DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spx and Rbm7

DIOPT Version :9

Sequence 1:	NP_511058.1	Gene:	Spx / 31558	FlyBaseID:	FBgn0015818	Length:	347	Species:	Drosophila melanogaster
Sequence 2:	NP_659197.2	Gene:	Rbm7 / 67010	MGIID:	1914260	Length:	265	Species:	Mus musculus

Alignment Length:	228	Identity:	60/228 - (26%)
Similarity:	101/228 - (44%)	Gaps:	52/228 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 AERNQDATIYAGGLDDKVSETLLWELFVQAGPVVNVHMPKDRVTQMHQGYGFVEFLSEEDADYGI 71
            |....|.|::.|.|:.||:|.||:|||.|||||:.|.:|||:..::.| :.||.|..|....|.:
Mouse     4 AAAEADRTLFVGNLETKVTEELLFELFHQAGPVIKVKIPKDKDGKLKQ-FAFVNFKHEVSVPYAM 67

  Fly    72 KIMNMIKLYGKPIRV--NKASAHQKNLDVGANI---FIGNLDVEVDEKLLYDTFSAFGVILQTPK 131
            .::|.|||:|:||::  ...|:|... |...:.   .:|||.........|:  ...|.:..|.:
Mouse    68 NLLNGIKLFGRPIKIQFRSGSSHASQ-DASVSYPQHHVGNLSPTSTSPNSYE--RTVGNVSPTAQ 129

  Fly   132 IMR----DPETGKSKS-----FAFINFA----------------------SFEASDAA---MDAM 162
            :::    .||..:.::     |..:::|                      :|..|.::   .||:
Mouse   130 MVQRSFSSPEDYQRQAVMNSVFRQMSYAGKFGSPHADQLGFSPSAQPHGHTFNQSSSSQWRQDAL 194

  Fly   163 NGQ--------YLCNRPISVSYAFKKDHKGERH 187
            :.|        ||.:|..|....: .||..:.|
Mouse   195 SSQRKRQNSHPYLADRHYSREQRY-SDHGSDYH 226

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spx	NP_511058.1	RRM1_SF3B4	15..88	CDD:240780	32/74 (43%)
Spx	NP_511058.1	RRM2_SF3B4	99..181	CDD:240781	19/126 (15%)
Rbm7	NP_659197.2	RRM	<9..>101	CDD:223796	37/93 (40%)
		RRM_RBM7	9..83	CDD:241036	34/74 (46%)
		ZCCHC8 binding. /evidence=ECO:0000250\|UniProtKB:Q9Y580	25..35		7/9 (78%)
		ZCCHC8 binding. /evidence=ECO:0000250\|UniProtKB:Q9Y580	59..76		5/16 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	91..125		6/36 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	166..224		11/58 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	237..265
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D491103at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920