DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spx and sap49

DIOPT Version :9

Sequence 1:	NP_511058.1	Gene:	Spx / 31558	FlyBaseID:	FBgn0015818	Length:	347	Species:	Drosophila melanogaster
Sequence 2:	NP_594001.2	Gene:	sap49 / 2542426	PomBaseID:	SPAC31G5.01	Length:	335	Species:	Schizosaccharomyces pombe

Alignment Length:	353	Identity:	156/353 - (44%)
Similarity:	213/353 - (60%)	Gaps:	44/353 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 ERNQDATIYAGGLDDKVSETLLWELFVQAGPVVNVHMPKDRVTQMHQGYGFVEFLSEEDADYGIK 72
            :||||||||.|.||:||::::|:||.:|||||||:|:|:|||...|.|:||.|||.|:|.:|..:
pombe     6 DRNQDATIYLGNLDEKVTDSILFELCLQAGPVVNIHIPRDRVRNSHNGFGFCEFLHEQDVEYACQ 70

  Fly    73 IMNMIKLYGKPIRVNKASAHQ-KNLDVGANIFIGNLDVEVDEKLLYDTFSAFGVILQTPKIMRDP 136
            |:|.:||:|||||||:||..: .|..:|||:|:||||..|||::|||||||.|.:::.|::.||
pombe    71 ILNQVKLFGKPIRVNRASQDRGVNTLIGANLFVGNLDPLVDERVLYDTFSALGQLVKAPQVARD- 134

  Fly   137 ETGKSKSFAFINFASFEASDAAMDAMNGQYLCNRPISVSYAFKKDHKGERHGSAAERLLAAQNPS 201
            |.|:||.:.|:::.|||.:|||::|||.|:|.|:||:||||||::.||||||..|||.|||
pombe   135 ENGRSKGYGFVSYDSFETADAAIEAMNNQFLMNKPITVSYAFKREGKGERHGDIAERKLAA---- 195

  Fly   202 THADRPHQLFADAPVQTMMPQMPGQIPAQMPGQMMPPPMMA---PPPPVVPVSNNNMGMLAPPPP 263
              |.:.::: |..|..|:.|......||.......|..:.|   ||.|.||:......:  ||..
pombe   196 --AAKKNKV-AVTPQSTLPPGFSPATPAPTSAANTPATIAATSIPPVPNVPLVGATTAV--PPLS 255

  Fly   264 VPQPAPFPATIPPPPLP-------PMTGGQPPLPPAMGIPPPPRMM----QPNAWAPPGMPAPPP 317
            :|...||.|....|.:|       ||..|..||.|    ||||.|:    .|.|...||.|.
pombe   256 IPNVLPFTAAQHFPGMPAMPMMNVPMGPGGAPLVP----PPPPGMVMASPSPAAATIPGAPV--- 313

  Fly   318 RPPPTNWRPPPVPFPPTPYARPYQPDGY 345
                    .|.:||..|..|:    :||
pombe   314 --------MPNIPFYQTINAQ----NGY 329

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spx	NP_511058.1	RRM1_SF3B4	15..88	CDD:240780	42/72 (58%)
Spx	NP_511058.1	RRM2_SF3B4	99..181	CDD:240781	47/81 (58%)
sap49	NP_594001.2	RRM1_SF3B4	13..86	CDD:240780	42/72 (58%)
sap49	NP_594001.2	RRM2_SF3B4	98..179	CDD:240781	47/81 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	99	1.000	Domainoid score	I1861
eggNOG	1	0.900	-	-		E1_KOG0131
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	267	1.000	Inparanoid score	I725
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004820
OrthoInspector	1	1.000	-	-		oto101242
orthoMCL	1	0.900	-	-		OOG6_102421
Panther	1	1.100	-	-	LDO	PTHR24012
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1284
SonicParanoid	1	1.000	-	-		X3402
TreeFam	1	0.960	-	-
	12	11.850