DRSC/TRiP Functional Genomics Resources

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Protein Alignment Spx and PABPC1

DIOPT Version :10

Sequence 1:NP_511058.1 Gene:Spx / 31558 FlyBaseID:FBgn0015818 Length:347 Species:Drosophila melanogaster
Sequence 2:NP_002559.2 Gene:PABPC1 / 26986 HGNCID:8554 Length:636 Species:Homo sapiens


Alignment Length:497 Identity:118/497 - (23%)
Similarity:163/497 - (32%) Gaps:194/497 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 PIAERNQDATIYAGGLDDKVSETLLWELFVQAGPVVNVHMPKDRVTQMHQGYGFVEFLSEEDADY 69
            |.|.....|::|.|.|...|:|.:|:|.|..|||::::.:.:|.:|:...||.:|.|....||:.
Human     3 PSAPSYPMASLYVGDLHPDVTEAMLYEKFSPAGPILSIRVCRDMITRRSLGYAYVNFQQPADAER 67

  Fly    70 GIKIMNMIKLYGKPIRV--NKASAHQKNLDVGANIFIGNLDVEVDEKLLYDTFSAFGVILQ---- 128
            .:..||...:.|||:|:  ::.....:...|| ||||.|||..:|.|.|||||||||.||.    
Human    68 ALDTMNFDVIKGKPVRIMWSQRDPSLRKSGVG-NIFIKNLDKSIDNKALYDTFSAFGNILSCKVV 131

  Fly   129 ----------------------------------------------------------------- 128
                                                                             
Human   132 CDENGSKGYGFVHFETQEAAERAIEKMNGMLLNDRKVFVGRFKSRKEREAELGARAKEFTNVYIK 196

  Fly   129 ----------------------TPKIMRDPETGKSKSFAFINFASFEASDAAMDAMNGQYLCNRP 171
                                  :.|:|.| |:||||.|.|::|...|.:..|:|.|||:.|..:.
Human   197 NFGEDMDDERLKDLFGKFGPALSVKVMTD-ESGKSKGFGFVSFERHEDAQKAVDEMNGKELNGKQ 260

  Fly   172 ISVSYAFKK------------DHKGER---------------HGSAAERLLAAQNP--------- 200
            |.|..|.||            ..|.:|               .|...|||....:|         
Human   261 IYVGRAQKKVERQTELKRKFEQMKQDRITRYQGVNLYVKNLDDGIDDERLRKEFSPFGTITSAKV 325

  Fly   201 --------------------STHA--DRPHQLFADAPVQTMMPQMPGQIPAQMPGQMMP--PPMM 241
                                :|.|  :...::.|..|:...:.|...:..|.:..|.|.  ..:.
Human   326 MMEGGRSKGFGFVCFSSPEEATKAVTEMNGRIVATKPLYVALAQRKEERQAHLTNQYMQRMASVR 390

  Fly   242 APPPPVVPVSNNNMGMLAPPPPVPQPAPFPATIP---------PP-------PLPPMTGGQPPLP 290
            |.|.||:          .|..|.|....|.|.||         ||       |.|..|       
Human   391 AVPNPVI----------NPYQPAPPSGYFMAAIPQTQNRAAYYPPSQIAQLRPSPRWT------- 438

  Fly   291 PAMGIPPPPRMMQPNAWAPPGMPAPPPRPPPTNWRPPPVPFP 332
             |.|..|.|....|.|..|..     ||||.:..||.....|
Human   439 -AQGARPHPFQNMPGAIRPAA-----PRPPFSTMRPASSQVP 474

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SpxNP_511058.1 RRM1_SF3B4 15..88 CDD:409771 25/74 (34%)
RRM2_SF3B4 99..181 CDD:409772 44/184 (24%)
PABPC1NP_002559.2 PABP-1234 11..615 CDD:130689 116/489 (24%)
CSDE1-binding 166..289 25/123 (20%)
(Microbial infection) Binding to HRSV M2-1 protein. /evidence=ECO:0000269|PubMed:31649314 541..636
Blue background indicates that the domain is not in the aligned region.

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