Protein Alignment dtn and si:dkey-215k6.1

DIOPT Version :9

• Sequence 1: NP_001284933.1
• Gene: dtn / 31555
• FlyBaseID: FBgn0262730
• Length: 1407
• Species: Drosophila melanogaster
• Sequence 2: XP_684556.5
• Gene: si:dkey-215k6.1 / 556622
• ZFINID: ZDB-GENE-060526-251
• Length: 1105
• Species: Danio rerio
• Alignment Length: 1179
• Identity: 298/1179 - (25%)
• Similarity: 487/1179 - (41%)
• Gaps: 241/1179 - (20%)

  Fly    18 VEVHFEAPDSGFFLKHARQPPVTPEI---ANVQTSSAVPPLRQRSSYDSVLSLDRFTVVETTQP- 78
            |....:..:|.|||:.|     |.|:   .::||.|  .||              |..:....|
Zfish    58 VSCQLQGAESSFFLREA-----TQEVMRNGSLQTRS--EPL--------------FLHLPDAGPA 101

  Fly    79 --VSIRASYGPFSTKQTVPARYIVPDTMDSQSGDYMNNATLLELQQPNMHLDISAHLVRSSVSQD 141
              :|:..|||..:.:..||     |:.:........:.:|.|.|     ...:.||||...:..:
Zfish   102 SILSVNCSYGNLTAESPVP-----PELLQGALPRSFHTSTHLTL-----GWKVRAHLVSRRIGVE 156

  Fly   142 APVLRVLFH-AG-----ADPGGHLQRQKVCVLLHVAMGSEQPLKG----RCMPEGEDGVCVAEVV 196
            ...::|||: ||     .||...|   ..|:  || :|...|.:|    .|..||..|:|||::.
Zfish   157 RSQIQVLFYLAGRRWEDMDPPTEL---LPCI--HV-VGIRDPGEGSISTACRLEGNLGICVAQLN 215

  Fly   197 VPLGWWPQLPAPTQDGSGQAPPKVPQRYAQVSYSVFEPPLRNPEQCEPKVQ---------IQPLT 252
            :|..|: ..|.|.:.|....|..|     ::.||:..|.....|....:||         :|.:.
Zfish   216 IPTSWF-NAPPPRRRGQEPTPITV-----ELHYSISPPEALRKECVAGRVQGKTVGQEGDMQRIG 274

  Fly   253 TFAQVPLLAA--RTPYRMLRADDAVTFLLPQHPLYPLSRLHVPVFLHQYPDQRVAAFTVRARVKA 315
            |   |.|.|.  :.|...||.|..|..|.|..|:.....:...|.::  |......||:|.:...
Zfish   275 T---VTLSAGDNKAPRTRLRLDGDVEILAPPSPVKQGQTVGFQVLMN--PAATTEQFTLRVQYGE 334

  Fly   316 GLKIL----GATASTDQWSVSVEKENPKHTTARVTAFRKEAESSLESGGNLTSEVFEVFSWLLEV 376
            |:..:    |..|:   |.:..|.. |..::..:...|| |.|:.|   .|....:|:. |:...
Zfish   335 GINFMVVKPGNLAT---WEIKQEVV-PGSSSLSIFCQRK-ASSANE---KLDGSYYEIM-WVDFE 390

  Fly   377 AEDTNDIVDGGKIVWSVTHVYDTPKDKDSGELVIPDDNKKRLIAKLEINKDDIQAVLPMAKIWEV 441
            .::...:.....:.|.:.:    |....|.|          :|:.:.|::.|||.::|:|:..|:
Zfish   391 IDNFITLRSSQSVRWQIEY----PSTGASAE----------VISTIYISQRDIQGIVPIAEDTEI 441

  Fly   442 MNTAVLTGRQVAQAMKVFIVSQAGKVADVTLQSSCHAEDESVIKVSSSCSSVYVDGSEQRGSSNA 506
            :|||:||||:|:..:||..|.|.|.|.:|....:|.:.||.|:|||..|..|.|:|:|:||..:.
Zfish   442 LNTAILTGRRVSMPVKVVTVEQDGTVREVDDPITCISTDEDVLKVSLGCDEVLVNGNEKRGRVSL 506

  Fly   507 SVIVKYGTYVGVAKFIVWMPEFPLEVYISDFRLSQIKGWKVTDDNHYLHNKQSRRRKKRSYVWGQ 571
            .|...|.......:..||:|..||::.:||..|:|:|||:|.    .:.||:..|..:......:
Zfish   507 QVNFTYLYLTSQLELTVWVPRLPLQIDVSDVELNQVKGWRVP----IITNKRPTRDSEDDEEDER 567

  Fly   572 HGTNYYNNLGADKTICRARYQQSPVEVYAKFLAVDQN-SGRTSYFISRRTGLRVTDLVQPLLRVA 635
            .|..           |..:||.:.|.|...|:|...: .|...:.:.......:||:|...|:|.
Zfish   568 KGKG-----------CALQYQYALVRVLTHFVAEPADPGGEYVHMLGSDWSADITDMVLDFLKVE 621

  Fly   636 DPKIASL-KGRILQGKSMGRTDVQVLSPITGRVIGTKEIRVGSDKVNLSKLIVRVISGLQLTISP 699
            :.:||.| .||||.|:|.|.|::||:.|:...::..:.|.|..|||:::.|.|:::..|.|::.|
Zfish   622 NTRIARLIDGRILAGRSPGNTNIQVIFPLFYSILAERAITVLDDKVSITDLGVQLVGSLSLSLQP 686

  Fly   700 DNTIENGYLAETSVTHKLTAQYQEGLLDIDLEFTDGSKTPLRDIAVEDYFLLVESLDTEVVAFAP 764
            .:.....:...|:....|....||.::...::::||..|||.....:|:.|.:.|||..||:...
Zfish   687 SSINSRSFYITTTAQDLLHTPKQEAIISAWIQYSDGFVTPLDIYDPKDFTLTITSLDETVVSTYH 751

  Fly   765 MLASHHPRVIAVGEGNGNLLRVTLLLSEECRQRRGTLSSSKQNKSNAAPLASALASIEVDFNNVD 829
            ..:...|.|:|.|||.|.||||.:::||.|           |.....:.||..:.|::|.|...|
Zfish   752 DPSQRWPVVVAEGEGQGALLRVEMMISETC-----------QKSKRKSILAMGVGSVQVKFGQND 805

  Fly   830 IVSK---QEAIQNDGTVGRERKNYRQ---TGD---LADIIVGIPLRDSSQLYEPTVQARQHRGSI 885
            :..:   :|....|.:...:|....:   |||   .|:..|.   |:.|.|.:.:..|:....|.
Zfish   806 LEQRSGTREENSLDNSTNEQRHKVLESDKTGDSWKYANTAVE---REESVLKKISTTAKTTLISR 867

  Fly   886 QAVHKGHHGK-GLAGTGT----------------------MTTMELGMYVLLTAFCFAIIVFVIS 927
            ...:|...|: ..||..|                      ::.:|:|||.||..||.||:||:|:
Zfish   868 SGGNKQGGGQNNNAGDYTSFPVQVDLPGGAESDLTQAPRGLSDLEIGMYALLGVFCLAILVFLIN 932

  Fly   928 CVVYASKFRPAMIESGLDPLSAGKSNGSGGSGGFRDVRLKESTTNAHDWVWLGRSTIDRQSIVAE 992
            ||.:|.::|    ...|..|..|..|                  :||||||||    :...::..
Zfish   933 CVSFAFRYR----HKQLPVLEQGNMN------------------HAHDWVWLG----NEADLIDH 971

  Fly   993 TNTHLNPRDSRMRITSNPIVNYDNGRRVSSFDQQPKLQTHIVPASNLNKQHADHYLANERKDNAL 1057
            ...|            .|:.:.:........::..:...:::..|.:.|..:.|...
Zfish   972 HGEH------------GPLAHSEECTTAIDRNEGCEESKYLLNGSGIQKSGSSHGRG-------- 1016

  Fly  1058 DYKPPVPPHRNVGARACLPVQPVLGTGSVKDAAPNKRHSQLYRREHLQNSDSNANSQQ------S 1116
                  .||.:...|:|....|   ||.|               |.|.||.|.|..::      :
Zfish  1017 ------IPHVHSDPRSCSGNDP---TGKV---------------EPLNNSPSAAKRKRVKFTSFA 1057

  Fly  1117 TPQPNQQLP 1125
            |..|::..|
Zfish  1058 TVLPDEGGP 1066

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dtn	NP_001284933.1	TMEM132D_N	18..170	CDD:292333	38/163 (23%)
		TMEM132	440..795	CDD:292688	115/356 (32%)
		Big_2	623..676	CDD:295441	20/53 (38%)
		TMEM132D_C	881..984	CDD:292334	35/125 (28%)
si:dkey-215k6.1	XP_684556.5	TMEM132D_N	58..194	CDD:292333	42/172 (24%)
		TMEM132	440..782	CDD:292688	116/367 (32%)
		TMEM132D_C	885..967	CDD:292334	30/107 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	191	1.000	Domainoid score	I3176
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	295	1.000	Inparanoid score	I2730
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D270620at33208
OrthoFinder	1	1.000	-	-		FOG0000636
OrthoInspector	1	1.000	-	-		otm24965
orthoMCL	1	0.900	-	-		OOG6_103670
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4244
SonicParanoid	1	1.000	-	-		X430
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.900