Protein Alignment HMGCR and hmgcra

DIOPT Version :10

• Sequence 1: XP_011541659.1
• Gene: HMGCR / 3156
• HGNCID: 5006
• Length: 908
• Species: Homo sapiens
• Sequence 2: XP_073806595.1
• Gene: hmgcra / 559054
• ZFINID: ZDB-GENE-040401-2
• Length: 911
• Species: Danio rerio
• Alignment Length: 917
• Identity: 697/917 - (76%)
• Similarity: 776/917 - (84%)
• Gaps: 35/917 - (3%)

Human    21 MLSRLFRMHGLFVASHPWEVIVGTVTLTICMMSMNMFTGNNKICGWNYECPKFEEDVLSSDIIIL 85
            ||:||||:||||||||||||||.||||||||||||||||||:|||||::|||.:|.:||||||||
Zfish     1 MLTRLFRIHGLFVASHPWEVIVATVTLTICMMSMNMFTGNNQICGWNFDCPKLDEQILSSDIIIL 65

Human    86 TITRCIAILYIYFQFQNLRQLGSKYILGIAGLFTIFSSFVFSTVVIHFLDKELTGLNEALPFFLL 150
            ||||||||:||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish    66 TITRCIAIVYIYFQFQNLRQLGSKYILGIAGLFTIFSSFVFSTVVIHFLDKELTGLNEALPFFLL 130

Human   151 LIDLSRASTLAKFALSSNSQDEVRENIARGMAILGPTFTLDALVECLVIGVGTMSGVRQLEIMCC 215
            |||||:|..|||||||||||||||||||:|||:||||||||||||||||||||||||||||||||
Zfish   131 LIDLSKACALAKFALSSNSQDEVRENIAKGMAVLGPTFTLDALVECLVIGVGTMSGVRQLEIMCC 195

Human   216 FGCMSVLANYFVFMTFFPACVSLVLELSRESREGRPIWQLSHFARVLEEEE-NKPNPVTQRVKMI 279
            ||||||||||||||||||||||||||||||||||||||||||||||||||| |||||||||||||
Zfish   196 FGCMSVLANYFVFMTFFPACVSLVLELSRESREGRPIWQLSHFARVLEEEEDNKPNPVTQRVKMI 260

Human   280 MSLGLVLVHAHSRWIADPSPQNSTADTSKVSLGLDENVSKRIEPSVSLWQFYLSKMISMDIEQVI 344
            ||||||:|||||||||||:..:.|.|..:|.:.|:||:.|||||.:.||.||||:||||||||||
Zfish   261 MSLGLVMVHAHSRWIADPASSDGTLDLPEVGMSLNENLPKRIEPDMPLWHFYLSRMISMDIEQVI 325

Human   345 TLSLALLLAVKYIFFEQTETESTLSLKNPITSPVVTQKKVPDNCCRREPMLVRNNQKCDS----- 404
            ||.|||.||||||||||.|.|||||||.|..|.::|||..||.|||:|   :..:.|.|.
Zfish   326 TLGLALFLAVKYIFFEQVEMESTLSLKVPTPSSMLTQKWSPDQCCRKE---IPYSTKLDKPPTPP 387

Human   405 ---VEEETGIN---------RERKVE-----------VIKPLVAETDTPNRATFVVGNSSLLDTS 446
               .:||.||:         |.|.:.           ||:||.|..:...::|||:|.....:.:
Zfish   388 PIVTKEERGISFLRLNLIFLRFRSLTESNCKSSPLDLVIRPLPAPKEPEQKSTFVLGEDETQENT 452

Human   447 SVLVTQEPEIELPREPRPNEECLQILGNAEKGAKFLSDAEIIQLVNAKHIPAYKLETLMETHERG 511
            .|   .||.:.||.||||.|:||.||.|.:.||::|||.|:|.|||:|||||||||.:|||.|||
Zfish   453 HV---SEPVMSLPAEPRPVEDCLSILKNPDMGARYLSDEEVIVLVNSKHIPAYKLEAMMETPERG 514

Human   512 VSIRRQLLSKKLSEPSSLQYLPYRDYNYSLVMGACCENVIGYMPIPVGVAGPLCLDEKEFQVPMA 576
            |.|||::||.|..|||:|..|||:||:||.|||.||||||||||:||||||||.||.|:||||||
Zfish   515 VMIRRKMLSPKFPEPSTLSCLPYKDYDYSKVMGTCCENVIGYMPVPVGVAGPLLLDGKQFQVPMA 579

Human   577 TTEGCLVASTNRGCRAIGLGGGASSRVLADGMTRGPVVRLPRACDSAEVKAWLETSEGFAVIKEA 641
            |||||||||||||||||.|.|||||||||||||||||||.|.||.:||||||||:.|||..||||
Zfish   580 TTEGCLVASTNRGCRAIALAGGASSRVLADGMTRGPVVRFPSACQAAEVKAWLESPEGFKTIKEA 644

Human   642 FDSTSRFARLQKLHTSIAGRNLYIRFQSRSGDAMGMNMISKGTEKALSKLHEYFPEMQILAVSGN 706
            ||.|||||||:||...:|.||||||||||:||||||||||||||:||::|.|.|||:|:||||||
Zfish   645 FDQTSRFARLEKLLIGLASRNLYIRFQSRTGDAMGMNMISKGTEQALARLKEEFPELQVLAVSGN 709

Human   707 YCTDKKPAAINWIEGRGKSVVCEAVIPAKVVREVLKTTTEAMIEVNINKNLVGSAMAGSIGGYNA 771
            |||||||||||||||||||||||..||||||:|:|||:|||:::|||:|||||||||||||||||
Zfish   710 YCTDKKPAAINWIEGRGKSVVCETTIPAKVVKEILKTSTEALVDVNISKNLVGSAMAGSIGGYNA 774

Human   772 HAANIVTAIYIACGQDAAQNVGSSNCITLMEASGPTNEDLYISCTMPSIEIGTVGGGTNLLPQQA 836
            ||||||.|||||||||.||.||||||||||||||.|.|||||||||||||:|||||||||.||||
Zfish   775 HAANIVAAIYIACGQDPAQTVGSSNCITLMEASGATGEDLYISCTMPSIELGTVGGGTNLPPQQA 839

Human   837 CLQMLGVQGACKDNPGENARQLARIVCGTVMAGELSLMAALAAGHLVKSHMIHNRSKINLQDLQG 901
            ||:||||.||.::.|||||||||::||.||:|||||||:||||||||||||.|||||:|||:..|
Zfish   840 CLKMLGVLGASQECPGENARQLAKVVCATVLAGELSLMSALAAGHLVKSHMTHNRSKVNLQEAPG 904

Human   902 ACTKKTA 908
            .|||:.:
Zfish   905 TCTKQAS 911

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HMGCR	XP_011541659.1	2A060605	21..908	CDD:273339	697/915 (76%)
hmgcra	XP_073806595.1	None