DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spx and RBMY1D

DIOPT Version :9

Sequence 1:	NP_511058.1	Gene:	Spx / 31558	FlyBaseID:	FBgn0015818	Length:	347	Species:	Drosophila melanogaster
Sequence 2:	NP_001006120.2	Gene:	RBMY1D / 378949	HGNCID:	23915	Length:	496	Species:	Homo sapiens

Alignment Length:	277	Identity:	69/277 - (24%)
Similarity:	101/277 - (36%)	Gaps:	67/277 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    97 DVGANIFIGNLDVEVDEKLLYDTFSAFGVILQTPKIMRDPETGKSKSFAFINFAS-FEASDAAMD 160
            |....:|||.|:.|.:||:|...|...|.|.:. .:::| .|.||:.||||.|.: .:|.:||.|
Human     5 DHPGKLFIGGLNRETNEKMLKAVFGKHGPISEV-LLIKD-RTSKSRGFAFITFENPADAKNAAKD 67

  Fly   161 AMNGQYLCNRPISVSYAFKKDHK--GERHGSAAERLLAAQNPSTHADRPHQLFADAPVQTMMPQM 223
             |||:.|..:.|.|..|.|...:  |.|...|:.|     |.|..........:....:..:|..
Human    68 -MNGKSLHGKAIKVEQAKKPSFQSGGRRRPPASSR-----NRSPSGSLRSARGSRGGTRGWLPSQ 126

  Fly   224 PGQIPAQMPGQMMPPPMMAPPPPVVPVSNNNMGMLAPPPPVPQPAPFPATIPPPPLPPMTGGQPP 288
            .|.:.   .|...|...|:....::||...                 |::        .:||.||
Human   127 EGHLD---DGGYTPDLKMSYSRGLIPVKRG-----------------PSS--------RSGGPPP 163

  Fly   289 LPPAMGIPPPPRMMQPNAWAPPGMP---------APPPRPPPTNWRPPPVPFPPTPYA------- 337
            ...|     |..:.:.|:|.....|         .||.|...::||...:......||
Human   164 KKSA-----PSAVARSNSWMGSQGPMSQRRENYGVPPRRATISSWRNDRMSTRHDGYATNDGNHP 223

  Fly   338 -----RPYQPD--GYQY 347
                 |.|.|.  ||.|
Human   224 SCQETRDYAPPSRGYAY 240

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spx	NP_511058.1	RRM1_SF3B4	15..88	CDD:240780
Spx	NP_511058.1	RRM2_SF3B4	99..181	CDD:240781	32/82 (39%)
RBMY1D	NP_001006120.2	RRM	<1..189	CDD:223796	56/224 (25%)
		RRM_RBMX_like	7..85	CDD:240828	31/80 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	67..349		45/213 (21%)
		RBM1CTR	174..218	CDD:285341	10/43 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	452..496
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910