DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dtn and Tmem132e

DIOPT Version :9

Sequence 1:	NP_001284933.1	Gene:	dtn / 31555	FlyBaseID:	FBgn0262730	Length:	1407	Species:	Drosophila melanogaster
Sequence 2:	XP_008766187.1	Gene:	Tmem132e / 287564	RGDID:	1565522	Length:	1073	Species:	Rattus norvegicus

Alignment Length:	1044	Identity:	290/1044 - (27%)
Similarity:	433/1044 - (41%)	Gaps:	253/1044 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 FFLKHARQPPVTPEIANVQTSSAVPPLRQRSSYDSVLSLDRFTVVETTQPVSIRASYGPFSTKQT 93
            ||||.||.|          |.:|:....|||        :.|.|.:|.:...:..|.|||||.|.
  Rat    56 FFLKEARPP----------TPTAMNGSLQRS--------EPFVVFQTKELPVLNVSLGPFSTSQV 102

  Fly    94 VPARYIVPDTMDSQSGDYMNNATLLELQQPNMHLDI----------SAHLVRSSVSQDAPVLRVL 148
            | ||                     ||.||:..|||          .|.:||:.|....||.:||
  Rat   103 V-AR---------------------ELLQPSSTLDIPERLTVNWKVRAFIVRARVPASQPVAQVL 145

  Fly   149 FHAGA---DPGGHLQRQKVCVLLHVAMGSEQPLKGRCMPEGEDGVCVAEVVVPLGWW-PQLPAPT 209
            |:...   |..|..:|.. ||.|| |....:.::..|...|....|:....:||.|: |..||..
  Rat   146 FYVAGRDWDDFGVTERLP-CVRLH-AFRDAREVRSSCRLGGALATCLVRAELPLAWFGPPAPAAP 208

  Fly   210 QDGSGQAP----PKVPQRYAQVS--YSVFEPP-------------------LRNPEQCEPKVQIQ 249
            .....::|    |:......||.  |::..|.                   ..:|.| .|.::|.
  Rat   209 PSTRRKSPDGLEPEATAESQQVELYYTLHAPDAAGGCGSARRGSGPGPAARAESPTQ-HPLLRIG 272

  Fly   250 PLTTFAQVPLLAARTPYRMLRADDAVTFLLPQHPLYPLSRLHVPVFLHQYPDQRVAA------FT 308
            .::.|...|    |...:..|.|..:...||..||.|...|.:.::|  .|:...||      ||
  Rat   273 SISLFRPPP----RRAMQEHRLDSNLMIRLPDRPLRPGEVLSILLYL--APNSSSAASPSLEHFT 331

  Fly   309 VRARVKAGLKILGATASTDQWSVSVE-KENPKHTTARVTAFRKEAE--SSLESGGNLTSEVFEVF 370
            :|.:.|.|:.:||..:...||.|:.| ....||:||.|.....:..  ...||.|.|     |:.
  Rat   332 LRVKAKKGVTLLGTKSRNGQWHVTSELLTGAKHSTATVDVAWAQGTPLPPWESQGPL-----EIL 391

  Fly   371 SWLLEVAEDTNDIVDGGKIVWSVTHVYDTPKDKDSGELVIPDDNKKRLIAKLEINKDDIQAVLPM 435
            ....|:...|:..|. .:|:|.:.:         .|...:||  .:|.:.:|.:.:.|:||:||:
  Rat   392 QLDFEMENFTSQSVK-RRIMWHIDY---------RGHSALPD--LERAVTELTVIQRDVQAILPL 444

  Fly   436 AKIWEVMNTAVLTGRQVAQAMKVFIVSQAGKVADVTLQSSCHAEDESVIKVSSSCSSVYVDGSEQ 500
            |...|::|||:||||.||..:||..:...|.|.||:....|.:..|.:|||||||..|:|.|.|.
  Rat   445 AMDTEIINTAILTGRTVAIPVKVIAIEVTGVVLDVSDLVECQSHREDIIKVSSSCDYVFVSGKES 509

  Fly   501 RGSSNASVIVKYGTYVGVAKFIVWMPEFPLEVYISDFRLSQIKGWKV-----------TDDNHYL 554
            |||.||.|..:|.......:..||:|:.||.:.:||.||||:|||:|           ::|.
  Rat   510 RGSMNARVTFRYDVLSAPLEMTVWVPKLPLHIELSDARLSQVKGWRVPILPDRRSARESEDE--- 571

  Fly   555 HNKQSRRRKKRSYVWGQHGTNYYNNLGADKTICRARYQQSPVEVYAKFLAVDQNSGRTSYFISRR 619
            ..::..||:..             |.|     |..:||.:.::|:.:|   ...|...:..:...
  Rat   572 EEEEEERRQSA-------------NRG-----CTLQYQHATLQVFTQF---HTTSSEGTEQVVTM 615

  Fly   620 TG----LRVTDLVQPLLRVADPKIASL-KGRILQGKSMGRTDVQVLSPITGRVIGTKEIRVGSDK 679
            .|    :.|||||...:||.||::|.| ....|.|...|.|..:|:||:|..|:|...:.|..:|
  Rat   616 LGPDWLVEVTDLVSDFMRVGDPRVAHLVDSNTLAGLEPGTTPFKVVSPLTEAVLGETLLTVTEEK 680

  Fly   680 VNLSKLIVRVISGLQLTISPDNTIENGYLAETSVTHKLTAQYQEGLLDIDLEFTDGSKTPLRDIA 744
            |::::|..:|::.|.|::.|.....:..||.|:....|::..||.||.:.|.::||:..||...:
  Rat   681 VSITQLQAQVVASLTLSLRPSPGSSHTILATTAAQPTLSSVKQEALLSLWLSYSDGTTAPLSLYS 745

  Fly   745 VEDYFLLVESLDTEVVAFAPMLASHHPRVIAVGEGNGNLLRVTLLLSEECRQRRGTLSSSKQNKS 809
            ..||.|||.|||..|.......|  .|.::|..||.|:|||..|.:||.|           |...
  Rat   746 PRDYGLLVNSLDERVATVTQDKA--FPLLVAEAEGAGDLLRAELTISESC-----------QKTK 797

  Fly   810 NAAPLASALASIEVDFNNVDIVSKQEAIQNDGTVGRERKNYRQTGDLADIIVGIPLRDSSQLYEP 874
            ..:.||:....:.|.|                  ||:.::              |..|    |..
  Rat   798 RKSVLATTPVGLRVHF------------------GRDEED--------------PTYD----YPG 826

  Fly   875 TVQARQHRGSIQAVHKGHHGKGL-----AGTGT-----------------------MTTMELGMY 911
            ..|.....|..:|...|..|..:     .|.||                       :|.:|:|||
  Rat   827 PSQPGPGGGEDEARGAGPPGTAIPAGEVPGLGTAGPMPPTEDFLPLPTGFLQMPRGLTDLEIGMY 891

  Fly   912 VLLTAFCFAIIVFVISCVVYASKFRPAMIESGLDPLSAGKSNGSGGSGGFRDVRLKESTTNAHDW 976
            .||..||.||:||:|:|:|:..::|...|.      ..|::                |..::|.|
  Rat   892 ALLGVFCLAILVFLINCIVFVLRYRHKRIP------PEGQT----------------SMDHSHHW 934

  Fly   977 VWLG 980
            |:||
  Rat   935 VFLG 938

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dtn	NP_001284933.1	TMEM132D_N	18..170	CDD:292333	47/153 (31%)
		TMEM132	440..795	CDD:292688	126/370 (34%)
		Big_2	623..676	CDD:295441	21/53 (40%)
		TMEM132D_C	881..984	CDD:292334	32/128 (25%)
Tmem132e	XP_008766187.1	TMEM132D_N	45..176	CDD:292333	49/161 (30%)
		TMEM132	449..794	CDD:292688	127/381 (33%)
		TMEM132D_C	864..941	CDD:292334	25/97 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166337049
Domainoid	1	1.000	197	1.000	Domainoid score	I3005
eggNOG	1	0.900	-	-		E1_KOG4789
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41524
Inparanoid	1	1.050	295	1.000	Inparanoid score	I2661
OMA	1	1.010	-	-		QHG47765
OrthoDB	1	1.010	-	-		D270620at33208
OrthoFinder	1	1.000	-	-		FOG0000636
OrthoInspector	1	1.000	-	-		otm46268
orthoMCL	1	0.900	-	-		OOG6_103670
Panther	1	1.100	-	-	O	PTHR13388
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X430
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770