DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dtn and tmem132e

DIOPT Version :9

Sequence 1:	NP_001284933.1	Gene:	dtn / 31555	FlyBaseID:	FBgn0262730	Length:	1407	Species:	Drosophila melanogaster
Sequence 2:	NP_001289163.1	Gene:	tmem132e / 564044	ZFINID:	ZDB-GENE-120926-3	Length:	1073	Species:	Danio rerio

Alignment Length:	1111	Identity:	286/1111 - (25%)
Similarity:	472/1111 - (42%)	Gaps:	224/1111 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 FFLKHARQPPVTPEIANVQTSSAVPPLRQRSSYDSVLSLDRFTVVETTQPVSIRASYGPFSTKQT 93
            |||:..|.|....:..:        || |||        :.|.|.:|.:..::..|.|||:..||
Zfish    66 FFLQENRAPSYGSQRGH--------PL-QRS--------ESFVVFQTKELPAVNISLGPFTQDQT 113

  Fly    94 VPARYIVPDTMDSQSGDYMNNATLLELQQPNMHLDI----------SAHLVRSSVSQDAPVLRVL 148
            :..                      :|.||:..|||          .|.:|:|.|....|:::||
Zfish   114 LSK----------------------DLLQPSSPLDIPGRLTVNWKVRAFIVQSRVYASNPLVQVL 156

  Fly   149 FH-AGAD-PGGHLQRQKVCVLLHVAMGSEQPLKGRCMPEGEDGVCVAEVVVPLGWWPQLPAP--T 209
            |: ||.| ....:|.:..||.|| |....:.:|..|..:|....|:|::.:|..|:....||  .
Zfish   157 FYIAGRDWDDFKIQDKLPCVRLH-AFRDVREIKTSCRLQGNLAQCLAQLDLPSTWFNVNVAPLGR 220

  Fly   210 QDGSGQAPPKVPQRYAQVS--YSVFEP----------PLR-NPEQCEPKVQIQPLTTFAQVPLLA 261
            :..||....::.....||.  |::.:|          |.| .|.:.|...| |||.....:.|.
Zfish   221 RKSSGTDGLELTGETLQVELYYTLHDPDSNDECGESYPRRGGPSRGESLSQ-QPLLRIGSISLY- 283

  Fly   262 ARTPYRMLRAD---DAVTFL-LPQHPLYPLSRLHVPVFLHQYPDQRVAAFTVRARVKAGLKILGA 322
             :.....|..|   |...|| ||:.||.|...|:  ::|...|:..|..||::.:.|.|:.:|..
Zfish   284 -QPSQEQLVVDKQLDKNLFLRLPERPLKPGETLN--IYLLLVPNSTVEQFTLKVKAKKGVNLLST 345

  Fly   323 TASTDQWSVSVEKEN-PKHTTARVTAFRKEAESSLESGGNLTSEVFEVFSWLLEVAEDTNDIVDG 386
            .:.::||.|..:.:: .||:.|.|.|.:.:..|     |::...: |:.....|:...|:..|.
Zfish   346 KSRSNQWRVEWDMQSGAKHSIATVEASKIKGVS-----GDMAGSI-EIMQLDFEMENFTSQSVT- 403

  Fly   387 GKIVWSVTHVYDTPKDKDSGELVIPDDNKKRLIAKLEINKDDIQAVLPMAKIWEVMNTAVLTGRQ 451
            .:|.|::.:         .|:  .|..:.::::.:|.:.:.||||::|::...|::||||||||.
Zfish   404 RRINWNIDY---------RGQ--NPTSDAEKVVTELTVVQKDIQAIIPLSMDTEIINTAVLTGRT 457

  Fly   452 VAQAMKVFIVSQAGKVADVTLQSSCHAEDESVIKVSSSCSSVYVDGSEQRGSSNASVIVKYGTYV 516
            ||..:||..:...|.|.||:....|.:.:|.::|||.:|..|:|:|.|.|||.||.||..|....
Zfish   458 VAIPVKVVSIELNGAVTDVSSSVQCKSFNEDIVKVSMNCDYVFVNGKETRGSMNARVIFSYEHLS 522

  Fly   517 GVAKFIVWMPEFPLEVYISDFRLSQIKGWKV-----------TDDNHYLHNKQSRRRKKRSYVWG 570
            ...:..||:|:.||:|.:||.|||.||||:|           :||:.....|.||.
Zfish   523 APLELTVWVPKLPLKVELSDNRLSFIKGWRVPILPDRRTARDSDDDDDDDRKVSRG--------- 578

  Fly   571 QHGTNYYNNLGADKTICRARYQQSPVEVYAKF-LAVDQNSGRTSYFISRRTGLRVTDLVQPLLRV 634
                            |..:||::.::|..:| ....:.:.:....:.....:.||:|||..|:|
Zfish   579 ----------------CTLQYQRAQIKVLTQFHTTSSEGTNQMITMLGPDWQVDVTELVQDSLKV 627

  Fly   635 ADPKIASLKGR-ILQGKSMGRTDVQVLSPI-TGRVIGTKEIRVGSDKVNLSKLIVRVISGLQLTI 697
            .|.::|.|..| :|....:|.:.::|.||: ...|:|..:..|..:||::.:|.|..||||.|.:
Zfish   628 VDGRVAELADRTVLVANELGSSTLKVESPLAVEAVLGETQFSVVDEKVSIVELRVHAISGLALNL 692

  Fly   698 SPDNTIENGYLAETSVTHKLTAQYQEGLLDIDLEFTDGSKTPLRDIAVEDYFLLVESLDTEVVAF 762
            .|.....:..:|:.:....|:...||....|.:.::|.:..||.....:||.|...|.|.:||..
Zfish   693 QPSPGNSHTMVAKATGLQTLSTLKQEASFSIWVYYSDNTAAPLSMYDPKDYNLNGTSADDKVVTV 757

  Fly   763 APMLASHHPRVIAVGEGNGNLLRVTLLLSEECRQ----------------RRGTLSSSKQNKSNA 811
            |.......|.:||.|||.|:::.|.:.:||.|::                |.||...|:::..
Zfish   758 AQQPQQRWPVIIAEGEGTGDIVHVEMTISETCQKTKRKSVIASSSVFVKVRFGTDEDSEEDME-- 820

  Fly   812 APLASALASIEVDFNNVDIVSKQEAI-QNDGTVGRERKNYRQTGDLADIIVGIPLRDSSQLYEPT 875
                   ...|:| ..:...:::.|| .|.|..|.|..|.:...      |.|...:...:..|.
Zfish   821 -------METEID-TRMPANTRRPAIDSNVGGAGYEPSNEQPAS------VPIDYTNFPTISNPE 871

  Fly   876 VQARQHRGSIQAVHKGHHGKGLAGTGTMTTMELGMYVLLTAFCFAIIVFVISCVVYASKFRPAMI 940
            ....:.....:.||...         :||.:|:|||.||..||.||:||:|:|:|:..|:|...|
Zfish   872 EPTEEDEEDDEFVHSPR---------SMTDLEIGMYALLGVFCLAILVFLINCIVFVLKYRHKRI 927

  Fly   941 ESGLDPLSAGKSNGSGGSGGFRDVRLKESTTNAHDWVWLG-------RSTIDRQSIVAETNTHLN 998
            .      ..|::|                ..::|.||:||       :|.:..|::.:.:|
Zfish   928 P------PEGQAN----------------MDHSHHWVFLGNGEPLRTQSDLSPQTVESPSN---- 966

  Fly   999 PRDSRMRITSNPIVNYDNGRRVSSFDQQPKLQTHIVPASNLNKQHADHYLANERKDNALDYKPPV 1063
                    |...:....:|...||...|..:|:.:       ....|.......||:..|...|.
Zfish   967 --------TLEGVQTCCHGDHHSSGSSQTSVQSQV-------HGRGDGSSGGSTKDHGEDASSPT 1016

  Fly  1064 PPHRNV 1069
            ...:.|
Zfish  1017 SKRKRV 1022

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dtn	NP_001284933.1	TMEM132D_N	18..170	CDD:292333	40/152 (26%)
		TMEM132	440..795	CDD:292688	116/368 (32%)
		Big_2	623..676	CDD:295441	18/54 (33%)
		TMEM132D_C	881..984	CDD:292334	30/109 (28%)
tmem132e	NP_001289163.1	TMEM132D_N	56..187	CDD:292333	42/160 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	246..270		5/23 (22%)
		TMEM132	446..790	CDD:292688	116/368 (32%)
		TMEM132D_C	<883..948	CDD:292334	29/95 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	952..1024		15/90 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170576182
Domainoid	1	1.000	191	1.000	Domainoid score	I3176
eggNOG	1	0.900	-	-		E1_KOG4789
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41524
Inparanoid	1	1.050	295	1.000	Inparanoid score	I2730
OMA	1	1.010	-	-		QHG47765
OrthoDB	1	1.010	-	-		D270620at33208
OrthoFinder	1	1.000	-	-		FOG0000636
OrthoInspector	1	1.000	-	-		otm24965
orthoMCL	1	0.900	-	-		OOG6_103670
Panther	1	1.100	-	-	O	PTHR13388
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X430
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.770