Protein Alignment HMGCR and Hmgcr

DIOPT Version :10

• Sequence 1: XP_011541659.1
• Gene: HMGCR / 3156
• HGNCID: 5006
• Length: 908
• Species: Homo sapiens
• Sequence 2: NP_732900.1
• Gene: Hmgcr / 42803
• FlyBaseID: FBgn0263782
• Length: 920
• Species: Drosophila melanogaster
• Alignment Length: 946
• Identity: 435/946 - (45%)
• Similarity: 586/946 - (61%)
• Gaps: 118/946 - (12%)

Human    21 MLSRLFRMHGLFVASHPWEVIVGTVTLTICMMSMNMFTGNNKI---------------------- 63
            |:.||||.||.|.|||||||||..:|:|.||::::.   ||.:
  Fly     1 MIGRLFRAHGEFCASHPWEVIVALLTITACMLTVDK---NNTLDASSGLGTATASAAAAGGSGSG 62

Human    64 -------------------------C-GWNYECPKFEEDVLSSDIIILTITRCIAILYIYFQFQN 102
                                     | ||:..|...|.:..::|:|::||.||.|:||.|:||.:
  Fly    63 AGSGASGTIPPSSMGGSATSSRHRPCHGWSQSCDGLEAEYNAADVILMTIVRCTAVLYCYYQFCS 127

Human   103 LRQLGSKYILGIAGLFTIFSSFVFSTVVIHFLDKELTGLNEALPFFLLLIDLSRASTLAKFALSS 167
            |.:|||||:||||||||:||||:|:|.:|.||..:::.|.:||.|.||:||||.:..||:.|||.
  Fly   128 LHRLGSKYVLGIAGLFTVFSSFIFTTAIIKFLGSDISELKDALFFLLLVIDLSNSGRLAQLALSG 192

Human   168 NSQDEVRENIARGMAILGPTFTLDALVECLVIGVGTMSGVRQLEIMCCFGCMSVLANYFVFMTFF 232
            ::|.||.:|||||:.:|||..:||.:||.|::||||:|||::||::|.|..:|||.||.|||||:
  Fly   193 SNQAEVTQNIARGLELLGPAISLDTIVEVLLVGVGTLSGVQRLEVLCMFAVLSVLVNYVVFMTFY 257

Human   233 PACVSLVLELS---------RESREGRPIWQLSHFARVLEEEENKPNPVTQRVKMIMSLGLVLVH 288
            |||:||:.:||         ||..:|      |...:.|.|||.|.|||.||||:||:.||:.||
  Fly   258 PACLSLIFDLSRSGVDMSVVREKAKG------SLLLKSLTEEEQKANPVLQRVKLIMTTGLMAVH 316

Human   289 AHSRWIADPSPQNSTADTSKVSLGLDENVSKRIEPSVSLWQFYLSKMISMDIEQVITLSLALLLA 353
            .:||.....|..::...|...:|.|  |||.....|..:....: |.::|..:.::...:.:.|.
  Fly   317 IYSRVAFSGSDYDAVDKTLTPTLSL--NVSNNRTESGEIADIII-KWLTMSADHIVISIVLIALV 378

Human   354 VKYIFFEQTETESTLSLKNPITSPVVTQKKVPDNCCRREPMLVRNNQKCDSVEEETGINRERKVE 418
            ||:|.|:.         ::|:          ||...:..|:.:     .....:.|.|:.|. ||
  Fly   379 VKFICFDN---------RDPL----------PDQLRQSGPVAI-----AAKASQTTPIDEEH-VE 418

Human   419 VIKPLVAETDTPNRATFVVGNSSLLDTSSVLVTQEPEIELP---------REPRPNEECLQILGN 474
                  .|.||.|.|.......::.|.||...:.:.:: ||         :.|||.:|||.||.:
  Fly   419 ------QEKDTENSAAVRTLLFTIEDQSSANASTQTDL-LPLRHRLVGPIKPPRPVQECLDILNS 476

Human   475 AEKGA--KFLSDAEIIQLVNA--KHIPAYKLETLMETHERGVSIRRQLLSKKLSEP-SSLQYLPY 534
            .|:|:  ..|||.||:.:|:|  .|.|.:|:|::::..||||.||||::..:...| ..|..|||
  Fly   477 TEEGSGPAALSDEEIVSIVHAGGTHCPLHKIESVLDDPERGVRIRRQIIGSRAKMPVGRLDVLPY 541

Human   535 RDYNYSLVMGACCENVIGYMPIPVGVAGPLCLDEKEFQVPMATTEGCLVASTNRGCRAIGLGGGA 599
            ..::|..|:.||||||:||:|||||.||||.||.:.:.||||||||.|||||||||:|:.:.|..
  Fly   542 EHFDYRKVLNACCENVLGYVPIPVGYAGPLLLDGETYYVPMATTEGALVASTNRGCKALSVRGVR 606

Human   600 SSRVLAD-GMTRGPVVRLPRACDSAEVKAWLETSEGFAVIKEAFDSTSRFARLQKLHTSIAGRNL 663
            |  |:.| ||||.|.||.|....:||.|:|:|..|.:.|:|..|||||||.||:..|.::.|..|
  Fly   607 S--VVEDVGMTRAPCVRFPSVARAAEAKSWIENDENYRVVKTEFDSTSRFGRLKDCHIAMDGPQL 669

Human   664 YIRFQSRSGDAMGMNMISKGTEKALSKLHEYFPEMQILAVSGNYCTDKKPAAINWIEGRGKSVVC 728
            ||||.:.:||||||||:|||.|.||.::...||:|||:::|||:|.||||||||||:||||.||.
  Fly   670 YIRFVAITGDAMGMNMVSKGAEMALRRIQLQFPDMQIISLSGNFCCDKKPAAINWIKGRGKRVVT 734

Human   729 EAVIPAKVVREVLKTTTEAMIEVNINKNLVGSAMAGSIGGYNAHAANIVTAIYIACGQDAAQNVG 793
            |..|.|..:|.||||..:.::|.|..||:.||||||||||.||||||:|||:::|.|||.||||.
  Fly   735 ECTISAATLRSVLKTDAKTLVECNKLKNMGGSAMAGSIGGNNAHAANMVTAVFLATGQDPAQNVT 799

Human   794 SSNCITLMEASGPTNEDLYISCTMPSIEIGTVGGGTNLLPQQACLQMLGVQGACKDNPGENARQL 858
            ||||.|.||.....:||||::|||||:|:|||||||.|..|.|||:||||:||....||:||::|
  Fly   800 SSNCSTAMECWAENSEDLYMTCTMPSLEVGTVGGGTGLPGQSACLEMLGVRGAHATRPGDNAKKL 864

Human   859 ARIVCGTVMAGELSLMAALAAGHLVKSHMIHNRSKI 894
            |:|||.|||||||||||||....||||||.||||.|
  Fly   865 AQIVCATVMAGELSLMAALVNSDLVKSHMRHNRSSI 900

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HMGCR	XP_011541659.1	2A060605	21..908	CDD:273339	435/946 (46%)
Hmgcr	NP_732900.1	2A060605	1..920	CDD:273339	435/946 (46%)