Protein Alignment Spx and PABPC3

DIOPT Version :10

• Sequence 1: NP_511058.1
• Gene: Spx / 31558
• FlyBaseID: FBgn0015818
• Length: 347
• Species: Drosophila melanogaster
• Sequence 2: NP_112241.2
• Gene: PABPC3 / 5042
• HGNCID: 8556
• Length: 631
• Species: Homo sapiens
• Alignment Length: 481
• Identity: 109/481 - (22%)
• Similarity: 161/481 - (33%)
• Gaps: 184/481 - (38%)

  Fly    13 ATIYAGGLDDKVSETLLWELFVQAGPVVNVHMPKDRVTQMHQGYGFVEFLSEEDADYGIKIMNMI 77
            |::|.|.|...|:|.:|:|.|..|||::::.:.:|.:|.....|.:|.|...:||::.:..||..
Human    11 ASLYVGDLHPDVTEAMLYEKFSPAGPILSIRICRDLITSGSSNYAYVNFQHTKDAEHALDTMNFD 75

  Fly    78 KLYGKPIRV--NKASAHQKNLDVGANIFIGNLDVEVDEKLLYDTFSAFGVILQ------------ 128
            .:.|||:|:  ::.....:...|| |||:.|||..::.|.||||.||||.||.
Human    76 VIKGKPVRIMWSQRDPSLRKSGVG-NIFVKNLDKSINNKALYDTVSAFGNILSCNVVCDENGSKG 139

  Fly   129 ----------------------------------------------------------------- 128
                                                                             
Human   140 YGFVHFETHEAAERAIKKMNGMLLNGRKVFVGQFKSRKEREAELGARAKEFPNVYIKNFGEDMDD 204

  Fly   129 --------------TPKIMRDPETGKSKSFAFINFASFEASDAAMDAMNGQYLCNRPISVSYAFK 179
                          :.|:|.| |:||||.|.|::|...|.:..|:|.|||:.|..:.|.|..|.|
Human   205 ERLKDLFGKFGPALSVKVMTD-ESGKSKGFGFVSFERHEDAQKAVDEMNGKELNGKQIYVGRAQK 268

  Fly   180 K------------DHKGER---------------HGSAAERLLAAQNP----------------- 200
            |            ..|.:|               .|...|||..|.:|
Human   269 KVERQTELKRTFEQMKQDRITRYQVVNLYVKNLDDGIDDERLRKAFSPFGTITSAKVMMEGGRSK 333

  Fly   201 ------------STHA--DRPHQLFADAPVQTMMPQMPGQIPAQMPGQMMP--------PPMMAP 243
                        :|.|  :...::.|..|:...:.|...:..|.:..:.|.        |...||
Human   334 GFGFVCFSSPEEATKAVTEMNGRIVATKPLYVALAQRKEERQAYLTNEYMQRMASVRAVPNQRAP 398

  Fly   244 PPPVVPVSNNNMGMLAPPPPVPQPAPFPATIPPPPLPPMTGGQPPLP--PAMGIPPPPRMMQPNA 306
            |        :...|.|    |||.....|..||..:..:.    |.|  .|.|..|.|...:|:|
Human   399 P--------SGYFMTA----VPQTQNHAAYYPPSQIARLR----PSPRWTAQGARPHPFQNKPSA 447

  Fly   307 WAPPGMPAPPPRPPPTNWRPPPVPFP 332
            ..|..     ||.|.:..||.....|
Human   448 IRPGA-----PRVPFSTMRPASSQVP 468

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Spx	NP_511058.1	RRM1_SF3B4	15..88	CDD:409771	24/74 (32%)
		RRM2_SF3B4	99..181	CDD:409772	41/184 (22%)
PABPC3	NP_112241.2	PABP-1234	11..610	CDD:130689	109/481 (23%)