Protein Alignment dtn and Tmem132d

DIOPT Version :9

• Sequence 1: NP_001284933.1
• Gene: dtn / 31555
• FlyBaseID: FBgn0262730
• Length: 1407
• Species: Drosophila melanogaster
• Sequence 2: NP_766473.1
• Gene: Tmem132d / 243274
• MGIID: 3044963
• Length: 1097
• Species: Mus musculus
• Alignment Length: 1136
• Identity: 287/1136 - (25%)
• Similarity: 472/1136 - (41%)
• Gaps: 262/1136 - (23%)

  Fly    18 VEVHFEAPDSGFFLKHARQPPVTPEIANVQTSSAVPPLRQRSSYDSVLSLDRFTVVETTQPVSIR 82
            |..|....|..||||.|.|                 .:.:.||..|  .::.|.:.::.:...:.
Mouse    49 VTYHINNADVSFFLKEANQ-----------------DIMRNSSLQS--RVESFLIYKSRRLPVLN 94

  Fly    83 ASYGPFSTKQTVPARYIVPDTMDSQSGDYMNNATLLELQQPNMHLDISAHLVRSSVSQDAPVLRV 147
            |||||||.:|.||...::|    |....:.|..:|      |..|  .|::::..|....|.::|
Mouse    95 ASYGPFSLEQVVPQDLMLP----SNPFGFTNTFSL------NWRL--KAYILQEKVYLSHPKVQV 147

  Fly   148 LFH-AGADPGGHLQRQKVCVLLHVAMGSEQPLKGRCMPEGEDGVCVAEVVVPLGWWPQLPAPTQD 211
            ||| .|.|...|......|:.: .|....:.::|.|...|..|:|||::.:..||:    :|...
Mouse   148 LFHIVGRDWDDHRDENLPCLRV-FAFRETREVRGSCRLGGALGLCVAQLEMLPGWF----SPPSV 207

  Fly   212 GSGQAPPKVPQRYAQVSYSVFEPPLRNPEQCEPKVQ----------------------------- 247
            .||:..|.             |.|..||.:....||
Mouse   208 VSGRRRPT-------------EQPEGNPVELYYAVQPGDERGDCAKEDSRKSGGTPAGHNDVDES 259

  Fly   248 IQPLTTFAQVPL--LAARTPYRMLRADDAVTFLLPQHPLYPLSRLHVPVFLHQ-----YP----- 300
            ..||.....|.|  ..:..|.:.||.|..|..    |        :||..:.|     :|
Mouse   260 SPPLHRIGSVFLRETPSSPPLKELRLDSNVAV----H--------YVPKTVRQGDVLTFPISVSR 312

  Fly   301 ---DQRVAAFTVRARVKAGLKILGATASTDQ-WSVSVEKENPKHTTARVTAFRKEAESSLESGGN 361
               :.|   ||:||:||.|:.|:|..||:.. |.|....|........|...:|::..|.:|..:
Mouse   313 NCTEDR---FTLRAKVKKGVSIVGVRASSSSIWDVRQSTEYTGKYAPAVIVCQKKSAGSEKSVAD 374

  Fly   362 LTSEVFEVFSWLLEVAEDTNDIVDGGKIVWSVTHVYDTPKDKDSGELVIPDDNKKRLIAKLEINK 426
            .:.||.::.   :|| |..:|......:.|.|.:..:...|..              ::|:.:::
Mouse   375 ASYEVMKID---IEV-EAPSDPPTTQLVTWQVEYPGEITSDLG--------------VSKIYVSQ 421

  Fly   427 DDIQAVLPMAKIWEVMNTAVLTGRQVAQAMKVFIVSQAGKVADVTLQSSCHAEDESVIKVSSSCS 491
            .|:..|:|:|...|::|||:|||:.||..:||..|.:.|.|..:.....|.:.||.|:|||..|.
Mouse   422 KDLIEVIPLAMEAEILNTAILTGKTVAVPVKVISVEEDGTVQGLLDSVECRSSDEDVVKVSDRCD 486

  Fly   492 SVYVDGSEQRGSSNASVIVKYGTYVGVAKFIVWMPEFPLEVYISDFRLSQIKGWKVTDDNHYLHN 556
            .|:|:|.|.:|..|..|...|.......:..||:|..||::.:||..|:|||||:|.    .:.|
Mouse   487 YVFVNGKEMKGKVNVVVSFTYQHLSSPLEMTVWVPRLPLQIEVSDMELNQIKGWRVP----IVSN 547

  Fly   557 KQSRRRKKRSYVWGQHGTNYYNNLGADKTICRARYQQSPVEVYAKFLA-VDQNSGRTSYFISRRT 620
            |:..|..:......:.|..           |..:||.:.|.|..:|:| .....|..:|.:....
Mouse   548 KRPARDSEEEDDDEKKGRG-----------CTLQYQHAMVRVLTQFVAEAPDPGGHLAYLLGSDW 601

  Fly   621 GLRVTDLVQPLLRVADPKIASLK-GRILQGKSMGRTDVQVLSPITGRVIGTKEIRVGSDKVNLSK 684
            .:.:|:|:...::|.:|:||.|: |:||.|:.:|.|.:|:|||::..::..|.|.|..:||.::.
Mouse   602 QVDITELITDFMQVEEPRIAKLQGGQILTGQELGMTTIQILSPLSDAILAEKTITVLDEKVTITD 666

  Fly   685 LIVRVISGLQLT--ISPDNTIENGYLAETSVTHKLTAQ-YQEGLLDIDLEFTDGSKTPLRDIAVE 746
            |.|::::||.|:  :||.:   |..:..|::..:|..: .||..:...::|:|||.|||.....:
Mouse   667 LGVQLVTGLSLSLQLSPGS---NRAIFATAMAQELLQRPKQEAAISCWVQFSDGSVTPLDIYDEK 728

  Fly   747 DYFLLVESLDTEVVAFAPMLASHHPRVIAVGEGNGNLLRVTLLLSEECRQRRGTLSSSKQNKSNA 811
            |:.|:..|||.:||:.........|.:.|..||.|.|::|.:|:||.|           |.....
Mouse   729 DFSLMATSLDEKVVSILQDPKFKWPIIAAENEGQGALVKVEMLISESC-----------QKSKRK 782

  Fly   812 APLASALASIEVDFNNVDIVSKQEAIQND--------GTVG-----------RERKNYRQTGD-- 855
            :.||...|||:|.|.           |||        |.:|           |.:|.:::.|.
Mouse   783 SVLAVGTASIKVKFG-----------QNDANPNSSESGHLGAGLHVENINDRRSKKPFQEWGSPE 836

  Fly   856 ---LADIIVGIPLRDSSQLYEPTVQARQHRGSI-------------------------QAVHKGH 892
               .:...:|:.....|....||.|.::.:.::                         ..|....
Mouse   837 GPFYSSSSMGLMEGWGSTTKRPTFQKKEGQENLLDDIILSQTMATDLTSFPDQMDLPGSNVGTEE 901

  Fly   893 HGKGLAGTGTMTTMELGMYVLLTAFCFAIIVFVISCVVYASKFRPAMIESGLDPLSAGKSNGSGG 957
            |....|..| ::.:|:|||.||..||.||:||:|:||.:|.|:|...:.
Mouse   902 HDLDQAAKG-LSDLEIGMYALLGVFCLAILVFLINCVTFALKYRHKQVP---------------- 949

  Fly   958 SGGFRDVRLKESTTNAHDWVWLGRST----------IDRQSIVAETNTHLNPRDSRMRITSNPIV 1012
               |.:   :|..:::||||.|...|          ..::..:...:..|:..:|::.::||. .
Mouse   950 ---FEE---QEGLSHSHDWVGLSNRTELLGNHMNFASSQEEQITAIDRGLDFEESKLLLSSNS-Q 1007

  Fly  1013 NYDNGRRVSSF------DQQPKLQTHIVPAS 1037
            |..||:...|.      ||:.|.:....|.|
Mouse  1008 NSINGQMFRSTGAMLTDDQEQKSEPPTSPTS 1038

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dtn	NP_001284933.1	TMEM132D_N	18..170	CDD:292333	40/152 (26%)
		TMEM132	440..795	CDD:292688	115/359 (32%)
		Big_2	623..676	CDD:295441	19/53 (36%)
		TMEM132D_C	881..984	CDD:292334	30/137 (22%)
Tmem132d	NP_766473.1	TMEM132D_N	49..178	CDD:292333	41/160 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	233..263		0/29 (0%)
		TMEM132	435..777	CDD:292688	116/370 (31%)
		TMEM132D_C	884..970	CDD:292334	29/108 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1021..1042		5/18 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167833487
Domainoid	1	1.000	205	1.000	Domainoid score	I2919
eggNOG	1	0.900	-	-		E1_KOG4789
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	298	1.000	Inparanoid score	I2695
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47765
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000636
OrthoInspector	1	1.000	-	-		otm44177
orthoMCL	1	0.900	-	-		OOG6_103670
Panther	1	1.100	-	-	O	PTHR13388
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4244
SonicParanoid	1	1.000	-	-		X430
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.790