Protein Alignment Spx and SF3B4

DIOPT Version :9

• Sequence 1: NP_511058.1
• Gene: Spx / 31558
• FlyBaseID: FBgn0015818
• Length: 347
• Species: Drosophila melanogaster
• Sequence 2: NP_005841.1
• Gene: SF3B4 / 10262
• HGNCID: 10771
• Length: 424
• Species: Homo sapiens
• Alignment Length: 418
• Identity: 250/418 - (59%)
• Similarity: 275/418 - (65%)
• Gaps: 81/418 - (19%)

  Fly     1 MAAGPIAERNQDATIYAGGLDDKVSETLLWELFVQAGPVVNVHMPKDRVTQMHQGYGFVEFLSEE 65
            ||||||:|||||||:|.||||:||||.||||||:|||||||.||||||||..|||||||||||||
Human     1 MAAGPISERNQDATVYVGGLDEKVSEPLLWELFLQAGPVVNTHMPKDRVTGQHQGYGFVEFLSEE 65

  Fly    66 DADYGIKIMNMIKLYGKPIRVNKASAHQKNLDVGANIFIGNLDVEVDEKLLYDTFSAFGVILQTP 130
            ||||.||||||||||||||||||||||.|||||||||||||||.|:|||||||||||||||||||
Human    66 DADYAIKIMNMIKLYGKPIRVNKASAHNKNLDVGANIFIGNLDPEIDEKLLYDTFSAFGVILQTP 130

  Fly   131 KIMRDPETGKSKSFAFINFASFEASDAAMDAMNGQYLCNRPISVSYAFKKDHKGERHGSAAERLL 195
            ||||||:||.||.:||||||||:|||||::||||||||||||:||||||||.|||||||||||||
Human   131 KIMRDPDTGNSKGYAFINFASFDASDAAIEAMNGQYLCNRPITVSYAFKKDSKGERHGSAAERLL 195

  Fly   196 AAQNPSTHADRPHQLFADAPVQTMMPQMPGQIPAQMPGQMMPPPMMAP----PPPVVPVSNNNMG 256
            |||||.:.||||||||||||..   |..|..:.:.: |..:|||.|.|    ||||.|......|
Human   196 AAQNPLSQADRPHQLFADAPPP---PSAPNPVVSSL-GSGLPPPGMPPPGSFPPPVPPPGALPPG 256

  Fly   257 M--LAPPPPVP------------------------QPAPF-PATIPPPPL--------------- 279
            :  ..||||:|                        .|.|| |..:|.|.:
Human   257 IPPAMPPPPMPPGAAGHGPPSAGTPGAGHPGHGHSHPHPFPPGGMPHPGMSQMQLAHHGPHGLGH 321

  Fly   280 ----PPMTGGQPPL----------PPAMGIPP--PP---RMMQPNAWAPPGMPAP---------- 315
                ||.:|||||.          ||.||:||  ||   .|..|....|.||..|
Human   322 PHAGPPGSGGQPPPRPPPGMPHPGPPPMGMPPRGPPFGSPMGHPGPMPPHGMRGPPPLMPPHGYT 386

  Fly   316 -PPRPPPTNWRPPPVPFPPTPYARPYQP 342
             ||||||..::..|:| ||.|..||..|
Human   387 GPPRPPPYGYQRGPLP-PPRPTPRPPVP 413

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Spx	NP_511058.1	RRM1_SF3B4	15..88	CDD:240780	63/72 (88%)
		RRM2_SF3B4	99..181	CDD:240781	71/81 (88%)
SF3B4	NP_005841.1	RRM1_SF3B4	15..88	CDD:409771	63/72 (88%)
		RRM2_SF3B4	99..181	CDD:409772	71/81 (88%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	207..424		69/212 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152620
Domainoid	1	1.000	134	1.000	Domainoid score	I5036
eggNOG	1	0.900	-	-		E1_KOG0131
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	442	1.000	Inparanoid score	I1663
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59594
OrthoDB	1	1.010	-	-		D1479417at2759
OrthoFinder	1	1.000	-	-		FOG0004820
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102421
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3402
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.670