Protein Alignment HMGCR and hmgr-1

DIOPT Version :10

• Sequence 1: XP_011541659.1
• Gene: HMGCR / 3156
• HGNCID: 5006
• Length: 908
• Species: Homo sapiens
• Sequence 2: NP_498626.2
• Gene: hmgr-1 / 176047
• WormBaseID: WBGene00017268
• Length: 550
• Species: Caenorhabditis elegans
• Alignment Length: 528
• Identity: 238/528 - (45%)
• Similarity: 306/528 - (57%)
• Gaps: 49/528 - (9%)

Human   400 QKCDSVEEETGINRERKVEVI-------------KPL--VAETD------TPNRATFVVGNSSLL 443
            |.||..:|.:     ||:|..             |||  |.|.|      :|.:.|...|.....
 Worm    13 QSCDISDEAS-----RKIENFICENYDQKEKPKRKPLFSVGEDDDSEEYVSPIKETCETGTQCKR 72

Human   444 DTSSVLVTQEPEIELPREPRPNEECLQILGNAEKGAKFLSDAEIIQLVNAKHIPAYKLETLMETH 508
            |      .:.||||      .....|..:....|..|.::..|.::|:......:.:||:....
 Worm    73 D------VEYPEIE------SGNRSLDEISREWKECKDVTPGEAVRLLRRGQAKSRELESRFPA- 124

Human   509 ERGVSIRRQLLSKKLSEPSSLQYLPYRDYNYSLVMGACCENVIGYMPIPVGVAGPLCLD-EKEFQ 572
            |:.:.|||..::||      .:.|||..|:|:|....||||||||.|:||||||||.|: ..|..
 Worm   125 EQAIPIRRTFINKK------FENLPYLGYDYTLATECCCENVIGYTPVPVGVAGPLTLNGTSEIY 183

Human   573 VPMATTEGCLVASTNRGCRAIGLGGGASSRVLADGMTRGPVVRLPRACDSAEVKAWLETSEGFAV 637
            ||||||||.|:||||||...|...||..:.:...||||.|||:.|.|.|:..:|.|||..|....
 Worm   184 VPMATTEGALIASTNRGMNVIRAAGGVETSIFNSGMTRAPVVKFPTARDAVSMKRWLEHPENQDR 248

Human   638 IKEAFDSTSRFARLQKLHTSIAGRNLYIRFQSRSGDAMGMNMISKGTEKALSKLHEYFPEMQILA 702
            .::.|.|.||||:|:.:..:|.|...|:||.:.:|||||||||||..:..:..|.|.||||.:||
 Worm   249 ARQEFQSCSRFAKLKSIDITIDGNLAYLRFDAHTGDAMGMNMISKSCDSTMRFLMENFPEMTVLA 313

Human   703 VSGNYCTDKKPAAINWIEGRGKSVVCEAVIPAKVVREVLKTTTEAMIEVNINKNLVGSAMAGSIG 767
            :|||.|.|||.||.||.||||:|||.|.:||.:||.:.|:||.|.:..:...|..:||:.||::|
 Worm   314 LSGNLCVDKKAAAKNWTEGRGRSVVAECLIPREVVTKTLRTTPEQLAYLTTTKLHIGSSRAGAVG 378

Human   768 GYNAHAANIVTAIYIACGQDAAQNVGSSNCITLMEASGPTNEDLYISCTMPSIEIGTVGGGTNLL 832
            |.||||||||.||:||.||||||.|.||.|.|.||.:...|  ||:|||:|.:|:|||||||.|.
 Worm   379 GSNAHAANIVAAIFIATGQDAAQVVSSSMCSTRMEVTADKN--LYVSCTLPCVEVGTVGGGTILA 441

Human   833 PQQACLQMLGVQGACKDNPGENARQLARIVCGTVMAGELSLMAALAAGHLVKSHMIHNRSKINL- 896
            ||:|||:.||..|..|:.||:||.:||.::..||:||||||||||....||.|||..||||..|
 Worm   442 PQRACLESLGCAGPNKEQPGQNAERLAEVIAATVLAGELSLMAALTTNELVSSHMKLNRSKQQLY 506

Human   897 QDLQGACT 904
            .|..|..|
 Worm   507 ADDSGKAT 514

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HMGCR	XP_011541659.1	2A060605	21..908	CDD:273339	238/528 (45%)
hmgr-1	NP_498626.2	HMG-CoA_reductase_classI	102..500	CDD:153081	206/406 (51%)