DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dtn and Tmem132a

DIOPT Version :9

Sequence 1:	NP_001284933.1	Gene:	dtn / 31555	FlyBaseID:	FBgn0262730	Length:	1407	Species:	Drosophila melanogaster
Sequence 2:	XP_006231103.1	Gene:	Tmem132a / 338474	RGDID:	727936	Length:	1022	Species:	Rattus norvegicus

Alignment Length:	1053	Identity:	266/1053 - (25%)
Similarity:	426/1053 - (40%)	Gaps:	235/1053 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 CLIIALQLSLAYSVEVHFEAPDSGFFLKHARQPPVTPEIANVQTSSAVPP----LRQRSSYDSVL 65
            ||::||.|.:. .|..:.:..|. .:|..|.:....||...||.....||    |..||
  Rat    18 CLLVALALEVV-RVGSNQDTLDP-IYLPVALELLDAPEHFRVQQVGHYPPANSSLGSRS------ 74

  Fly    66 SLDRFTVVE---TTQPVSIRASYGPFSTKQTVPARYIVPDTMDSQSGDYMNNATLLELQQPNMHL 127
              :.|.:::   ..||: :||||.||:|:|.||.|...|.                  ::| :..
  Rat    75 --ETFLLMQPWPRAQPL-LRASYPPFATQQVVPPRVTEPH------------------RRP-VPW 117

  Fly   128 DISAHLVRSSVSQDAPVLRVLFH-AGAD--PG-GHLQRQKVCVLLHVA--MGSEQPLKGRCMPEG 186
            |:.|..|.::|:...|..||||| .|.|  || |.|.    |..||..  .|:...   .|..:.
  Rat   118 DVRAVSVEAAVTPAEPYARVLFHLKGQDWPPGPGSLP----CARLHATHPAGTAHQ---ACRFQP 175

  Fly   187 EDGVCVAEVVVPLGWWPQLPAPTQDGSGQAPPKVPQRYAQVSYSVFEPPLRNPEQC------EPK 245
            ..|.||.|:..|..|:.| .|.|:              |:::|:: ||....|..|      |||
  Rat   176 SLGACVVELEFPSQWFSQ-SATTR--------------AELAYTL-EPAGEGPGGCGPGTEEEPK 224

  Fly   246 VQIQPLTTFAQVPLLAARTP-YRMLRADDAVTFLLPQHPLYPLSRLHVPVFL--HQYPDQRVAAF 307
            .|..|:   ..|.|.....| |:.:..|:.||...|..|:.| .:|.....|  |.:   ..:..
  Rat   225 EQALPV---GSVELHPEDPPQYQEVPLDEVVTLRAPDVPVRP-GQLFTATLLLRHNF---TASLL 282

  Fly   308 TVRARVKAGLKILGA-TASTDQWSVSVEK-ENPKHTTARVTAFR-----KEAESSLESGGNLTSE 365
            |:|.:||.||::..| .|....|:..::: :..||.|:.:|..|     .::.|.||     .||
  Rat   283 TLRIKVKKGLQVTAARPAQPTFWTAKLDRFKGSKHHTSLITCHRTGPAGPDSSSPLE-----LSE 342

  Fly   366 VFEVFSWLLEVAEDTNDIVDGGKIVWSVTHVYDTPKDKDSGELVIPDDNKKRLIAKLEINKDDIQ 430
                |.|:....|  |....|..:...||...:.|     |:  .|:..|.:::.::.:::.||:
  Rat   343 ----FLWVDFAVE--NSTGGGVAVTRPVTWQLEYP-----GQ--APEAEKDKMVWEILVSERDIR 394

  Fly   431 AVLPMAKIWEVMNTAVLTGRQVAQAMKVFIVSQAGKVADVTLQSSCHAEDESVIKVSSSCSSVYV 495
            |::|:||..|::|||.|||......:::..|...|.:.:||....|.:.:..|::||.:|.:|:|
  Rat   395 ALIPLAKAEELVNTAPLTGVPQRIPVRLVTVDSGGALEEVTEHIGCESANTQVLQVSEACDAVFV 459

  Fly   496 DGSEQRGSSNASVIVKYGTYVGVAKFIVWMPEFPLEVYISDFRLSQIKGWKVTD--DNHYLHNKQ 558
            .|.|.||:....|...:.......|..||.|..||.:.::|..|.||:||:|..  :........
  Rat   460 AGQESRGAKGVRVDFWWRRLRASLKLTVWAPLLPLRIELTDTTLEQIRGWRVPGPAEGQLEPEAA 524

  Fly   559 SRRRKKRSYVWGQHGTNYYNNLGADKTICRARYQQSPVEVYAKFLAVDQNSG-RTSYFISRRTGL 622
            :...::||     .|             ||.:||::.|.....|.|...:.| |.::.:.....|
  Rat   525 AEEVERRS-----RG-------------CRLQYQRAGVRFLVPFAAHPLDGGRRLTHLLGPDWLL 571

  Fly   623 RVTDLVQPLLRVADPKIASLK-GRILQGKSMGRTDVQVLSPITGRVIGTKEIRVGSDKVNLSKLI 686
            .|:.||.....|.||:||:|: ||||.|:..|.|.::|.||::..::|.:.:.|..|||::..|.
  Rat   572 DVSHLVAAHAHVQDPRIATLEGGRILVGREPGVTSIEVRSPLSDSILGEQALAVTDDKVSVLDLR 636

  Fly   687 VRVISGLQLTISPDNTIENGYLAETSVTHKLTAQYQEGLLDIDLEFTDGSKTPLRDIAVEDYFLL 751
            |:.:.|:.|::|...:......|.......|.|..||..|.:.|.|:|.:..|.......|..|.
  Rat   637 VQPVMGISLSLSRGVSHPGEVTATCWAQSALPAPKQEVALSLWLSFSDHTLAPAELYDRNDLGLS 701

  Fly   752 VESLDTEVVAFAPMLASHHPRVIAVGEGNGNLLRVTLLLSEECRQRRGTLSSSKQNKSNAAPLAS 816
            |.:.:...|..|....:....|::.....|..|.|.|...|.||:.|           :..||||
  Rat   702 VSAEEPSAVVPAEEQRAQLGVVVSGVGAEGLPLHVALHPPEPCRRGR-----------HRVPLAS 755

  Fly   817 ALASIEV------------------DFNNVDIVSKQEAIQNDGT----------------VGRER 847
            ..|.:.:                  .|....:..|::...:.|:                .|:|.
  Rat   756 GTAWLGLPPLPTPAPALPSSPARTPPFTEASVEGKRQVAGDMGSHVGPGIRGKFERAEEEAGKEE 820

  Fly   848 KNYRQTGDLADIIVGIPLRDSSQLYEPTVQARQHRGSIQAVHKGHHGKGLAGTGTMTTMELGMYV 912
            ...::..:..:.:|..|.|                                    :|.:|||||.
  Rat   821 NEAKEEEEDEEEMVPAPQR------------------------------------VTDLELGMYA 849

  Fly   913 LLTAFCFAIIVFVISCVVYASKF-RPAMIESGLDPLSAGKSNGSGGSGGFRDVRLKESTTNAHDW 976
            ||..||.|.::|:::.||:..:: |....:|..||.|                      ...|:|
  Rat   850 LLGIFCLAFLIFLVNGVVFVLRYQRKEPPDSATDPAS----------------------PQPHNW 892

  Fly   977 VWLG--RSTIDRQ 987
            ||||  :..:.||
  Rat   893 VWLGTNQEELSRQ 905

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dtn	NP_001284933.1	TMEM132D_N	18..170	CDD:292333	47/162 (29%)
		TMEM132	440..795	CDD:292688	99/358 (28%)
		Big_2	623..676	CDD:295441	20/53 (38%)
		TMEM132D_C	881..984	CDD:292334	25/105 (24%)
Tmem132a	XP_006231103.1	TMEM132D_N	44..167	CDD:292333	46/154 (30%)
		TMEM132	404..745	CDD:292688	99/358 (28%)
		TMEM132D_C	<833..900	CDD:292334	28/124 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166337046
Domainoid	1	1.000	197	1.000	Domainoid score	I3005
eggNOG	1	0.900	-	-		E1_KOG4789
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	295	1.000	Inparanoid score	I2661
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D270620at33208
OrthoFinder	1	1.000	-	-		FOG0000636
OrthoInspector	1	1.000	-	-		otm46268
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13388
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X430
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.860