Protein Alignment dtn and tmem132e

DIOPT Version :10

• Sequence 1: NP_001284933.1
• Gene: dtn / 31555
• FlyBaseID: FBgn0262730
• Length: 1407
• Species: Drosophila melanogaster
• Sequence 2: NP_001289163.1
• Gene: tmem132e / 564044
• ZFINID: ZDB-GENE-120926-3
• Length: 1073
• Species: Danio rerio
• Alignment Length: 1111
• Identity: 286/1111 - (25%)
• Similarity: 472/1111 - (42%)
• Gaps: 224/1111 - (20%)

  Fly    29 FFLKHARQPPVTPEIANVQTSSAVPPLRQRSSYDSVLSLDRFTVVETTQPVSIRASYGPFSTKQT 93
            |||:..|.|....:..:        || |||        :.|.|.:|.:..::..|.|||:..||
Zfish    66 FFLQENRAPSYGSQRGH--------PL-QRS--------ESFVVFQTKELPAVNISLGPFTQDQT 113

  Fly    94 VPARYIVPDTMDSQSGDYMNNATLLELQQPNMHLDI----------SAHLVRSSVSQDAPVLRVL 148
            :..                      :|.||:..|||          .|.:|:|.|....|:::||
Zfish   114 LSK----------------------DLLQPSSPLDIPGRLTVNWKVRAFIVQSRVYASNPLVQVL 156

  Fly   149 FH-AGAD-PGGHLQRQKVCVLLHVAMGSEQPLKGRCMPEGEDGVCVAEVVVPLGWWPQLPAP--T 209
            |: ||.| ....:|.:..||.|| |....:.:|..|..:|....|:|::.:|..|:....||  .
Zfish   157 FYIAGRDWDDFKIQDKLPCVRLH-AFRDVREIKTSCRLQGNLAQCLAQLDLPSTWFNVNVAPLGR 220

  Fly   210 QDGSGQAPPKVPQRYAQVS--YSVFEP----------PLR-NPEQCEPKVQIQPLTTFAQVPLLA 261
            :..||....::.....||.  |::.:|          |.| .|.:.|...| |||.....:.|.
Zfish   221 RKSSGTDGLELTGETLQVELYYTLHDPDSNDECGESYPRRGGPSRGESLSQ-QPLLRIGSISLY- 283

  Fly   262 ARTPYRMLRAD---DAVTFL-LPQHPLYPLSRLHVPVFLHQYPDQRVAAFTVRARVKAGLKILGA 322
             :.....|..|   |...|| ||:.||.|...|:  ::|...|:..|..||::.:.|.|:.:|..
Zfish   284 -QPSQEQLVVDKQLDKNLFLRLPERPLKPGETLN--IYLLLVPNSTVEQFTLKVKAKKGVNLLST 345

  Fly   323 TASTDQWSVSVEKEN-PKHTTARVTAFRKEAESSLESGGNLTSEVFEVFSWLLEVAEDTNDIVDG 386
            .:.::||.|..:.:: .||:.|.|.|.:.:..|     |::...: |:.....|:...|:..|.
Zfish   346 KSRSNQWRVEWDMQSGAKHSIATVEASKIKGVS-----GDMAGSI-EIMQLDFEMENFTSQSVT- 403

  Fly   387 GKIVWSVTHVYDTPKDKDSGELVIPDDNKKRLIAKLEINKDDIQAVLPMAKIWEVMNTAVLTGRQ 451
            .:|.|::.:         .|:  .|..:.::::.:|.:.:.||||::|::...|::||||||||.
Zfish   404 RRINWNIDY---------RGQ--NPTSDAEKVVTELTVVQKDIQAIIPLSMDTEIINTAVLTGRT 457

  Fly   452 VAQAMKVFIVSQAGKVADVTLQSSCHAEDESVIKVSSSCSSVYVDGSEQRGSSNASVIVKYGTYV 516
            ||..:||..:...|.|.||:....|.:.:|.::|||.:|..|:|:|.|.|||.||.||..|....
Zfish   458 VAIPVKVVSIELNGAVTDVSSSVQCKSFNEDIVKVSMNCDYVFVNGKETRGSMNARVIFSYEHLS 522

  Fly   517 GVAKFIVWMPEFPLEVYISDFRLSQIKGWKV-----------TDDNHYLHNKQSRRRKKRSYVWG 570
            ...:..||:|:.||:|.:||.|||.||||:|           :||:.....|.||.
Zfish   523 APLELTVWVPKLPLKVELSDNRLSFIKGWRVPILPDRRTARDSDDDDDDDRKVSRG--------- 578

  Fly   571 QHGTNYYNNLGADKTICRARYQQSPVEVYAKF-LAVDQNSGRTSYFISRRTGLRVTDLVQPLLRV 634
                            |..:||::.::|..:| ....:.:.:....:.....:.||:|||..|:|
Zfish   579 ----------------CTLQYQRAQIKVLTQFHTTSSEGTNQMITMLGPDWQVDVTELVQDSLKV 627

  Fly   635 ADPKIASLKGR-ILQGKSMGRTDVQVLSPI-TGRVIGTKEIRVGSDKVNLSKLIVRVISGLQLTI 697
            .|.::|.|..| :|....:|.:.::|.||: ...|:|..:..|..:||::.:|.|..||||.|.:
Zfish   628 VDGRVAELADRTVLVANELGSSTLKVESPLAVEAVLGETQFSVVDEKVSIVELRVHAISGLALNL 692

  Fly   698 SPDNTIENGYLAETSVTHKLTAQYQEGLLDIDLEFTDGSKTPLRDIAVEDYFLLVESLDTEVVAF 762
            .|.....:..:|:.:....|:...||....|.:.::|.:..||.....:||.|...|.|.:||..
Zfish   693 QPSPGNSHTMVAKATGLQTLSTLKQEASFSIWVYYSDNTAAPLSMYDPKDYNLNGTSADDKVVTV 757

  Fly   763 APMLASHHPRVIAVGEGNGNLLRVTLLLSEECRQ----------------RRGTLSSSKQNKSNA 811
            |.......|.:||.|||.|:::.|.:.:||.|::                |.||...|:::..
Zfish   758 AQQPQQRWPVIIAEGEGTGDIVHVEMTISETCQKTKRKSVIASSSVFVKVRFGTDEDSEEDME-- 820

  Fly   812 APLASALASIEVDFNNVDIVSKQEAI-QNDGTVGRERKNYRQTGDLADIIVGIPLRDSSQLYEPT 875
                   ...|:| ..:...:::.|| .|.|..|.|..|.:...      |.|...:...:..|.
Zfish   821 -------METEID-TRMPANTRRPAIDSNVGGAGYEPSNEQPAS------VPIDYTNFPTISNPE 871

  Fly   876 VQARQHRGSIQAVHKGHHGKGLAGTGTMTTMELGMYVLLTAFCFAIIVFVISCVVYASKFRPAMI 940
            ....:.....:.||...         :||.:|:|||.||..||.||:||:|:|:|:..|:|...|
Zfish   872 EPTEEDEEDDEFVHSPR---------SMTDLEIGMYALLGVFCLAILVFLINCIVFVLKYRHKRI 927

  Fly   941 ESGLDPLSAGKSNGSGGSGGFRDVRLKESTTNAHDWVWLG-------RSTIDRQSIVAETNTHLN 998
            .      ..|::|                ..::|.||:||       :|.:..|::.:.:|
Zfish   928 P------PEGQAN----------------MDHSHHWVFLGNGEPLRTQSDLSPQTVESPSN---- 966

  Fly   999 PRDSRMRITSNPIVNYDNGRRVSSFDQQPKLQTHIVPASNLNKQHADHYLANERKDNALDYKPPV 1063
                    |...:....:|...||...|..:|:.:       ....|.......||:..|...|.
Zfish   967 --------TLEGVQTCCHGDHHSSGSSQTSVQSQV-------HGRGDGSSGGSTKDHGEDASSPT 1016

  Fly  1064 PPHRNV 1069
            ...:.|
Zfish  1017 SKRKRV 1022

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dtn	NP_001284933.1	TMEM132D_N	18..170	CDD:464813	40/152 (26%)
		TMEM132	440..796	CDD:465003	117/369 (32%)
		TMEM132D_C	881..982	CDD:464814	29/107 (27%)
tmem132e	NP_001289163.1	TMEM132D_N	55..185	CDD:464813	42/158 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	246..270		5/23 (22%)
		TMEM132	446..791	CDD:465003	117/369 (32%)
		TMEM132D_C	<883..947	CDD:464814	29/94 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	952..1024		15/90 (17%)