human   836 ACLQMLGVQGACKDNPGENARQLARIVCGTVMAGELSLMAALAAGHLVKSHMIHNRSKINLQDL 899
            |.|.:|||:|.....||.||||||||:...|:||||||.:||||||||:|||.|||......:|
Yeast   966 AMLDLLGVRGPHPTEPGANARQLARIIACAVLAGELSLCSALAAGHLVQSHMTHNRKTNKANEL 1029

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HMGCR	XP_011541659.1	2A060605	21..908	CDD:273339	340/909 (37%)
HMG2	NP_013555.1	HPIH	10..159	CDD:404239
		2A060605	195..1030	CDD:273339	338/897 (38%)
		HMG_CoA_R_NADP	612..1021	CDD:129624	247/412 (60%)