DRSC/TRiP Functional Genomics Resources

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Protein Alignment dtn and TMEM132E

DIOPT Version :9

Sequence 1:NP_001284933.1 Gene:dtn / 31555 FlyBaseID:FBgn0262730 Length:1407 Species:Drosophila melanogaster
Sequence 2:NP_001291367.1 Gene:TMEM132E / 124842 HGNCID:26991 Length:1074 Species:Homo sapiens


Alignment Length:1105 Identity:303/1105 - (27%)
Similarity:458/1105 - (41%) Gaps:277/1105 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    29 FFLKHARQPPVTPEIANVQTSSAVPPLRQRSSYDSVLSLDRFTVVETTQPVSIRASYGPFSTKQT 93
            |||:.||.|  :|.:||   ||.     |||        :.|.|.:|.:...:..|.|||||.|.
Human    56 FFLREARPP--SPAVAN---SSL-----QRS--------EPFVVFQTKELPVLNVSLGPFSTSQV 102

  Fly    94 VPARYIVPDTMDSQSGDYMNNATLLELQQPNMHLDI----------SAHLVRSSVSQDAPVLRVL 148
            | ||                     ||.||:..|||          .|.:|||.|....||::||
Human   103 V-AR---------------------ELLQPSSTLDIPERLTVNWKVRAFIVRSHVPASQPVVQVL 145

  Fly   149 FHAGA---DPGGHLQRQKVCVLLHVAMGSEQPLKGRCMPEGEDGVCVAEVVVPLGWWPQLPAPTQ 210
            |:...   |..|..:|.. ||.|| |....:.:|..|...|....|:....:||.|:.. |||. 
Human   146 FYVAGRDWDDFGVTERLP-CVRLH-AFRDAREVKSSCRLSGGLATCLVRAELPLAWFGP-PAPA- 206

  Fly   211 DGSGQAPP----KVP----------QRYAQVSYSVFEPP-------------------LRNPEQC 242
                 |||    |.|          .:.|::.|::..|.                   ..:|.| 
Human   207 -----APPTARRKSPDGLEPEATGESQQAELYYTLHAPDASGGCGGSRRGAGPGVGARAESPTQ- 265

  Fly   243 EPKVQIQPLTTFAQVPLLAARTPYRMLRADDAVTFLLPQHPLYPLSRLHVPVFL---HQYPDQ-R 303
            .|.::|..::.|...|    |...:..|.|..:...||..||.|...|.:.::|   ...|.. .
Human   266 HPLLRIGSISLFRPPP----RRTLQEHRLDSNLMIRLPDRPLKPGEVLSILLYLAPNSSSPSSPS 326

  Fly   304 VAAFTVRARVKAGLKILGATASTDQWSVSVE-KENPKHTTARVTAFRKEAESS----LESGGNLT 363
            |..||:|.:.|.|:.:||..:.:.||.|:.| ....||:||.|..  ..|:|:    .|..|.| 
Human   327 VEHFTLRVKAKKGVTLLGTKSRSGQWHVTSELLTGAKHSTATVDV--AWAQSTPLPPREGQGPL- 388

  Fly   364 SEVFEVFSWLLEVAEDTNDIVDGGKIVWSVTHVYDTPKDKDSGELVIPDDNKKRLIAKLEINKDD 428
                |:.....|:...|:..|. .:|:|.:.:         .|...:||  .:|.:.:|.:.:.|
Human   389 ----EILQLDFEMENFTSQSVK-RRIMWHIDY---------RGHGALPD--LERAVTELTVIQRD 437

  Fly   429 IQAVLPMAKIWEVMNTAVLTGRQVAQAMKVFIVSQAGKVADVTLQSSCHAEDESVIKVSSSCSSV 493
            :||:||:|...|::|||:||||.||..:||..:...|.|.|::....|.:::|.:|||||||..|
Human   438 VQAILPLAMDTEIINTAILTGRTVAIPVKVIAIEVNGLVLDISALVECESDNEDIIKVSSSCDYV 502

  Fly   494 YVDGSEQRGSSNASVIVKYGTYVGVAKFIVWMPEFPLEVYISDFRLSQIKGWKV----------- 547
            :|.|.|.|||.||.|..:|.......:..||:|:.||.:.:||.||||:|||:|           
Human   503 FVSGKESRGSMNARVTFRYDVLNAPLEMTVWVPKLPLHIELSDARLSQVKGWRVPILPDRRSVRE 567

  Fly   548 TDDNHYLHNKQSRRRKKRSYVWGQHGTNYYNNLGADKTICRARYQQSPVEVYAKF-LAVDQNSGR 611
            ::|.   ..::..||:..|     .|             |..:||.:.::|:.:| ....:.:.:
Human   568 SEDE---DEEEEERRQSAS-----RG-------------CTLQYQHATLQVFTQFHTTSSEGTDQ 611

  Fly   612 TSYFISRRTGLRVTDLVQPLLRVADPKIASL-KGRILQGKSMGRTDVQVLSPITGRVIGTKEIRV 675
            ....:.....:.|||||...:||.||::|.: ....|.|...|.|..:|:||:|..|:|...:.|
Human   612 VVTMLGPDWLVEVTDLVSDFMRVGDPRVAHMVDSSTLAGLEPGTTPFKVVSPLTEAVLGETLLTV 676

  Fly   676 GSDKVNLSKLIVRVISGLQLTISPDNTIENGYLAETSVTHKLTAQYQEGLLDIDLEFTDGSKTPL 740
            ..:||::::|..:|::.|.|::.|.....:..||.|:....|:...||.||.:.|.::||:..||
Human   677 TEEKVSITQLQAQVVASLALSLRPSPGSSHTILATTAAQQTLSFLKQEALLSLWLSYSDGTTAPL 741

  Fly   741 RDIAVEDYFLLVESLDTEVVAFAPMLASHHPRVIAVGEGNGNLLRVTLLLSEECRQRRGTLSSSK 805
            ...:..||.|||.|||..|.......|  .|.|:|..||:|.|||..|.::|.|           
Human   742 SLYSPRDYGLLVSSLDEHVATVTQDRA--FPLVVAEAEGSGELLRAELTIAESC----------- 793

  Fly   806 QNKSNAAPLASALASIEVDFNNVDIVSKQEAIQNDGTVGRERKNYRQTGDLADIIVGIPLRDSSQ 870
            |.....:.||:....:.|.|                  ||:.::              |..|   
Human   794 QKTKRKSVLATTPVGLRVHF------------------GRDEED--------------PTYD--- 823

  Fly   871 LYEPTVQARQHRGSIQAVHKGHHGKGL-----AGTGT------------------------MTTM 906
             |....|.....|..:|...|..|..|     .|.||                        :|.:
Human   824 -YPGPSQPGPGGGEDEARGAGPPGSALPAPEAPGPGTASPVVPPTEDFLPLPTGFLQVPRGLTDL 887

  Fly   907 ELGMYVLLTAFCFAIIVFVISCVVYASKFRPAMIESGLDPLSAGKSNGSGGSGGFRDVRLKESTT 971
            |:|||.||..||.||:||:|:|:|:..::|...|.      ..|::                |..
Human   888 EIGMYALLGVFCLAILVFLINCIVFVLRYRHKRIP------PEGQT----------------SMD 930

  Fly   972 NAHDWVWLGRSTIDRQSIVAETNTHLNPRDSRMRITSNPIVN---YDNGRRVSSFDQQPKLQTHI 1033
            ::|.||:||.....|      ....|:|.      ..||:..   :.:|...||...|..:|:.:
Human   931 HSHHWVFLGNGQPLR------VQGELSPP------AGNPLETVPAFCHGDHHSSGSSQTSVQSQV 983

  Fly  1034  1033
            Human   984  983

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dtnNP_001284933.1 TMEM132D_N 18..170 CDD:292333 50/153 (33%)
TMEM132 440..795 CDD:292688 122/367 (33%)
Big_2 623..676 CDD:295441 20/53 (38%)
TMEM132D_C 881..984 CDD:292334 33/131 (25%)
TMEM132ENP_001291367.1 TMEM132D_N 45..175 CDD:318006 52/160 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 202..226 8/30 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 241..264 0/22 (0%)
TMEM132 449..794 CDD:339594 123/378 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 563..585 4/29 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 814..867 14/70 (20%)
TMEM132D_C 863..941 CDD:318007 25/99 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 946..1063 9/44 (20%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165143317
Domainoid 1 1.000 205 1.000 Domainoid score I2924
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H41524
Inparanoid 1 1.050 302 1.000 Inparanoid score I2679
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG47765
OrthoDB 1 1.010 - - D270620at33208
OrthoFinder 1 1.000 - - FOG0000636
OrthoInspector 1 1.000 - - otm42121
orthoMCL 1 0.900 - - OOG6_103670
Panther 1 1.100 - - O PTHR13388
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4244
SonicParanoid 1 1.000 - - X430
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
1413.940

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