DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spx and sf3b4

DIOPT Version :9

Sequence 1:	NP_511058.1	Gene:	Spx / 31558	FlyBaseID:	FBgn0015818	Length:	347	Species:	Drosophila melanogaster
Sequence 2:	NP_989116.1	Gene:	sf3b4 / 394721	XenbaseID:	XB-GENE-492933	Length:	388	Species:	Xenopus tropicalis

Alignment Length:	387	Identity:	250/387 - (64%)
Similarity:	271/387 - (70%)	Gaps:	51/387 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAAGPIAERNQDATIYAGGLDDKVSETLLWELFVQAGPVVNVHMPKDRVTQMHQGYGFVEFLSEE 65
            ||||||:|||||||:|.||||:||||.||||||:|||||||.||||||||..|||||||||||||
Frog     1 MAAGPISERNQDATVYVGGLDEKVSEPLLWELFLQAGPVVNTHMPKDRVTGQHQGYGFVEFLSEE 65

  Fly    66 DADYGIKIMNMIKLYGKPIRVNKASAHQKNLDVGANIFIGNLDVEVDEKLLYDTFSAFGVILQTP 130
            ||||.||||||||||||||||||||||.|||||||||||||||.|:|||||||||||||||||||
Frog    66 DADYAIKIMNMIKLYGKPIRVNKASAHNKNLDVGANIFIGNLDPEIDEKLLYDTFSAFGVILQTP 130

  Fly   131 KIMRDPETGKSKSFAFINFASFEASDAAMDAMNGQYLCNRPISVSYAFKKDHKGERHGSAAERLL 195
            ||||||:||.||.:||||||||:|||||::||||||||||||:||||||||.|||||||||||||
Frog   131 KIMRDPDTGNSKGYAFINFASFDASDAAIEAMNGQYLCNRPITVSYAFKKDSKGERHGSAAERLL 195

  Fly   196 AAQNPSTHADRPHQLFADAPVQTMMPQ------------MPGQIPAQMPGQMMP--PPMMAPPPP 246
            |||||.:.||||||||||||....:|.            ||...|...||.|.|  ||.| ||||
Frog   196 AAQNPLSQADRPHQLFADAPPPPSVPAVITSLTSAVAAGMPTFPPVPPPGAMPPGIPPSM-PPPP 259

  Fly   247 VVPVS---------------------NNNMGMLAPPPPVPQPAPFPATIPP---PPLPPMTGGQP 287
            :.||:                     :..|.|..|.|.:|..:|. .|.||   ||.||..|..|
Frog   260 MSPVTGAGQAAAAAPQVPLPFQSAAMHPGMQMQMPHPSIPGASPL-GTRPPGMGPPGPPPMGMPP 323

  Fly   288 PLPP--AMGIPPPPRMMQPNAWAPPGMPA--PPPRPPPTNWRPPPVPFP---PTPYARPYQP 342
            ..||  |||.|..|..|:|    ||.||.  .||||||..::..|||.|   |.|.|.|..|
Frog   324 RAPPFGAMGHPGMPPGMRP----PPLMPPYNGPPRPPPYGYQRAPVPLPRPAPRPPAPPRPP 381

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spx	NP_511058.1	RRM1_SF3B4	15..88	CDD:240780	63/72 (88%)
Spx	NP_511058.1	RRM2_SF3B4	99..181	CDD:240781	71/81 (88%)
sf3b4	NP_989116.1	RRM1_SF3B4	15..88	CDD:240780	63/72 (88%)
sf3b4	NP_989116.1	RRM2_SF3B4	99..181	CDD:240781	71/81 (88%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	139	1.000	Domainoid score	I4771
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	433	1.000	Inparanoid score	I1672
OMA	1	1.010	-	-		QHG59594
OrthoDB	1	1.010	-	-		D1479417at2759
OrthoFinder	1	1.000	-	-		FOG0004820
OrthoInspector	1	1.000	-	-		oto103768
Panther	1	1.100	-	-	LDO	PTHR24012
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3402
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	10.080